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公开(公告)号：US20050075383A1
公开(公告)日：2005-04-07
申请号：US10930569
申请日：2004-08-30
申请人： Venkata Palle , Sarala Balachandran , Mohammad Salman , Gagan Kukreja , Nidhi Gupta , Abhijit Ray , Sunanda Dastidar
发明人： Venkata Palle , Sarala Balachandran , Mohammad Salman , Gagan Kukreja , Nidhi Gupta , Abhijit Ray , Sunanda Dastidar
IPC分类号： A61K31/42 , A61K31/422 , A61K31/423 , A61K31/424 , C07C45/61 , C07C269/06 , C07D261/02 , C07D261/04 , C07D261/20 , C07D413/06 , C07D413/14 , C07D487/08 , C07D491/02 , C07D498/10
CPC分类号： C07D261/04 , C07D498/10
摘要： The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
摘要翻译： 本发明涉及异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 特别地，本文公开的化合物可用于治疗AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是在人类中。 本发明还涉及制备所公开的化合物及其药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途的方法。
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公开(公告)号：US20070259874A1
公开(公告)日：2007-11-08
申请号：US10596059
申请日：2004-11-26
申请人： Venkata Palle , Sarala Balachandran , Nidhi Gupta , Gagan Kukreja , Manoj Khera , Lalit Baregama , Raghuramaiah Mandadapu , Abhijit Ray , Sunanda Dastidar
发明人： Venkata Palle , Sarala Balachandran , Nidhi Gupta , Gagan Kukreja , Manoj Khera , Lalit Baregama , Raghuramaiah Mandadapu , Abhijit Ray , Sunanda Dastidar
IPC分类号： A61K31/42 , A61K31/4245 , A61K31/433 , A61K31/5375 , A61P1/04 , A61P11/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , A61P9/00 , C07D261/00 , C07D271/06 , C07D271/10 , C07D271/113 , C07D285/135 , C07D413/00
CPC分类号： C07D413/04 , C07D261/04 , C07D413/12 , C07D413/14 , C07D417/04
摘要： The present invention relates to isoxazoline derivatives and their analogues, which can be used as phosphodiesterase (PDE) type IV selective inhibitors. Compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases, especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and their use as PDE type IV selective inhibitors, are provided.
摘要翻译： 本发明涉及可用作磷酸二酯酶（PDE）IV型选择性抑制剂的异恶唑啉衍生物及其类似物。 本文公开的化合物可用于治疗AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS），嗜酸粒细胞性肉芽肿， 过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。 提供制备所公开化合物的方法，含有所公开化合物的药物组合物及其作为PDE IV型选择性抑制剂的用途。
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公开(公告)号：US20080312285A1
公开(公告)日：2008-12-18
申请号：US12065819
申请日：2006-08-30
申请人： Venkata Palle , Sarala Balachandran , Lalit Kumar Baregama , Saswati Chakladar , Sarika Ramnani , Nagarajan Muthukamal , Abhijit Ray , Sunanda G. Dastidar
发明人： Venkata Palle , Sarala Balachandran , Lalit Kumar Baregama , Saswati Chakladar , Sarika Ramnani , Nagarajan Muthukamal , Abhijit Ray , Sunanda G. Dastidar
IPC分类号： A61K31/4439 , C07D413/10 , A61K31/422 , A61K31/4245 , A61P11/06 , C07D413/14 , A61P31/18
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula (Ia)
摘要翻译： 本发明涉及结构Ia的异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 本文公开的化合物可用于治疗CNS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。 式（Ia）
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公开(公告)号：US07781460B2
公开(公告)日：2010-08-24
申请号：US12065819
申请日：2006-08-30
申请人： Venkata Palle , Sarala Balachandran , Lalit Kumar Baregama , Saswati Chakladar , Sarika Ramnani , Nagarajan Muthukamal , Abhijit Ray , Sunanda G. Dastidar
发明人： Venkata Palle , Sarala Balachandran , Lalit Kumar Baregama , Saswati Chakladar , Sarika Ramnani , Nagarajan Muthukamal , Abhijit Ray , Sunanda G. Dastidar
IPC分类号： A61K31/443 , A61K31/416 , A61K31/422 , A61K31/427 , C07D413/04 , C07D271/06 , C07D271/10 , C07D261/04
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.
