公开(公告)号：US20090054519A1

公开(公告)日：2009-02-26

申请号：US11996407

申请日：2006-07-20

申请人： Abhijit Ray ,  Raj Kumar Shirumalla ,  Kasim Mookhtiar ,  Viswajanani J. Sattigeri ,  Venkata Palle ,  Mohammad Salman

发明人： Abhijit Ray ,  Raj Kumar Shirumalla ,  Kasim Mookhtiar ,  Viswajanani J. Sattigeri ,  Venkata Palle ,  Mohammad Salman

IPC分类号： A61K31/36 ,  A61P43/00

CPC分类号： A61K31/70

摘要： The present invention relates to the use of derivatives of monosaccharides as 5-lipoxygenase inhibitor.

摘要翻译： 本发明涉及单糖衍生物作为5-脂氧合酶抑制剂的用途。

公开(公告)号：US20090137623A1

公开(公告)日：2009-05-28

申请号：US12158435

申请日：2007-01-02

申请人： Naresh Kumar ,  Ian Anthony Cliffe ,  Mohammad Salman ,  Venkata P. Palle ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

发明人： Naresh Kumar ,  Ian Anthony Cliffe ,  Mohammad Salman ,  Venkata P. Palle ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

IPC分类号： A61K31/439 ,  C07D487/08 ,  A61P1/00 ,  A61P3/10 ,  A61P3/04 ,  A61P11/06

CPC分类号： C07D209/52

摘要： The present invention relates to muscarinic receptor modulators, specifically, 7-oxo-2-azabicyclo[2.2.1]heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, particularly schizophrenia or schizophreniform conditions, mania, pain, bipolar disorder, depression, sleeping disorders, epilepsy, gastrointestinal motility disorders, urinary incontinence, and cognition enhancement.

摘要翻译： 本发明涉及可用于治疗各种疾病和病症（例如阿尔茨海默病，青光眼，精神病）的式（I）的毒蕈碱受体调节剂，具体地，7-氧代-2-氮杂双环[2.2.1]庚烷 特别是精神分裂症或精神分裂症状，躁狂症，疼痛，双相情感障碍，抑郁症，睡眠障碍，癫痫，胃肠动力障碍，尿失禁和认知增强。

公开(公告)号：US20090048186A1

公开(公告)日：2009-02-19

申请号：US11912064

申请日：2005-04-19

申请人： Vishwajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Mohammad Salman ,  Venkata P. Palle ,  Ashis Mukherjee ,  Abhijit Ray ,  Raj Kumar Shirumalla

发明人： Vishwajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Mohammad Salman ,  Venkata P. Palle ,  Ashis Mukherjee ,  Abhijit Ray ,  Raj Kumar Shirumalla

IPC分类号： A61K31/7052 ,  C07H15/18 ,  A61K31/7034 ,  C07D493/04 ,  C07H17/02

CPC分类号： C07H9/04 ,  C07H3/02 ,  C07H15/00

摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

公开(公告)号：US20090221515A1

公开(公告)日：2009-09-03

申请号：US11574465

申请日：2005-08-31

申请人： Viswajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Venkata P. Palle ,  Mohammad Salman ,  Abhijit Ray ,  Raj Kumar Shirumalla ,  Abdul Rehaman Abdul Rauf

发明人： Viswajanani Jitendra Sattigeri ,  Sudershan K. Arora ,  Venkata P. Palle ,  Mohammad Salman ,  Abhijit Ray ,  Raj Kumar Shirumalla ,  Abdul Rehaman Abdul Rauf

IPC分类号： A61K31/7008 ,  C07H5/04

CPC分类号： C07H15/18

摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis. Pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮 ，动脉粥样硬化，癌症，瘙痒症或过敏性鼻炎。 包含本发明化合物的药物组合物，治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症， 还提供了使用该化合物的瘙痒症，过敏性鼻炎和其它炎性和/或自身免疫性疾病。

公开(公告)号：US20050075383A1

公开(公告)日：2005-04-07

申请号：US10930569

申请日：2004-08-30

申请人： Venkata Palle ,  Sarala Balachandran ,  Mohammad Salman ,  Gagan Kukreja ,  Nidhi Gupta ,  Abhijit Ray ,  Sunanda Dastidar

发明人： Venkata Palle ,  Sarala Balachandran ,  Mohammad Salman ,  Gagan Kukreja ,  Nidhi Gupta ,  Abhijit Ray ,  Sunanda Dastidar

IPC分类号： A61K31/42 ,  A61K31/422 ,  A61K31/423 ,  A61K31/424 ,  C07C45/61 ,  C07C269/06 ,  C07D261/02 ,  C07D261/04 ,  C07D261/20 ,  C07D413/06 ,  C07D413/14 ,  C07D487/08 ,  C07D491/02 ,  C07D498/10

CPC分类号： C07D261/04 ,  C07D498/10

摘要： The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.

