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23 条记录 (耗时 0.033 秒)

    Process for assembling two surfaces or one surface with a molecule of interest
    6.
    发明申请
    Process for assembling two surfaces or one surface with a molecule of interest 有权
    将两个表面或一个表面与感兴趣的分子组装的方法

    公开(公告)号：US20090286308A1

    公开(公告)日：2009-11-19

    申请号：US12385269

    申请日：2009-04-02

    申请人： Thomas Berthelot ,  Guy Deniau ,  Vincent Huc ,  Xuan Tuan Le ,  Fabien Nekelson ,  Sébastien Roussell ,  Pascal Viel

    发明人： Thomas Berthelot ,  Guy Deniau ,  Vincent Huc ,  Xuan Tuan Le ,  Fabien Nekelson ,  Sébastien Roussell ,  Pascal Viel

    IPC分类号： C12M1/00 ,  B32B37/00 ,  B32B37/12 ,  C09C1/44 ,  G01N33/48

    CPC分类号： C09J5/02 ,  G01N33/54353 ,  G01N2035/00158 ,  Y10T156/10

    摘要： The present invention relates to a process for assembling at least one zone of a first surface with at least one zone of a second surface or with a molecule of interest, comprising a step that consists in placing the said zone of the said first surface in contact with the said zone of the said second surface or with the said molecule of interest, the said zone of the said first surface bearing at least one radical and/or ionic species. The present invention also relates to a solid support whose surface bears at least one zone with at least one radical and/or ionic species, with at least one adhesion primer, or with at least one adhesion primer precursor, and to its various uses.

    摘要翻译： 本发明涉及一种将第一表面的至少一个区域与第二表面的至少一个区域或感兴趣的分子组装的方法，包括将所述第一表面的所述区域放置在接触中的步骤 与所述第二表面的所述区域或所述感兴趣的分子，所述第一表面的所述区域具有至少一个自由基和/或离子物质。 本发明还涉及一种固体支持物，其表面具有至少一个具有至少一个自由基和/或离子物质的区域，至少一个粘附底漆，或至少一个粘合底漆前体，以及其各种用途。

    Fluorescent cyclic peptides, preparation method thereof and use of these peptides for measuring the enzymatic activity of a protease enzyme
    9.
    发明授权
    Fluorescent cyclic peptides, preparation method thereof and use of these peptides for measuring the enzymatic activity of a protease enzyme 有权
    荧光环肽，其制备方法和这些肽用于测量蛋白酶的酶活性的用途

    公开(公告)号：US09139862B2

    公开(公告)日：2015-09-22

    申请号：US12737082

    申请日：2009-06-10

    申请人： Thomas Berthelot ,  Gérard Deleris

    发明人： Thomas Berthelot ,  Gérard Deleris

    IPC分类号： C07K7/50 ,  C12Q1/37 ,  C07K7/64

    CPC分类号： C12Q1/37 ,  C07K7/64 ,  G01N2333/95 ,  G01N2333/96494

    摘要： The invention pertains to a cyclic peptide comprising the following sequence: -S1-X1-S2-X2- wherein S1 is a first target peptide sequence of a protease enzyme E1, S2 is a second target peptide sequence of a protease enzyme E2, S1 and S2 possibly being the same or different, said first peptide sequence S1 and said second peptide sequence S2 comprising 4 to 14 amino acids, E1 and E2 possibly corresponding to the same protease enzyme or to two different protease enzymes, X1 is a probe carrying a fluorescent donor group and X2 is a probe carrying a fluorescent or non-fluorescent acceptor group. Application of these peptides to determination of the activity of protease enzymes.

    摘要翻译： 本发明涉及包含以下序列的环肽：-S1-X1-S2-X2-，其中S1是蛋白酶E1的第一个靶肽序列，S2是蛋白酶E2的第二个靶肽序列，S1和 S2可能相同或不同，所述第一肽序列S1和包含4至14个氨基酸的第二肽序列S2，E1和E2可能对应于相同的蛋白酶或两种不同的蛋白酶，X1是携带荧光 供体组，X2是携带荧光或非荧光受体组的探针。 应用这些肽来测定蛋白酶的活性。

    Biosensor and Method of Manufacturing Such a Biosensor
    10.
    发明申请
    Biosensor and Method of Manufacturing Such a Biosensor 有权
    生物传感器和制造这种生物传感器的方法

    公开(公告)号：US20130327649A1

    公开(公告)日：2013-12-12

    申请号：US14000957

    申请日：2012-02-14

    申请人： Jérôme Polesel Maris ,  Thomas Berthelot

    发明人： Jérôme Polesel Maris ,  Thomas Berthelot

    IPC分类号： G01N27/327

    CPC分类号： G01N27/327 ,  B82Y15/00 ,  B82Y40/00 ,  G01N29/022 ,  G01N29/036 ,  G01N2291/0255 ,  G01N2291/0257 ,  G01N2291/0427

    摘要： A method of manufacturing a biosensor having a microbeam linked to a support, at least one electrode a biological molecule A grafted onto the microbeam in a different zone from the zone where the electrode is embedded, and a mechanoelectrical transducer for converting variations of the mechanical properties of the microbeam into an electrical signal, when the biological molecule A is placed in contact with a biological molecule B to be detected and/or quantified. The method includes: formation of an electrode on fluoropolymer material sheet, passivation of the electrode(s), creation of the form of the biosensor in the sheet of polymer material and separation of this form from the sheet, functionalization either of a prefunctionalized zone or of a zone of the microbeam, this zone being different from the zone wherein the electrode is embedded, and grafting of a biological molecule A onto the functionalized zone.

    摘要翻译： 一种制造具有与载体连接的微束的生物传感器的方法，至少一个电极，在与嵌入电极的区域不同的区域中接枝到微束上的生物分子A和用于转换机械性能变化的机械电传感器 当将生物分子A与待检测和/或定量的生物分子B接触时，将微束束转化为电信号。 该方法包括：在含氟聚合物材料片上形成电极，使电极钝化，在聚合物材料片中形成生物传感器的形式并将该形式与片材分离，将功能化前的功能化区域 的微波束的区域，该区域不同于电极被嵌入的区域，并且将生物分子A接枝到官能化区域上。