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公开(公告)号：US08366086B2
公开(公告)日：2013-02-05
申请号：US12625095
申请日：2009-11-24
CPC分类号： A61M39/221 , A61M2039/222 , A61M2209/04 , Y10T29/53
摘要： A hand held opener for opening a frangible closer comprising a handle adapted to be gripped by an operator, a motion actuator operatively connected to the handle, a first shaft connected to the motion actuator, a second shaft connected to the motion actuator, a first gripper portion on the first shaft adapted to grip the frangible closer in a first location, and a second gripper portion on the second shaft adapted to grip the frangible closer in a second location wherein the motion actuator provides reciprocal movement to the shafts to rotate the frangible closer in one direction and to rotate the frangible closer in a direction opposite the first direction.
摘要翻译： 用于打开易碎的靠近器的手持式开启器，包括适于被操作者抓握的手柄，可操作地连接到手柄的运动致动器，连接到运动致动器的第一轴，连接到运动致动器的第二轴，第一夹持器 第一轴上的部分适于在第一位置抓握易碎的靠近器，以及在第二轴上的第二夹持器部分，其适于在第二位置夹紧易碎的靠近器，其中运动致动器提供往复运动以使所述易碎的接近器 在一个方向上并沿与第一方向相反的方向旋转易碎的近端。
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公开(公告)号：US07897054B2
公开(公告)日：2011-03-01
申请号：US12454839
申请日：2009-05-21
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B01D17/038
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B2005/045
摘要： A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
摘要翻译： 一种用于接收和保持流体样品的柔性一次性离心机袋，包括一个或多个管和具有环形构型的上下柔性片。 上片和下片在其外周叠加并完全密封在一起以限定离心机袋的外周。 袋的内周界定中心芯。 管夹在上下片之间并从离心机袋的中心芯延伸。 上下板在其内周边密封在一起，使得管在内周边处密封在所述上板和下板之间。 该袋可以用于以批量方法从全血中收集富含血小板的血浆，或者在离心过程中同时将额外的全血量等分进入袋中。
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3.发明授权Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma 有权离心机系统利用一次性部件和自动处理血液来收集血小板富集血浆公开(公告)号：US07867159B2
公开(公告)日：2011-01-11
申请号：US11810071
申请日：2007-06-04
申请人： Victor D. Dolecek , Gary L. Berg , Kenneth E. Merte , David Malcolm , Kevin D. McIntosh , Vitaly G. Sitko
发明人： Victor D. Dolecek , Gary L. Berg , Kenneth E. Merte , David Malcolm , Kevin D. McIntosh , Vitaly G. Sitko
IPC分类号： B04B11/00
CPC分类号： A61M1/3693 , A61M1/1081 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2205/331 , B04B5/0442 , B04B7/02 , B04B13/00 , A61M2202/0092
摘要： A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.
摘要翻译： 一种离心法和相应的系统，用于处理血液以收集血小板富集血浆。 通过以填充旋转速度旋转分离室并从填充注射器泵送血液，从填充注射器中填充分离室。 软旋转用于通过以柔软的旋转速率旋转分离室来最初将红细胞与血小板分离。 将血液的一部分从分离室抽出回填充注射器以除去分离的红细胞。 分离出的血液的第二部分从分离室抽出直到检测到红细胞/血小板界面。 通过以更高的速率旋转分离室来进行硬旋转，并且通过绘制预定的清除体积来连接管被清除红细胞。 然后将富血小板血浆收集在收集注射器中。
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公开(公告)号：US07635343B2
公开(公告)日：2009-12-22
申请号：US11341153
申请日：2006-01-27
IPC分类号： A61M37/00
CPC分类号： A61M5/19 , A61B17/00491 , A61B2017/00495 , A61M2205/6081 , B01F5/0256 , B05C17/00553
摘要： Dispensing assemblies, methods, and kits of parts for dispensing two separate fluids to an treatment site, including entraining non-atomized flow of a first fluid in an atomized flow of a second fluid, delivering a first fluid upstream from a second fluid, delivering a first fluid and a second fluid with re-shapeable malleable tubes, delivering first and second fluids with releasable connectors maintained by a handle assembly, and kits of parts with angularly offset pockets.
