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1.发明授权公开(公告)号：US09581797B2
公开(公告)日：2017-02-28
申请号：US15180301
申请日：2016-06-13
Applicant: Verily Life Sciences LLC
Inventor： Victor Marcel Acosta , Adam Backer , John D. Perreault , Daniele Paolo Piponi
IPC: G01J3/28 , G02B21/00 , G01J3/02 , G01N21/25 , G02B21/36 , G01J3/18 , G02F1/1335 , G02F1/29 , G02B5/18 , G02B26/08 , G01N21/27 , G02B21/06 , G02F1/23 , G06T7/00 , G06T7/40 , H04N5/225 , H04N5/33 , G01J3/50 , G01J3/12 , G01J3/46 , G02B6/293
CPC classification number: G02B21/0064 , G01J3/0205 , G01J3/021 , G01J3/0229 , G01J3/0237 , G01J3/18 , G01J3/502 , G01J2003/1278 , G01J2003/468 , G01N21/255 , G01N21/27 , G01N2201/06113 , G01N2201/0675 , G02B5/1828 , G02B6/2931 , G02B21/06 , G02B21/361 , G02B26/0808 , G02F1/133553 , G02F1/23 , G02F1/292 , G06T7/11 , G06T7/90 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064 , G06T2207/30004 , H04N5/2256 , H04N5/332
Abstract: An imaging system includes a light source configured to illuminate a target and a camera configured to image light responsively emitted from the target and reflected from a spatial light modulator (SLM). The imaging system is configured to generate high-resolution, hyperspectral images of the target. The SLM includes a refractive layer that is chromatically dispersive and that has a refractive index that is controllable. The refractive index of the refractive layer can be controlled to vary according to a gradient such that light reflected from the SLM is chromatically dispersed and spectrographic information about the target can be captured using the camera. Such a system could be operated confocally, e.g., by incorporating a micromirror device configured to control a spatial pattern of illumination of the target and to modulate the transmission of light from the target to the camera via the SLM according to a corresponding spatial pattern.
Abstract translation: 成像系统包括被配置为照射目标的光源和被配置为对从目标发射并从空间光调制器（SLM）反射的）反射的图像的照相机。 成像系统被配置为产生目标的高分辨率，高光谱图像。 SLM包括色度分散且具有可控制的折射率的折射层。 折射层的折射率可以根据梯度来变化，使得从SLM反射的光被色散，并且可以使用照相机捕获关于目标的光谱信息。 这样的系统可以协调地操作，例如通过结合配置成控制目标的照明的空间模式的微镜装置，并且根据对应的空间模式经由SLM调制从目标到照相机的光的传输。
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公开(公告)号：US20200182793A1
公开(公告)日：2020-06-11
申请号：US16788730
申请日：2020-02-12
Applicant: Verily Life Sciences LLC
Inventor： Cheng-Hsun Wu , Brian M. Rabkin , Supriyo Sinha , John D. Perreault , Chinmay Belthangady , James Higbie , Seung Ah Lee
Abstract: The present disclosure relates to systems and methods for cellular imaging and identification through the use of a light sheet flow cytometer. In one implementation, a light sheet flow cytometer may include a light source configured to emit light having one or more wavelengths, at least one optical element configured to form a light sheet from the emitted light, a microfluidic channel configured to hold a sample, and an imaging device. The imaging device may be adapted to forming 3-D images of the sample such that identification tags attached to the sample are visible.
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公开(公告)号：US10605733B1
公开(公告)日：2020-03-31
申请号：US15833677
申请日：2017-12-06
Applicant: Verily Life Sciences LLC
Inventor： Cheng-Hsun Wu , Brian M. Rabkin , Supriyo Sinha , John D. Perreault , Chinmay Belthangady , James Higbie , Seung Ah Lee
Abstract: The present disclosure relates to systems and methods for cellular imaging and identification through the use of a light sheet flow cytometer. In one implementation, a light sheet flow cytometer may include a light source configured to emit light having one or more wavelengths, at least one optical element configured to form a light sheet from the emitted light, a microfluidic channel configured to hold a sample, and an imaging device. The imaging device may be adapted to forming 3-D images of the sample such that identification tags attached to the sample are visible.
