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公开(公告)号：US20110282110A1
公开(公告)日：2011-11-17
申请号：US13079700
申请日：2011-04-04
申请人： Victor J. Johnston , Barbara Kimmich , John Potts , Heiko Weiner , James H. Zink , Josefina T. Chapman , Laiyuan Chen , Radmila Jevtic
发明人： Victor J. Johnston , Barbara Kimmich , John Potts , Heiko Weiner , James H. Zink , Josefina T. Chapman , Laiyuan Chen , Radmila Jevtic
IPC分类号： C07C29/149
CPC分类号： C07C29/149 , B01J21/16 , B01J23/6522 , C07C31/08
摘要： Catalysts and processes for forming catalysts for use in hydrogenating acetic acid to form ethanol. The catalyst comprises palladium and chromium on a support.
摘要翻译： 用于形成用于氢化乙酸形成乙醇的催化剂的催化剂和方法。 催化剂在载体上包含钯和铬。
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公开(公告)号：US20110263910A1
公开(公告)日：2011-10-27
申请号：US13079704
申请日：2011-04-04
申请人： Victor J. Johnston , Barbara Kimmich , John Potts , Heiko Weiner , James H. Zink , Josefina T. Chapman , Laiyuan Chen , Radmila Jevtic
发明人： Victor J. Johnston , Barbara Kimmich , John Potts , Heiko Weiner , James H. Zink , Josefina T. Chapman , Laiyuan Chen , Radmila Jevtic
IPC分类号： C07C27/04
CPC分类号： C07C29/149 , B01J21/16 , B01J23/44 , B01J23/58 , B01J23/72 , B01J23/8926 , C07C31/08
摘要： Catalysts and processes for forming copper catalysts for use in hydrogenating acetic acid to form ethanol. The catalyst may also comprise a second metal selected from the group consisting of chromium, palladium, platinum, rhodium, ruthenium, silver, tungsten, vanadium, and zinc.
摘要翻译： 用于形成用于氢化乙酸形成乙醇的铜催化剂的催化剂和方法。 催化剂还可以包含选自铬，钯，铂，铑，钌，银，钨，钒和锌的第二金属。
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公开(公告)号：US08338650B2
公开(公告)日：2012-12-25
申请号：US13079700
申请日：2011-04-04
申请人： Victor J. Johnston , Barbara Kimmich , John Potts , Heiko Weiner , James H. Zink , Josefina T. Chapman , Laiyuan Chen , Radmila Jevtic
发明人： Victor J. Johnston , Barbara Kimmich , John Potts , Heiko Weiner , James H. Zink , Josefina T. Chapman , Laiyuan Chen , Radmila Jevtic
IPC分类号： C07C29/149
CPC分类号： C07C29/149 , B01J21/16 , B01J23/6522 , C07C31/08
摘要： Catalysts and processes for forming catalysts for use in hydrogenating acetic acid to form ethanol. The catalyst comprises palladium and chromium on a support.
摘要翻译： 用于形成用于氢化乙酸形成乙醇的催化剂的催化剂和方法。 催化剂在载体上包含钯和铬。
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公开(公告)号：US20120010441A1
公开(公告)日：2012-01-12
申请号：US13078727
申请日：2011-04-01
IPC分类号： C07C29/149
摘要： Monitoring and recycling gases from acetic acid hydrogenation reaction to maintain a constant pressure in the hydrogenation reaction system. Purging of the vapor stream comprising hydrogen may be limited or reduced. Further purging of the by-product may be from the dissolved by-product gases.
摘要翻译： 监测和回收来自乙酸氢化反应的气体，以保持氢化反应体系中的恒定压力。 可以限制或减少包含氢气的蒸气流的净化。 副产物的进一步吹扫可能来自溶解的副产物气体。
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公开(公告)号：US08575404B2
公开(公告)日：2013-11-05
申请号：US13078727
申请日：2011-04-01
IPC分类号： C07C29/149
摘要： Monitoring and recycling gases from acetic acid hydrogenation reaction to maintain a constant pressure in the hydrogenation reaction system. Purging of the vapor stream comprising hydrogen may be limited or reduced. Further purging of the by-product may be from the dissolved by-product gases.
摘要翻译： 监测和回收来自乙酸氢化反应的气体，以保持氢化反应体系中的恒定压力。 可以限制或减少包含氢气的蒸气流的净化。 副产物的进一步吹扫可能来自溶解的副产物气体。
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公开(公告)号：US20070117969A1
公开(公告)日：2007-05-24
申请号：US11644002
申请日：2006-12-22
申请人： Thomas Gardella , Henry Kronenberg , John Potts
发明人： Thomas Gardella , Henry Kronenberg , John Potts
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/72 , C07K2319/00 , G01N33/5008 , G01N33/5038 , G01N33/5044 , G01N2333/72
摘要： The invention provides a novel PTH receptor polypeptide, rΔNt, characterized by a deletion of the extracellular amino-terminus, ligand binding domain of the receptor. Additionally disclosed are nucleic acid molecules encoding the receptor. The receptor has a minimal domain for ligand binding and is useful in screening assays designed for the identification of agonists and antagonists of PTH receptor activity.