摘要翻译： 用于将两个分离的流体分配到处理部位的分配组件，方法和套件，包括夹带第二流体的雾化流中的第一流体的非雾化流，从第二流体上游输送第一流体， 第一流体和具有可重塑的可延展管的第二流体，通过由手柄组件保持的具有可释放连接器的第一和第二流体以及具有角度偏移的袋的部件套件递送。
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公开(公告)号：US20080171646A1
公开(公告)日：2008-07-17
申请号：US12001257
申请日：2007-12-10
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B04B7/12
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B2005/045
摘要： A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
摘要翻译： 一种用于接收和保持流体样品的柔性一次性离心机袋，包括一个或多个管和具有环形构型的上下柔性片。 上片和下片在其外周叠加并完全密封在一起以限定离心机袋的外周。 袋的内周界定中心芯。 管夹在上下片之间并从离心机袋的中心芯延伸。 上下板在其内周边密封在一起，使得管在内周边处密封在所述上板和下板之间。 该袋可以用于以批量方法从全血中收集富含血小板的血浆，或者在离心过程中同时将额外的全血量等分进入袋中。
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公开(公告)号：US06951612B2
公开(公告)日：2005-10-04
申请号：US10408406
申请日：2003-04-07
申请人： Victor D. Dolecek
发明人： Victor D. Dolecek
IPC分类号： A61M1/36 , B01D17/038 , B04B5/04 , B04B9/08 , B04B15/00
CPC分类号： B04B9/08 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , B04B5/0442
摘要： A centrifuge system with an externally positioned sensor assembly for detecting the separation of components in a fluid sample, such as platelets in a blood sample. The system includes a centrifuge with a drive portion and a rotor portion with a sample reservoir or centrifuge bag for receiving and containing a fluid sample during rotation of the rotor portion. An external sensor assembly is positioned relative to the centrifuge to direct a radiation beam from a radiation source through the rotor portion and the centrifuge bag and to allow a detector to receive the lower-intensity radiation beams at a location external to the rotor portion. In one embodiment, the rotor portion is fabricated from a transparent material and extends radially outward from the sides of the drive portion to allow the radiation source and detector to be positioned externally on opposing sides of the extending rotor portion.
摘要翻译： 一种具有外部定位的传感器组件的离心机系统，用于检测流体样品（例如血液样品中的血小板）中的组分的分离。 该系统包括具有驱动部分的离心机和具有用于在转子部分旋转期间接收和容纳流体样品的样品容器或离心机袋的转子部分。 外部传感器组件相对于离心机定位以将来自辐射源的辐射束引导通过转子部分和离心机袋，并允许检测器在转子部分外部的位置处接收较低强度的辐射束。 在一个实施例中，转子部分由透明材料制成并且从驱动部分的侧面径向向外延伸，以允许辐射源和检测器在外部位于延伸转子部分的相对侧上。
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公开(公告)号：US06793828B2
公开(公告)日：2004-09-21
申请号：US10431894
申请日：2003-05-08
IPC分类号： B01D1738
CPC分类号： B04B5/0428 , B04B5/0442 , B04B2005/045
摘要： A centrifugal method of separating and collecting components from a fluid is provided, comprising providing a centrifuge operable at a plurality of rotation speeds and having a mounting assembly for positioning and retaining a disposable collection assembly relative to the centrifuge at the rotation speeds; mounting a separation assembly comprising a number of collection chambers in the mounting assembly, wherein each of the collection chambers include an outer, conical-shaped collection portion with a port for providing a fluid pathway for the fluid into and out of the collection chambers and wherein the mounting includes fluidically connecting the ports with a fluid tube; connecting a fluid source to the fluid tube; rotating the centrifuge at a fill speed; and operating the fluid source to supply the fluid to the fluid tube, whereby the fluid is concurrently supplied in substantially equal volumetric and component density quantities to each of the collection chambers.