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4.发明申请High-Throughput Hyperspectral Imaging With Superior Resolution And Optical Sectioning 审中-公开高分辨率高分辨率高光谱成像技术公开(公告)号：US20160282594A1
公开(公告)日：2016-09-29
申请号：US15180301
申请日：2016-06-13
Applicant: Verily Life Sciences LLC
Inventor： Victor Marcel Acosta , Adam Backer , John D. Perreault , Daniele Paolo Piponi
IPC: G02B21/00 , H04N5/33 , G06T7/40 , G02F1/23 , G02B21/06 , G02B21/36 , G01N21/27 , H04N5/225 , G06T7/00
CPC classification number: G02B21/0064 , G01J3/0205 , G01J3/021 , G01J3/0229 , G01J3/0237 , G01J3/18 , G01J3/502 , G01J2003/1278 , G01J2003/468 , G01N21/255 , G01N21/27 , G01N2201/06113 , G01N2201/0675 , G02B5/1828 , G02B6/2931 , G02B21/06 , G02B21/361 , G02B26/0808 , G02F1/133553 , G02F1/23 , G02F1/292 , G06T7/11 , G06T7/90 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064 , G06T2207/30004 , H04N5/2256 , H04N5/332
Abstract: An imaging system includes a light source configured to illuminate a target and a camera configured to image light responsively emitted from the target and reflected from a spatial light modulator (SLM). The imaging system is configured to generate high-resolution, hyperspectral images of the target. The SLM includes a refractive layer that is chromatically dispersive and that has a refractive index that is controllable. The refractive index of the refractive layer can be controlled to vary according to a gradient such that light reflected from the SLM is chromatically dispersed and spectrographic information about the target can be captured using the camera. Such a system could be operated confocally, e.g., by incorporating a micromirror device configured to control a spatial pattern of illumination of the target and to modulate the transmission of light from the target to the camera via the SLM according to a corresponding spatial pattern.
Abstract translation: 成像系统包括被配置为照射目标的光源和被配置为对从目标发射并从空间光调制器（SLM）反射的）反射的图像的照相机。 成像系统被配置为产生目标的高分辨率，高光谱图像。 SLM包括色度分散且具有可控制的折射率的折射层。 折射层的折射率可以根据梯度来变化，使得从SLM反射的光被色散，并且可以使用照相机捕获关于目标的光谱信息。 这样的系统可以协调地操作，例如通过结合配置成控制目标的照明的空间模式的微镜装置，并且根据对应的空间模式经由SLM调制从目标到照相机的光的传输。
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公开(公告)号：US10338275B1
公开(公告)日：2019-07-02
申请号：US15166908
申请日：2016-05-27
Applicant: Verily Life Sciences LLC
Inventor： Victor Marcel Acosta , James Michael Higbie , Supriyo Sinha , Eden Rephaeli , Andrew Homyk , John D. Perreault
IPC: G02F1/11 , G02B26/02 , G02F1/01 , G02B26/00 , G02B1/00 , G02B5/28 , G02B27/50 , G02B13/00 , H04N5/33 , H04N5/238
Abstract: Systems and methods are described that relate to a nanophotonic optical system. The nanophotonic optical system may be configured to transmit light in a range of wavelengths. The nanophotonic optical system includes at least one nanophotonic element, which includes a two-dimensional arrangement of sub-wavelength regions of a first material interspersed within a second material, the first and second materials having different indices of refraction. The at least one nanophotonic element includes a surface having a curvature and an optical phase transfer function dependent on the curvature of the surface. The nanophotonic optical system includes an actuator configured to modify the curvature of the surface and a controller. The controller is configured to determine a threshold optical phase transfer function and cause the actuator to modify the curvature of the surface to provide the threshold optical phase transfer function.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20170343824A1
公开(公告)日：2017-11-30
申请号：US15481385
申请日：2017-04-06
Applicant: Verily Life Sciences LLC
Inventor： Supriyo Sinha , John D. Perreault , Cheng-Hsun Wu
CPC classification number: G02B27/0062 , G02B5/04
Abstract: Systems and methods for dispersing an optical beam are disclosed. In one implementation, an optical system includes a first double Amici prism and a second double Amici prism. The first and second double Amici prisms are aligned along an optical axis of the system and configured to transmit the optical beam. At least one of the first and second double Amici prisms is rotatable relative to the other around the optical axis. Advantageously, the disclosed systems and methods allow for efficient and versatile adjustment of the magnitude and/or orientation of the dispersion of the optical beam.