摘要翻译： 本发明涉及异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 特别地，本文公开的化合物可用于治疗AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是在人类中。 本发明还涉及制备所公开的化合物及其药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途的方法。

公开(公告)号：US20080114031A1

公开(公告)日：2008-05-15

申请号：US11692362

申请日：2007-03-28

申请人： Viswajanani Sattigeri ,  Sudershan Arora ,  Mohammad Salman ,  Venkata Palle ,  Ashis Mukherji ,  Ashwani Verna ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Raj Shirumalla

发明人： Viswajanani Sattigeri ,  Sudershan Arora ,  Mohammad Salman ,  Venkata Palle ,  Ashis Mukherji ,  Ashwani Verna ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Abhijit Ray ,  Raj Shirumalla

IPC分类号： A61K31/4525 ,  A61K31/34 ,  A61P17/00 ,  A61P29/00 ,  A61P3/10 ,  A61P35/00 ,  A61P37/00 ,  A61P9/00 ,  C07D307/20 ,  C07D405/02 ,  C07D405/14 ,  C07D413/02

CPC分类号： C07H9/04 ,  C07H3/02 ,  C07H15/00

摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。 包含本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植物排斥反应，炎症性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

公开(公告)号：US20100168197A1

公开(公告)日：2010-07-01

申请号：US12528987

申请日：2008-02-27

申请人： Naresh Kumar ,  Jaskiran Kaur ,  Shelly Aeron ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Raj Kumar Shirumalla

发明人： Naresh Kumar ,  Jaskiran Kaur ,  Shelly Aeron ,  Abhijit Ray ,  Suman Gupta ,  Shivani Malhotra ,  Raj Kumar Shirumalla

IPC分类号： A61K31/4164 ,  C07D233/54

CPC分类号： C07D235/08 ,  C07D233/54 ,  C07D409/06

摘要： This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20100222393A1

公开(公告)日：2010-09-02

申请号：US12159505

申请日：2006-12-21

申请人： Naresh Kumar ,  Jaskiran Kaur ,  Venkata P. Palle ,  Beenu Bhatt ,  Shelly Jindal ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

发明人： Naresh Kumar ,  Jaskiran Kaur ,  Venkata P. Palle ,  Beenu Bhatt ,  Shelly Jindal ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

IPC分类号： A61K31/4439 ,  C07D233/54 ,  A61K31/4164 ,  C07D401/02 ,  A61P11/00 ,  A61P13/00 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D233/54 ,  C07D233/14 ,  C07D233/56 ,  C07D233/64 ,  C07D401/12

摘要： Compounds of Formula (I), wherein represents a single bond when G is —OH and double bond when G is —O; R1 and R2 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, heterocyclylalkyl or heteroarylalkyl; R3 is selected from the group selected from hydrogen, hydroxy, alkoxy, alkenyloxy or alkynyloxy; X is selected from oxygen, —NH, —NR (wherein R is alkyl, alkenyl, alkenyl, alkynyl or aryl), sulphur or no atom; Het is heterocyclyl or heteroaryl; n is an integer from 1 to 6; are muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and 4 i gastrointestinal systems mediated through muscarinic receptors.

摘要翻译： 式（I）的化合物，当G为-OH时，当G为-O时，表示单键; R 1和R 2独立地选自氢，烷基，烯基，炔基，芳烷基，环烷基，芳基，杂芳基，杂环基，杂环基烷基或杂芳基烷基; R3选自氢，羟基，烷氧基，烯氧基或炔氧基; X选自氧，-NH，-NR（其中R是烷基，烯基，烯基，炔基或芳基），硫或无原子; Het是杂环基或杂芳基; n是1至6的整数; 是毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和4I胃肠系统的各种疾病，以及其它用途。

公开(公告)号：US20080312285A1

公开(公告)日：2008-12-18

申请号：US12065819

申请日：2006-08-30

申请人： Venkata Palle ,  Sarala Balachandran ,  Lalit Kumar Baregama ,  Saswati Chakladar ,  Sarika Ramnani ,  Nagarajan Muthukamal ,  Abhijit Ray ,  Sunanda G. Dastidar

发明人： Venkata Palle ,  Sarala Balachandran ,  Lalit Kumar Baregama ,  Saswati Chakladar ,  Sarika Ramnani ,  Nagarajan Muthukamal ,  Abhijit Ray ,  Sunanda G. Dastidar

IPC分类号： A61K31/4439 ,  C07D413/10 ,  A61K31/422 ,  A61K31/4245 ,  A61P11/06 ,  C07D413/14 ,  A61P31/18

CPC分类号： C07D413/04 ,  C07D413/14

摘要： The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors. Formula (Ia)

摘要翻译： 本发明涉及结构Ia的异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 本文公开的化合物可用于治疗CNS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。 式（Ia）

公开(公告)号：US20070259874A1

公开(公告)日：2007-11-08

申请号：US10596059

申请日：2004-11-26

申请人： Venkata Palle ,  Sarala Balachandran ,  Nidhi Gupta ,  Gagan Kukreja ,  Manoj Khera ,  Lalit Baregama ,  Raghuramaiah Mandadapu ,  Abhijit Ray ,  Sunanda Dastidar

发明人： Venkata Palle ,  Sarala Balachandran ,  Nidhi Gupta ,  Gagan Kukreja ,  Manoj Khera ,  Lalit Baregama ,  Raghuramaiah Mandadapu ,  Abhijit Ray ,  Sunanda Dastidar

IPC分类号： A61K31/42 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/5375 ,  A61P1/04 ,  A61P11/08 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  A61P9/00 ,  C07D261/00 ,  C07D271/06 ,  C07D271/10 ,  C07D271/113 ,  C07D285/135 ,  C07D413/00

CPC分类号： C07D413/04 ,  C07D261/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04

摘要： The present invention relates to isoxazoline derivatives and their analogues, which can be used as phosphodiesterase (PDE) type IV selective inhibitors. Compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases, especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and their use as PDE type IV selective inhibitors, are provided.

摘要翻译： 本发明涉及可用作磷酸二酯酶（PDE）IV型选择性抑制剂的异恶唑啉衍生物及其类似物。 本文公开的化合物可用于治疗AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS），嗜酸粒细胞性肉芽肿， 过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。 提供制备所公开化合物的方法，含有所公开化合物的药物组合物及其作为PDE IV型选择性抑制剂的用途。