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公开(公告)号：US20230416275A1
公开(公告)日：2023-12-28
申请号：US18030537
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Mark Thomas MILLER , Alina SILINA , Jinglan ZHOU
IPC分类号： C07D515/18 , C07D515/22 , C07D515/08 , A61K45/06
CPC分类号： C07D515/18 , C07D515/22 , C07D515/08 , A61K45/06 , C07B2200/09
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.
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公开(公告)号：US20230373939A1
公开(公告)日：2023-11-23
申请号：US18030519
申请日：2021-10-06
发明人： Jason MCCARTNEY , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Mark Thomas MILLER , Alina SILINA , Jinglan ZHOU
IPC分类号： C07D279/06 , C07D241/22 , C07D251/24 , C07D239/69 , C07D403/04 , C07D213/76 , C07D401/14 , C07D401/12 , A61K45/06
CPC分类号： C07D279/06 , C07D241/22 , C07D251/24 , C07D239/69 , C07D403/04 , C07D213/76 , C07D401/14 , C07D401/12 , A61K45/06 , C07B2200/05
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.
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公开(公告)号：US20230374038A1
公开(公告)日：2023-11-23
申请号：US18248068
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy Richard COON , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Paul KRENITSKY , Mark Thomas MILLER , Prasuna PARASELLI , Fabrice PIERRE , Alina SILINA , Joe A. TRAN , Jinglan ZHOU
IPC分类号： C07D515/08 , A61K45/06 , C07D515/18 , A61K31/529 , A61K31/5377
CPC分类号： C07D515/08 , A61K45/06 , C07D515/18 , A61K31/529 , A61K31/5377
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of mediated diseases, such as cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and therapies comprising such modulators, and processes and intermediates for making such modulators.
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公开(公告)号：US20190016671A1
公开(公告)日：2019-01-17
申请号：US16032799
申请日：2018-07-11
发明人： Nadia AHMAD , Corey ANDERSON , Vijayalaksmi ARUMUGAM , Iuliana Luci ASGIAN , Joanne Louise CAMP , Lev Tyler Dewey FANNING , Sara Sabina HADIDA RUAH , Dennis HURLEY , Yvonne SCHMIDT , David SHAW , Urvi Jagdishbhai SHETH , Stephen Andrew THOMSON
IPC分类号： C07C235/64 , C07D213/81 , C07D213/89 , C07D239/34 , C07D317/46 , C07D405/12 , C07D213/69 , C07D213/82 , C07D307/79
摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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公开(公告)号：US20170145011A1
公开(公告)日：2017-05-25
申请号：US15369029
申请日：2016-12-05
发明人： Sara Sabina HADIDA RUAH , Edward Adam KALLEL , Mark Thomas MILLER , Vijayalaksmi ARUMUGAM , Jason McCARTNEY , Corey ANDERSON , Peter Diederik Jan GROOTENHUIS , Licong JIANG
IPC分类号： C07D471/20 , A61K31/499
CPC分类号： C07D471/20 , A61K31/499 , A61K31/506 , C07D519/00
摘要： The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20240150377A1
公开(公告)日：2024-05-09
申请号：US18248071
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy Richard COON , Timothy A. DWIGHT , Lev Tyler Dewey FANNING , Bryan A. FRIEMAN , Peter GROOTENHUIS , Anton V. GULEVICH , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Paul KRENITSKY , Vito MELILLO , Mark Thomas MILLER , Prasuna PARASELLI , Fabrice PIERRE , Alina SILINA , Joe A. TRAN , Johnny UY , Lino VALDEZ , Troy VICKERS , Jinglan ZHOU
IPC分类号： C07D515/08 , A61K31/404 , A61K31/47 , A61K31/529
CPC分类号： C07D515/08 , A61K31/404 , A61K31/47 , A61K31/529
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.
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公开(公告)号：US20230382924A1
公开(公告)日：2023-11-30
申请号：US18030527
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Paul KRENITSKY , Mark Thomas MILLER , Fabrice PIERRE , Alina SILINA , Johnny UY , Jinglan Zhou
IPC分类号： C07D515/08 , C07F7/08 , C07F9/6561 , C07D515/18 , C07D515/20 , C07D519/00 , A61K31/47 , A61K31/529 , A61K31/695 , A61K31/675 , A61K31/5377 , A61K31/541
CPC分类号： C07D515/08 , C07F7/0812 , C07F9/6561 , C07D515/18 , C07D515/20 , C07D519/00 , A61K31/47 , A61K31/529 , A61K31/695 , A61K31/675 , A61K31/5377 , A61K31/541 , C07B2200/09
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.
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公开(公告)号：US20220372047A1
公开(公告)日：2022-11-24
申请号：US17600829
申请日：2020-04-02
发明人： Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy A. DWIGHT , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Paul KRENITSKY , Jason MCCARTNEY , Vito MELILLO , Mark Thomas MILLER , Alina SILINA , Johnny UY , Jinglan ZHOU
IPC分类号： C07D515/08 , C07D239/69 , C07D215/233 , C07D405/12
摘要： Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.
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9.发明申请公开(公告)号：US20150025073A1
公开(公告)日：2015-01-22
申请号：US14454227
申请日：2014-08-07
发明人： Sara Sabina Hadida-Ruah , Hayley Marie Binch , Michael Paul DeNinno , Lev Tyler Dewey Fanning , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Nicole Hilgraf , Pramod Joshi , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Alina Silina , Urvi Jagdishbhai Sheth , Dennis James Hurley , Vijayalaksmi ARUMUGAM
IPC分类号： C07D498/10
CPC分类号： C07D498/10
摘要： The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的吗啉螺环哌啶酰胺化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20240018161A1
公开(公告)日：2024-01-18
申请号：US18030530
申请日：2021-10-06
发明人： Jason MCCARTNEY , Alexander Russell ABELA , Sunny ABRAHAM , Corey Don ANDERSON , Vijayalaksmi ARUMUGAM , Jaclyn CHAU , Jeremy CLEMENS , Thomas CLEVELAND , Timothy Richard COON , Andrew DINH , Timothy A. DWIGHT , Lev Tyler Dewey FANNING , Bryan A. FRIEMAN , Peter GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Paul KRENITSKY , Mark Thomas MILLER , Fabrice PIERRE , Alina SILINA , Joe A. TRAN , Lino VALDEZ , Jinglan ZHOU
IPC分类号： C07D515/04 , C07D515/14 , A61K45/06
CPC分类号： C07D515/04 , A61K45/06 , C07D515/14
摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.
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