摘要翻译： 提供了一种从流体分离和收集部件的离心方法，包括提供可以多个旋转速度操作的离心机，并具有安装组件，用于以一定速度相对于离心机定位和保持一次性收集组件; 将包括多个收集室的分离组件安装在所述安装组件中，其中每个所述收集室包括具有端口的外部圆锥形收集部分，所述端口用于提供流体进入和离开所述收集室的流体路径，并且其中 安装件包括使端口与流体管流体连接; 将流体源连接到流体管; 以填充速度旋转离心机; 并且操作所述流体源以将流体供应到所述流体管，由此所述流体同时以基本相等的体积和组分密度数量供应到每个所述收集室。
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公开(公告)号：US06612975B2
公开(公告)日：2003-09-02
申请号：US09832730
申请日：2001-04-09
申请人： David Malcom , Victor D. Dolecek
发明人： David Malcom , Victor D. Dolecek
IPC分类号： B04B900
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/331 , B04B5/0442 , B04B9/08 , B04B2005/045
摘要： A blood centrifuge with a drive assembly for transmitting an input rotation speed to a rotor with a sample reservoir at a desired rotation ratio. The drive assembly includes a base and an outer shell mounted to the base to rotate at an input rate. A bottom pulley is rigidly mounted to the base and attached to the outer shell with bearings. A top pulley is mounted to a center shaft of the outer shell to rotate with the outer shell about the central axis of the centrifuge. An internal drive belt is provided to transmit the rotation to the top pulley via a pair of transversely mounted idler pulleys that rotate with the outer shell. The top pulley is thus rotated at twice the input rate but in the same direction. A rotor assembly with the sample reservoir is attached to the top pulley to separate blood components.
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公开(公告)号：US06582350B2
公开(公告)日：2003-06-24
申请号：US09833231
申请日：2001-04-09
申请人： Victor D. Dolecek
发明人： Victor D. Dolecek
IPC分类号： B04B712
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045
摘要： A rigid centrifuge container for separating components of a fluid, comprising a rigid annular body having an axial core and an interior collection chamber for receiving and holding the fluid during centrifugation. The chamber has a generally off-centered figure eight-shaped side cross-sectional configuration, wherein the narrowest portion of the chamber is closer to the inner perimeter. The chamber further has an inlet channel extending radially from the core to a distance near the outer perimeter of the chamber, and an outlet channel extending radially from the core to a distance approximately near the narrowest portion of the chamber. The distal end of the inlet channel is in fluid communication with the interior of the chamber, and the distal end of the outlet channel is in fluid communication with the interior of the chamber at the narrowest portion.
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公开(公告)号：US07766809B2
公开(公告)日：2010-08-03
申请号：US11954360
申请日：2007-12-12
CPC分类号： A61M1/3693 , A61M1/0218 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2202/0439 , A61M2205/3365 , B04B5/0428 , B04B9/14 , B04B2009/143 , B04B2013/006
摘要： A method for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising centrifuging at least two separation bags containing two discrete volumes of a composite liquid respectively, so as to separate therein the first and second components; transferring at least one fraction of a first separated component from the separation bags into satellite bags connected thereto respectively; detecting a characteristic of a component at determined location in each separation bag; and stopping transferring the at least one fraction of the first component from each separation bag into the first satellite bag connected thereto, upon detection of the characteristic of a component at the determined location.
摘要翻译： 一种用于将至少两个离散体积的复合液体分离成至少第一组分和第二组分的方法，包括分别离心分离含有两个离散体积的复合液体的至少两个分离袋，以便在其中分离第一和第二组分 组件; 将来自分离袋的至少一部分第一分离组分转移到分别与其连接的卫星袋中; 检测每个分离袋中的确定位置处的部件的特性; 并且在检测到所确定的位置处的部件的特性时，停止将来自每个分离袋的第一部件的至少一部分转移到与其连接的第一卫星袋中。
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