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公开(公告)号：US20170296110A1
公开(公告)日：2017-10-19
申请号：US15098686
申请日：2016-04-14
Applicant: Verily Life Sciences LLC
Inventor： Chinmay Belthangady , Faisal Kashif , Seung Ah Lee , Tamara Troy , John D. Perreault , Suresh Alla
CPC classification number: A61B5/14552 , A61B5/0022 , A61B5/0073 , A61B5/0075 , A61B5/14546 , A61B2562/0238 , G06F19/00 , G16H40/67 , H04N5/33 , H04N5/372 , H04N5/374
Abstract: A device and a method to measure the concentrations of oxygenated and deoxygenated hemoglobin in tissue around a tumor via near-infrared (NIR) spectroscopy with a photonic mixer device (PMD) is described.
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公开(公告)号：US09788770B1
公开(公告)日：2017-10-17
申请号：US15098686
申请日：2016-04-14
Applicant: Verily Life Sciences LLC
Inventor： Chinmay Belthangady , Faisal Kashif , Seung Ah Lee , Tamara Troy , John D. Perreault , Suresh Alla
CPC classification number: A61B5/14552 , A61B5/0022 , A61B5/0073 , A61B5/0075 , A61B5/14546 , A61B2562/0238 , G06F19/00 , G16H40/67 , H04N5/33 , H04N5/372 , H04N5/374
Abstract: A device and a method to measure the concentrations of oxygenated and deoxygenated hemoglobin in tissue around a tumor via near-infrared (NIR) spectroscopy with a photonic mixer device (PMD) is described.
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公开(公告)号：US20160202178A1
公开(公告)日：2016-07-14
申请号：US14594956
申请日：2015-01-12
Applicant: Verily Life Sciences LLC
Inventor： Victor Marcel Acosta , Adam Backer , John D. Perreault , Daniele Paolo Piponi
CPC classification number: G02B21/0064 , G01J3/0205 , G01J3/021 , G01J3/0229 , G01J3/0237 , G01J3/18 , G01J3/502 , G01J2003/1278 , G01J2003/468 , G01N21/255 , G01N21/27 , G01N2201/06113 , G01N2201/0675 , G02B5/1828 , G02B6/2931 , G02B21/06 , G02B21/361 , G02B26/0808 , G02F1/133553 , G02F1/23 , G02F1/292 , G06T7/11 , G06T7/90 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064 , G06T2207/30004 , H04N5/2256 , H04N5/332
Abstract: An imaging system includes a light source configured to illuminate a target and a camera configured to image light responsively emitted from the target and reflected from a spatial light modulator (SLM). The imaging system is configured to generate high-resolution, hyperspectral images of the target. The SLM includes a refractive layer that is chromatically dispersive and that has a refractive index that is controllable. The refractive index of the refractive layer can be controlled to vary according to a gradient such that light reflected from the SLM is chromatically dispersed and spectrographic information about the target can be captured using the camera. Such a system could be operated confocally, e.g., by incorporating a micromirror device configured to control a spatial pattern of illumination of the target and to modulate the transmission of light from the target to the camera via the SLM according to a corresponding spatial pattern.
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公开(公告)号：US11428633B2
公开(公告)日：2022-08-30
申请号：US16788730
申请日：2020-02-12
Applicant: Verily Life Sciences LLC
Inventor： Cheng-Hsun Wu , Brian M. Rabkin , Supriyo Sinha , John D. Perreault , Chinmay Belthangady , James Higbie , Seung Ah Lee
Abstract: The present disclosure relates to systems and methods for cellular imaging and identification through the use of a light sheet flow cytometer. In one implementation, a light sheet flow cytometer may include a light source configured to emit light having one or more wavelengths, at least one optical element configured to form a light sheet from the emitted light, a microfluidic channel configured to hold a sample, and an imaging device. The imaging device may be adapted to forming 3-D images of the sample such that identification tags attached to the sample are visible.
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