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1.发明授权Proteins and nucleic acids from meningitis/sepsis-associated Escherichia coli 有权来自脑膜炎/败血症相关大肠杆菌的蛋白质和核酸公开(公告)号：US08758764B2
公开(公告)日：2014-06-24
申请号：US11884812
申请日：2006-02-17
申请人： Vega Masignani , Danilo Gomes Moriel , Francesco Berlanda Scorza , Nathalie Norais , Maria Rita Fontana , Mariagrazia Pizza , Laura Serino , Herve Tettelin
发明人： Vega Masignani , Danilo Gomes Moriel , Francesco Berlanda Scorza , Nathalie Norais , Maria Rita Fontana , Mariagrazia Pizza , Laura Serino , Herve Tettelin
IPC分类号： A61K39/108 , C07K14/245
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K2039/505 , A61K2039/523 , C07K16/1232
摘要： Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunising against MNEC infections.
摘要翻译： 本文公开了来自负责新生儿脑膜炎（MNEC）的大肠杆菌菌株的各种开放阅读框，以及对于制备用于免疫MNEC感染的组合物特别有意义的这些的一部分。
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2.发明申请Proteins and Nucleic Acids from Meningitis/Sepsis-Associated Escherichia Coli 有权来自脑膜炎/脓毒症相关大肠杆菌的蛋白质和核酸公开(公告)号：US20080193470A1
公开(公告)日：2008-08-14
申请号：US11884812
申请日：2006-02-17
申请人： Vega Masignani , Danilo Gomes Moriel , Francesco Bertanda Scorza , Nathalie Norais , Maria Rita Fontana , Mariagrazia Pizza , Laura Serino , Herve Tettelin
发明人： Vega Masignani , Danilo Gomes Moriel , Francesco Bertanda Scorza , Nathalie Norais , Maria Rita Fontana , Mariagrazia Pizza , Laura Serino , Herve Tettelin
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K2039/505 , A61K2039/523 , C07K16/1232
摘要： Disclosed herein are various open reading frames from a strain of E. coli responsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunising against MNEC infections.
摘要翻译： 本文公开了来自负责新生儿脑膜炎（MNEC）的大肠杆菌菌株的各种开放阅读框，以及对于制备用于免疫MNEC感染的组合物特别有意义的这些的一部分。
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公开(公告)号：US20100166788A1
公开(公告)日：2010-07-01
申请号：US12377572
申请日：2007-08-15
申请人： Francesco Berlanda Scorza , Danilo Gomes Moriel , Jörg Hacker , Mariagrazia Pizza , Laura Serino , Maria Rita Fontana
发明人： Francesco Berlanda Scorza , Danilo Gomes Moriel , Jörg Hacker , Mariagrazia Pizza , Laura Serino , Maria Rita Fontana
CPC分类号： A61K39/0258 , Y02A50/474
摘要： Disclosed herein are various polypeptides that can be included in immunogenic compositions specific for pathogenic E. coli strains. The polypeptides have cellular locations which render them accessible to the immune system. The genes encoding the polypeptides were initially identified as being present in uropathogenic strain 536 but absent from non-pathogenic strains.
摘要翻译： 本文公开了可以包含在对致病性大肠杆菌菌株特异性的免疫原性组合物中的各种多肽。 这些多肽具有让其免疫系统可接近的细胞位置。 编码多肽的基因最初被鉴定为存在于致病菌株536中，但不存在于非致病菌株中。
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公开(公告)号：US08062644B2
公开(公告)日：2011-11-22
申请号：US11884825
申请日：2006-02-17
申请人： Mariagrazia Pizza , Laura Serino , Francesco Berlanda Scorza , Danilo Gomes Moriel , Maria Rita Fontana
发明人： Mariagrazia Pizza , Laura Serino , Francesco Berlanda Scorza , Danilo Gomes Moriel , Maria Rita Fontana
IPC分类号： A61K39/108 , A61K39/00 , A61K39/02
CPC分类号： C07K14/245 , A61K38/00 , Y02A50/473
摘要： Disclosed herein are various genes that can be included in immunogenic compositions specific for pathogenic E. coli strains. The genes are from uropathogenic strains but are absent from non-pathogenic strains, and their encoded proteins have cellular locations which render them accessible to the immune system.
