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公开(公告)号：US20190031709A1
公开(公告)日：2019-01-31
申请号：US16071925
申请日：2017-02-02
发明人： Jie CHEN , Yan CHEN , Ira B. DICKER , Richard A. HARTZ , Nicholas A. MEANWELL , Beata NOWICKA-SANS , Alicia REGUEIRO-REN , Sing-Yuen SIT , Ny SIN , Jacob SWIDORSKI , Brian Lee VENABLES
CPC分类号： C07J53/002 , A61P31/18 , C07J63/008 , C12N9/506 , C12N2740/16222
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US20170334945A1
公开(公告)日：2017-11-23
申请号：US15521957
申请日：2015-11-12
发明人： Jie CHEN , Yan CHEN , Nicholas A. MEANWELL , Alicia REGUEIRO-REN , Sing-Yuen SIT , Jacob SWIDORSKI
IPC分类号： C07J63/00
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US20170305962A1
公开(公告)日：2017-10-26
申请号：US15523453
申请日：2015-11-12
发明人： Jie CHEN , Yan CHEN , Nicholas A. MEANWELL , Alicia REGUEIRO-REN , NY SIN , Sing-Yuen SIT
IPC分类号： C07J63/00
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US20190307776A1
公开(公告)日：2019-10-10
申请号：US16308016
申请日：2017-06-28
发明人： Jie CHEN , Yan CHEN , Alicia REGUEIRO-REN , Sing-Yuen SIT , Jacob SWIDORSKI
IPC分类号： A61K31/58 , A61K31/5365 , C07J71/00 , A61P31/18
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, aza-substituted triterpenoid compounds that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US20230295220A1
公开(公告)日：2023-09-21
申请号：US18083037
申请日：2022-12-16
发明人： Jie CHEN , Yan Chen , Ira B. Dicker , Richard A. Hartz , Nicholas A. Meanwell , Beata Nowicka-Sans , Alicia Regueiro-ren , Sing-Yeun Sit , Ny Sin , Jacob Swidorski , Brian Lee Venables
CPC分类号： C07J53/002 , A61P31/18 , C07J63/008 , C12N9/506 , C12N2740/16222
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I:
These compounds are useful for the treatment of HIV and AIDS.-
公开(公告)号：US20210323997A1
公开(公告)日：2021-10-21
申请号：US17342941
申请日：2021-06-09
发明人： Jie CHEN , Yan Chen , Ira B. Dicker , Richard A. Hartz , Nicholas A. Meanwell , Beata Nowicka-Sans , Alicia Regueiro-Ren , Sing-Yuen Sit , Ny Sin , Jacob Swidorski , Brian Lee Venables
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US20190209550A1
公开(公告)日：2019-07-11
申请号：US16307632
申请日：2017-06-28
发明人： Jie CHEN , Nicholas A. MEANWELL , Alicia REGUEIRO-REN , Sing-Yuen SIT , Jacob SWIDORSKI , Yan CHEN
IPC分类号： A61K31/4725 , A61K31/5365 , A61K45/06 , A61K31/496 , C07D217/06 , A61K31/541 , A61K31/53 , C07D417/14 , C07D401/12 , C07D417/12 , C07D471/04 , C07D473/28 , A61K31/522 , C07D405/12 , C07D487/04 , C07D495/04 , C07D401/14 , C07D413/12 , C07D407/12 , C07D471/08 , C07D487/08 , C07D453/00 , A61K31/4748 , C07D491/056 , A61P31/18
CPC分类号： A61K31/4725 , A61K31/4748 , A61K31/496 , A61K31/522 , A61K31/53 , A61K31/5365 , A61K31/541 , A61K45/06 , A61P31/18 , C07D217/06 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D409/14 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D453/00 , C07D471/04 , C07D471/08 , C07D473/28 , C07D487/04 , C07D487/08 , C07D491/056 , C07D495/04
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, azadecaline derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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