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公开(公告)号：US07060436B2
公开(公告)日：2006-06-13
申请号：US09882945
申请日：2001-06-15
申请人： Victor Lyamichev , Hatim Allawi , Fang Dong , Bruce P. Neri , Tatiani I. Vener
发明人： Victor Lyamichev , Hatim Allawi , Fang Dong , Bruce P. Neri , Tatiani I. Vener
CPC分类号： C12Q1/6827 , C12Q1/6811 , C12Q1/686 , C12Q1/703 , C12Q2535/125 , C12Q2525/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid targets containing secondary structure.
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2.发明申请Nucleic Acid Accessible Hybridization Site Identification Using Mass Spectrometry 审中-公开使用质谱的核酸可接近杂交现场鉴定公开(公告)号：US20090075256A1
公开(公告)日：2009-03-19
申请号：US11763742
申请日：2007-06-15
CPC分类号： C12Q1/6832 , C12Q1/6811 , C12Q1/6848 , Y10T436/143333 , C12Q2565/627 , C12Q2565/133
摘要： The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes using mass spectrometry. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid targets containing secondary structure using mass spectrometry.
摘要翻译： 本发明涉及用于分析核酸的方法和组合物，特别涉及使用质谱法检测和表征核酸序列和序列变化的方法和组合物。 本发明还提供用于使用质谱法鉴定含有二级结构的核酸靶的具有期望的杂交性质的寡核苷酸的方法和组合物。
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公开(公告)号：US07824862B2
公开(公告)日：2010-11-02
申请号：US12242508
申请日：2008-09-30
申请人： Fang Dong , Victor I. Lyamichev , James R. Prudent , Lance Fors , Bruce P. Neri , Mary Ann D. Brow , Todd A. Anderson , James E. Dahlberg
发明人： Fang Dong , Victor I. Lyamichev , James R. Prudent , Lance Fors , Bruce P. Neri , Mary Ann D. Brow , Todd A. Anderson , James E. Dahlberg
CPC分类号： C12Q1/6832 , C12Q1/701 , C12Q2565/133 , C12Q2521/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸序列和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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4.发明授权Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides 失效通过结构桥接寡核苷酸的核酸结构探测进行多态性分析公开(公告)号：US06709819B2
公开(公告)日：2004-03-23
申请号：US09825574
申请日：2001-04-03
申请人： Victor I. Lyamichev , Fang Dong , Mary Ann D. Brow , Lance Fors , Bruce P. Neri
发明人： Victor I. Lyamichev , Fang Dong , Mary Ann D. Brow , Lance Fors , Bruce P. Neri
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , C12Q2565/133
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸序列和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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公开(公告)号：US06709815B1
公开(公告)日：2004-03-23
申请号：US09402618
申请日：2000-07-18
申请人： Fang Dong , Victor I. Lyamichev , James R. Prudent , Lance Fors , Bruce P. Neri , Mary Ann D. Brow , Todd A. Anderson , James E. Dahlberg
发明人： Fang Dong , Victor I. Lyamichev , James R. Prudent , Lance Fors , Bruce P. Neri , Mary Ann D. Brow , Todd A. Anderson , James E. Dahlberg
IPC分类号： C12Q168
CPC分类号： C07H21/04 , C07H21/02 , C12Q1/68 , C12Q1/6827 , Y02A90/26 , C12Q2565/131 , C12Q2565/501 , C12Q2565/625 , C12Q2565/133
摘要： The present invention relates to methods and compns. for treating nucleic acids, and in particular, methods and compns. for the detection and characterization of nucleic acid sequences and sequence changes. The invention provides methods for examg. the conformations assumed by single strands of nucleic acid, forming the basis of novel methods of detection of specific nucleic acid sequences. The present invention contemplates use of novel detection methods for, among other uses, clinical diagnostic purposes, including but not limited to the detection and identification of pathogenic organisms. Examples are presented for the analysis of Mycobacterium tuberculosis and hepatitis C virus genes.