摘要翻译： 本文公开了可以包含在对病原性大肠杆菌菌株特异性的免疫原性组合物中的各种基因。 这些基因来自尿毒性致病菌株，但不存在于非致病菌株中，并且它们编码的蛋白质具有使其免疫系统可接近的细胞位置。
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公开(公告)号：US20130004531A1
公开(公告)日：2013-01-03
申请号：US13603391
申请日：2012-09-04
申请人： Francesco BERLANDA SCORZA , Maria Rita Fontana , Danilo Gomes Moriel , Mariagrazia Pizza , Laura Serino , Jörg Hacker
发明人： Francesco BERLANDA SCORZA , Maria Rita Fontana , Danilo Gomes Moriel , Mariagrazia Pizza , Laura Serino , Jörg Hacker
IPC分类号： C07K14/245 , C07K7/06 , A61P31/04 , A61K39/108 , A61P37/04
CPC分类号： A61K39/0258 , Y02A50/474
摘要： Disclosed herein are various polypeptides that can be included in immunogenic compositions specific for pathogenic E. coli strains. The polypeptides have cellular locations which render them accessible to the immune system. The genes encoding the polypeptides were initially identified as being present in uropathogenic strain 536 but absent from non-pathogenic strains.
摘要翻译： 本文公开了可以包含在对致病性大肠杆菌菌株特异性的免疫原性组合物中的各种多肽。 这些多肽具有让其免疫系统可接近的细胞位置。 编码多肽的基因最初被鉴定为存在于致病菌株536中，但不存在于非致病菌株中。
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公开(公告)号：US08470341B2
公开(公告)日：2013-06-25
申请号：US12735848
申请日：2009-02-23
IPC分类号： A61K39/108 , C07K14/00 , C12N1/20
CPC分类号： A61K39/0258 , C07K14/245
摘要： Variants of the pathogenic E. coli ‘AcfD precursor’ have been identified with increased solubility as compared to the native AcfD protein that raise a substantially similar immune response in a subject as the native AcfD protein.
摘要翻译： 与天然AcfD蛋白质相比，与天然AcfD蛋白质在主体中产生基本上相似的免疫应答的天然AcfD蛋白质相比，鉴定出致病性大肠杆菌“AcfD前体”的变体具有增加的溶解度。
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公开(公告)号：US20110091492A1
公开(公告)日：2011-04-21
申请号：US12735848
申请日：2009-02-23
CPC分类号： A61K39/0258 , C07K14/245
摘要： Variants of the pathogenic E. coli ‘AcfD precursor’ have been identified with increased solubility as compared to the native AcfD protein that raise a substantially similar immune response in a subject as the native AcfD protein.
摘要翻译： 与天然AcfD蛋白质相比，与天然AcfD蛋白质在主体中产生基本上相似的免疫应答的天然AcfD蛋白质相比，鉴定出致病性大肠杆菌“AcfD前体”的变体具有增加的溶解度。
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公开(公告)号：US20090298099A1
公开(公告)日：2009-12-03
申请号：US12371691
申请日：2009-02-16
IPC分类号： G01N33/571 , C07K14/00 , C07K16/18 , C12N15/11
摘要： The invention provides proteins from gonococcus (Neisseria gonorrhoeae), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. They are also useful for distinguishing between gonococcus and meningococcus and, in particular, between gonococcus and serogroup B meningococcus.
摘要翻译： 本发明提供来自淋球菌（Neisseria gonorrhoeae）的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。 它们也可用于区分淋球菌和脑膜炎球菌，特别是在淋球菌和血清群B脑膜炎球菌之间。
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公开(公告)号：US08642050B2
公开(公告)日：2014-02-04
申请号：US12371691
申请日：2009-02-16
IPC分类号： A61K39/095 , C07K14/22 , C12P21/06
摘要： The invention provides proteins from gonococcus (Neisseria gonorrhoeae), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. They are also useful for distinguishing between gonococcus and meningococcus and, in particular, between gonococcus and serogroup B meningococcus.
摘要翻译： 本发明提供来自淋球菌（Neisseria gonorrhoeae）的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。 它们也可用于区分淋球菌和脑膜炎球菌，特别是在淋球菌和血清群B脑膜炎球菌之间。
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公开(公告)号：US20080166370A1
公开(公告)日：2008-07-10
申请号：US10561235
申请日：2004-06-25
CPC分类号： C07K14/22 , A61K39/095
摘要： N. gonorrhoeae is a bacterial pathogen which causes diseases including gonorrhoea, urethritis, cervicitis and pelvic inflammatory disease. In addition, like other inflammatory SYDs, infection is believed to enhance HIV transmission. Within the many proteins of the gonococcal *enome, six have been found to be particularly suitable for immunisation purposes, particularly', when used in combinations. The invention therefore provides a composition comprising two or more of the following antigens: (1) OmpA; (2) OmpH; (3) PPIase; (4) ngs41; (5) ngsl 17; and (6)', App.
摘要翻译： 淋病奈瑟氏球菌是引起淋病，尿道炎，子宫颈炎和盆腔炎等疾病的细菌性病原体。 此外，像其他炎症性SYD一样，感染被认为是增强HIV的传播。 在淋球菌*的许多蛋白质内，已经发现6种特别适用于免疫目的，特别是当组合使用时。 因此，本发明提供包含两种或更多种以下抗原的组合物：（1）OmpA; （2）OmpH; （3）PPIase; （4）ngs 41; （5）ngsl 17; 和（6）'，App。
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