摘要翻译： 本发明提供了新的PTH受体多肽rDeltaNt，其特征在于受体的细胞外氨基末端，配体结合结构域的缺失。 另外公开了编码受体的核酸分子。 该受体具有用于配体结合的最小结构域，并且可用于设计用于鉴定PTH受体活性的激动剂和拮抗剂的筛选测定。
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公开(公告)号：US20060078831A1
公开(公告)日：2006-04-13
申请号：US11282927
申请日：2005-11-18
IPC分类号： G03C5/00
CPC分类号： G02B6/10 , B33Y80/00 , G02B6/1221 , G02B6/13 , G02B6/138 , G02B2006/121 , G02B2006/12102 , G02B2006/12107 , G02B2006/12147 , G02B2006/1215 , G03C5/00 , G03F7/0005 , G03F7/031 , G03F7/2053 , G03H2001/0484 , Y10S430/146 , Y10T428/31667
摘要： Methods of fabricating optical elements that are encapsulated in monolithic matrices. The present invention is based, at least in one aspect, upon the concept of using multiphoton, multi-step photocuring to fabricate encapsulated optical element(s) within a body of a photopolymerizable composition. Imagewise, multi-photon polymerization techniques are used to form the optical element. The body surrounding the optical element is also photohardened by blanket irradiation and/or thermal curing to help form an encapsulating structure. In addition, the composition also incorporates one or more other, non-diffusing binder components that may be thermosetting or thermoplastic. The end result is an encapsulated structure with good hardness, durability, dimensional stability, resilience, and toughness.
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公开(公告)号：US20050272660A1
公开(公告)日：2005-12-08
申请号：US11176735
申请日：2005-07-08
申请人： Thomas Gardella , Henry Kronenberg , John Potts , Harald Juppner
发明人： Thomas Gardella , Henry Kronenberg , John Potts , Harald Juppner
IPC分类号： A61K38/00 , C07K14/635 , A61K38/22 , C12N1/21 , C12P21/06
CPC分类号： C07K14/635 , A61K38/00
摘要： Novel parathyroid hormone (PTH) polypeptide derivatives are disclosed, as are pharmaceutical compositions containing said polypeptides, and synthetic and recombinant methods for producing said polypeptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said polypeptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.
摘要翻译： 公开了新型甲状旁腺激素（PTH）多肽衍生物，含有所述多肽的药物组合物以及用于产生所述多肽的合成和重组方法。 还公开了使用含有所述多肽的治疗有效的药物组合物治疗哺乳动物状况的方法，其特征在于骨量减少。 还公开了用于筛选本发明的候选化合物对甲状旁腺激素受体作用的拮抗作用或激动作用的方法。 还公开了所述化合物的诊断和治疗方法。
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公开(公告)号：US20050203012A1
公开(公告)日：2005-09-15
申请号：US10959605
申请日：2004-10-07
IPC分类号： C12N15/09 , A61K38/00 , A61P19/10 , C07K14/635 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/16 , C12P21/02 , A61K38/17
CPC分类号： C07K14/635 , A61K38/00
摘要： Synthetic and/or recombinant biologically active peptide derivatives of PTH(1-28), comprising a biologically active peptide at least 90% identical to a peptide consisting essentially of the formula: (a)X01ValSerGluIleGlnLeuMetHisAsn(SEQ ID NO:1); LeuGlyLysHisLeuAsnSerMetX02Arg ValGluTrpLeuArgLysLysLeu (b) fragments thereof containing amino acids 1-24, 1-25, 1-26, or 1-27; (c) pharmaceutically acceptable salts thereof; or (d) N- or C-derivatives thereof; wherein: X01 is Ser, Ala or Gly; and X02 is Glu or Arg, provided that said peptide is not hPTH(1-26)NH2, hPTH(1-27)NH2 or hPTH(1-28)NH2.
摘要翻译： PTH（1-28）的合成和/或重组生物活性肽衍生物，其包含与基本上由下式构成的肽至少90％相同的生物活性肽：
< colspec colname =“1”colwidth =“14PT”align =“left”/> （a） X ValSerGluIleGlnLeuMetHisAsn （SEQ ID NO：1）; LeuGlyLysHisLeuAsnSerMetX Arg ROW> ValGluTrpLeuArgLysLysLeu （b）其含有氨基酸1-24,1 -25，1-26或1-27; （c）其药学上可接受的盐; 或（d）其N-或C-衍生物; 其中：X 0,1是Ser，Ala或Gly; 如果所述肽不是hPTH（1-26）NH 2，hPTH（1-27）NH 2，则X O 2是Glu或Arg， 或HPTH（1-28）NH 2。 -
公开(公告)号：US20050077513A1
公开(公告)日：2005-04-14
申请号：US10685049
申请日：2003-10-14
申请人： Xudong Fan , John Potts , Terry Smith , Robert Wilson
发明人： Xudong Fan , John Potts , Terry Smith , Robert Wilson
IPC分类号： G01N21/55 , G01N21/64 , G01N21/77 , G02B6/10 , G02B6/12 , G02B6/26 , G02B6/28 , G02B6/34 , G02B6/36 , E04D13/00
CPC分类号： G01N21/648 , G01N21/552 , G01N21/645 , G01N21/7746 , G01N2021/6484 , G02B6/12007 , G02B6/26 , G02B6/29341 , G02B6/3652 , G02B6/3692 , G02B6/4246 , G02F2203/15
摘要： Microresonators, such as a microsphere resonators and planar microresonators, are optically coupled to waveguides for input and output of light. It is important that the relative positions of the microresonator and the waveguide are maintained stable, while still maintaining high cavity Q and ease of launching and extracting the optical beams. Structures are provided on a substrate that are useful for maintaining the position of the microresonator relative to the waveguide. The structures provide for vertical or horizontal coupling between the waveguide and the microresonator.
摘要翻译： 诸如微球谐振器和平面微谐振器的微谐振器被光耦合到波导用于光的输入和输出。 重要的是，微谐振器和波导的相对位置保持稳定，同时仍然保持高腔Q并且容易发射和提取光束。 在基片上提供了可用于保持微谐振器相对于波导的位置的结构。 该结构提供波导和微谐振器之间的垂直或水平耦合。
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