摘要翻译： 本发明涉及结构Ia的异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 本文公开的化合物可用于治疗CNS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。
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公开(公告)号：US20080114031A1
公开(公告)日：2008-05-15
申请号：US11692362
申请日：2007-03-28
申请人： Viswajanani Sattigeri , Sudershan Arora , Mohammad Salman , Venkata Palle , Ashis Mukherji , Ashwani Verna , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Raj Shirumalla
发明人： Viswajanani Sattigeri , Sudershan Arora , Mohammad Salman , Venkata Palle , Ashis Mukherji , Ashwani Verna , Sanjay Malhotra , Sankaranarayanan Dharmarajan , Abhijit Ray , Raj Shirumalla
IPC分类号： A61K31/4525 , A61K31/34 , A61P17/00 , A61P29/00 , A61P3/10 , A61P35/00 , A61P37/00 , A61P9/00 , C07D307/20 , C07D405/02 , C07D405/14 , C07D413/02
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 包含本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植物排斥反应，炎症性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。
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6.发明申请公开(公告)号：US20090054519A1
公开(公告)日：2009-02-26
申请号：US11996407
申请日：2006-07-20
申请人： Abhijit Ray , Raj Kumar Shirumalla , Kasim Mookhtiar , Viswajanani J. Sattigeri , Venkata Palle , Mohammad Salman
发明人： Abhijit Ray , Raj Kumar Shirumalla , Kasim Mookhtiar , Viswajanani J. Sattigeri , Venkata Palle , Mohammad Salman
CPC分类号： A61K31/70
摘要： The present invention relates to the use of derivatives of monosaccharides as 5-lipoxygenase inhibitor.
摘要翻译： 本发明涉及单糖衍生物作为5-脂氧合酶抑制剂的用途。
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公开(公告)号：US20110257127A1
公开(公告)日：2011-10-20
申请号：US13169834
申请日：2011-06-27
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： A61K31/695 , A61P11/06 , A61P35/00 , A61P9/10 , A61P25/00 , A61P25/28 , A61P25/16 , A61P3/10 , A61K31/522 , A61P1/00
CPC分类号： C07D473/06 , A61K31/522 , C07D473/04
摘要： Disclosed are novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
摘要翻译： 公开了作为A2B腺苷受体拮抗剂的新型化合物，其可用于治疗各种疾病状态，包括哮喘和腹泻。
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公开(公告)号：US07795269B2
公开(公告)日：2010-09-14
申请号：US11949229
申请日：2007-12-03
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： A61K31/522 , C07D473/12 , C07D473/06 , C07D473/04 , A61P11/06 , A61P9/10 , A61P3/10
CPC分类号： C07D473/06 , A61K31/522 , C07D473/04
摘要： Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angiogenesis.
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公开(公告)号：US07741331B2
公开(公告)日：2010-06-22
申请号：US11950740
申请日：2007-12-05
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： A61K31/522 , A61P11/06 , A61P1/12 , A61P27/02 , C07D473/12 , C07D473/06 , C07D473/04
CPC分类号： C07D473/06 , A61K31/522 , C07D473/04
摘要： Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angiogenesis.
摘要翻译： 公开了具有式I或式II结构的新型A2B腺苷受体拮抗剂：该化合物特别可用于治疗哮喘，炎症性胃肠道疾病，心血管疾病，神经障碍和与不期望的血管发生相关的疾病。
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公开(公告)号：US07713946B2
公开(公告)日：2010-05-11
申请号：US11641234
申请日：2006-12-18
申请人： Arvinder Dhalla , Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Vaibhav Varkhedkar , Jeff Zablocki
发明人： Arvinder Dhalla , Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Vaibhav Varkhedkar , Jeff Zablocki
CPC分类号： A61K31/52 , A61K31/7076
摘要： Disclosed are novel compounds a compound of Formula I that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular dyslipidemia, diabetes, decreased insulin sensitivity, Polycystic Ovarian Syndrome, Stein-Leventhal syndrome, and obesity.
摘要翻译： 公开了作为部分和全部A1腺苷受体激动剂的新颖化合物，其可用于治疗各种疾病状态，特别是血脂异常，糖尿病，胰岛素敏感性降低，多囊卵巢综合征，Stein-Leventhal综合征和肥胖症。
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