摘要翻译： 本发明涉及方法和方法。 用于处理核酸，特别是方法和化合物。 用于检测和表征核酸序列和序列变化。 本发明提供了检查方法。 由单链核酸假设的构象，形成检测特异性核酸序列的新方法的基础。 本发明考虑使用新的检测方法用于临床诊断目的，包括但不限于病原体的检测和鉴定。 介绍了分析结核分枝杆菌和丙型肝炎病毒基因的实例。
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公开(公告)号：US20090117576A1
公开(公告)日：2009-05-07
申请号：US12242508
申请日：2008-09-30
申请人： Fang Dong , Victor I. Lyamichev , James R. Prudent , Lance Fors , Bruce P. Neri , Mary Ann D. Brow , Todd A. Anderson , James E. Dahlberg
发明人： Fang Dong , Victor I. Lyamichev , James R. Prudent , Lance Fors , Bruce P. Neri , Mary Ann D. Brow , Todd A. Anderson , James E. Dahlberg
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , C12Q1/701 , C12Q2565/133 , C12Q2521/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸序列和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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公开(公告)号：US07101672B2
公开(公告)日：2006-09-05
申请号：US10655362
申请日：2003-09-04
申请人： Fang Dong , Victor I. Lyamichev , James R. Prudent , Lance Fors , Bruce P. Neri , Mary Ann D. Brow , Todd A. Anderson , James E. Dahlberg
发明人： Fang Dong , Victor I. Lyamichev , James R. Prudent , Lance Fors , Bruce P. Neri , Mary Ann D. Brow , Todd A. Anderson , James E. Dahlberg
CPC分类号： C12Q1/6832 , C12Q1/701 , C12Q2565/133 , C12Q2521/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acids and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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8.发明授权Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides 失效通过结构桥接寡核苷酸的核酸结构探测进行多态性分析公开(公告)号：US06210880B1
公开(公告)日：2001-04-03
申请号：US08934097
申请日：1997-09-19
申请人： Victor I. Lyamichev , Fang Dong , Mary Ann D. Brow , Lance Fors , Bruce P. Neri
发明人： Victor I. Lyamichev , Fang Dong , Mary Ann D. Brow , Lance Fors , Bruce P. Neri
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , C12Q2565/133
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸序列和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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公开(公告)号：US07429455B2
公开(公告)日：2008-09-30
申请号：US11515854
申请日：2006-09-05
申请人： Fang Dong , Victor I. Lyamichev , James R. Prudent , Lance Fors , Bruce P. Neri , Mary Ann D. Brow , Todd A. Anderson , James E. Dahlberg
发明人： Fang Dong , Victor I. Lyamichev , James R. Prudent , Lance Fors , Bruce P. Neri , Mary Ann D. Brow , Todd A. Anderson , James E. Dahlberg
CPC分类号： C12Q1/6832 , C12Q1/701 , C12Q2565/133 , C12Q2521/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸序列和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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公开(公告)号：US06358691B1
公开(公告)日：2002-03-19
申请号：US09677192
申请日：2000-10-02
申请人： Bruce Neri , Fang Dong , Victor Lyamichev , Mary Ann D. Brow , Lance Fors
发明人： Bruce Neri , Fang Dong , Victor Lyamichev , Mary Ann D. Brow , Lance Fors
IPC分类号： C12Q168
CPC分类号： C12Q1/701 , C12Q1/6816 , C12Q2525/301 , C12Q2525/161 , C12Q2521/301
摘要： The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要翻译： 本发明涉及用于分析核酸的方法和组合物。 特别地，本发明提供了用于检测和表征核酸序列和序列变化的方法和组合物。 本发明的方法允许检测和/或鉴定遗传多态性，例如与人类疾病相关的遗传多态性，并允许鉴定病原体（例如病毒和细菌菌株鉴定）。
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