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    Delivery of plant growth regulators
    4.
    发明授权
    Delivery of plant growth regulators 失效
    植物生长调节剂的交付

    公开(公告)号：US4762549A

    公开(公告)日：1988-08-09

    申请号：US484027

    申请日：1983-04-11

    申请人： Vithal J. Rajadhyaksha

    发明人： Vithal J. Rajadhyaksha

    IPC分类号： A01N25/02 ,  A01N43/36 ,  A01N43/40 ,  A01N43/46 ,  A01N57/20 ,  A61F5/41 ,  A61K47/22 ,  C05F11/10

    CPC分类号： C05F11/10 ,  A01N25/02 ,  A01N43/36 ,  A01N43/40 ,  A01N43/46 ,  A01N57/20 ,  A61K47/22 ,  A61F2005/415

    摘要： The disclosure describes compositions and methods for improved delivery of plant growth regulators comprising contacting a plant with a composition comprising an effective amount of a plant growth regulator and an effective delivery enhancing amount of compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group having 1-4 carbon atoms, m is 3-7, n is 0-17 and R is --CH.sub.3, ##STR2## where R" is H or halogen, with the proviso that if m is 3 and R is CH.sub.3, then n is 5-17.

    摘要翻译： 本公开描述了用于改进植物生长调节剂递送的组合物和方法，其包括使植物与包含有效量的植物生长调节剂和有效递送量的具有结构式其中R'是H的化合物或 具有1-4个碳原子的低级烷基，m为3-7，n为0-17，R为-CH 3，其中R“为H或卤素，条件是如果m为3，R 是CH3，那么n是5-17。

    Penetration enhancers
    9.
    发明授权
    Penetration enhancers 失效
    渗透增强剂

    公开(公告)号：US5162315A

    公开(公告)日：1992-11-10

    申请号：US348387

    申请日：1989-05-08

    申请人： Vithal J. Rajadhyaksha ,  Richard S. Graham

    发明人： Vithal J. Rajadhyaksha ,  Richard S. Graham

    IPC分类号： A61K47/18 ,  A61K47/22 ,  C07C233/18 ,  C07C233/36 ,  C07D295/13 ,  C07D295/185

    CPC分类号： C07D295/185 ,  A61K47/18 ,  A61K47/22 ,  A61K9/0014 ,  C07C233/18 ,  C07C233/36 ,  C07D295/13

    摘要： Pharmaceutical compositions for enhancing absorption of a topically administered formulation through dermal or mucosal membrane, for local or systemic application, comprising one or more agents of formula I: ##STR1## where: R is a saturated or unsaturated, straight or branched, cyclic or acyclic hydrocarbon group with from 1 to 19 carbon atoms or an alkoxyalkyl group; n is 2-20; X is selected from H, OR.sub.2 or NR.sub.2 R.sub.3 ; wherein R.sub.1, R.sub.2 and R.sub.3 are independently selected from H, alkyl, haloalkyl, acyl, carbalkoxy, carbalkoxyalkyl, hydroyalkyl, acyloxyalkyl, alkoxyalkyl, aminoalkyl- and acylaminoalkyl; i) with the proviso that when n is 2, X is OR.sub.2 and R.sub.2 is H, then R.sub.1 is not hydroxyalkyl, specifically, 2-hydroxyethyl; and ii) with the proviso that when n is 2 and X is NR.sub.2 R.sub.3, then R.sub.1 and R.sub.2 may combine to form a heterocyclic ring and R.sub.3 is not acyl; and iii) with the proviso that when X is NR.sub.2 R.sub.3, then R.sub.2 and R.sub.3 may combine to form a heterocyclic ring; iv) with the proviso that when R is an alkoxyalkyl group then X may be hydrogen and when X is not hydrogen, and v) with the proviso that when X is H, R is not alkyl and R.sub.1 is not H and alkyl then R.sub.1 and X may combine to form heterocyclic ring and methods of using the same are disclosed.

    摘要翻译： 包含一种或多种式I的试剂，其中：R是饱和或不饱和的直链或支链，环状或非环状的药物组合物，用于通过皮肤或粘膜增强对局部施用的制剂的吸收， 具有1至19个碳原子的烃基或烷氧基烷基; n为2-20; X选自H，OR2或NR2R3; 其中R 1，R 2和R 3独立地选自H，烷基，卤代烷基，酰基，烷氧基，烷氧基烷基，烷氧基烷基，酰氧基烷基，烷氧基烷基，氨基烷基和酰基氨基烷基。 i），条件是当n为2时，X为OR2，R2为H，则R1不为羟烷基，具体为2-羟乙基; 和ii）条件是当n是2且X是NR 2 R 3时，则R 1和R 2可以结合形成杂环，并且R 3不是酰基; 和iii）条件是当X是NR 2 R 3时，则R 2和R 3可以结合形成杂环; iv）条件是当R是烷氧基烷基时，X可以是氢，当X不是氢时，v），条件是当X是H时，R不是烷基，R 1不是H，烷基然后是R1和 X可以结合形成杂环，并且公开使用该杂环的方法。

    Compositions and method comprising heterocyclic compounds containing two heteroatoms as membrane penetration enhancers
    10.
    发明授权
    Compositions and method comprising heterocyclic compounds containing two heteroatoms as membrane penetration enhancers 失效
    包含含有两个杂原子的杂环化合物作为膜渗透增强剂的组合物和方法

    公开(公告)号：US5030629A

    公开(公告)日：1991-07-09

    申请号：US393584

    申请日：1989-08-11

    申请人： Vithal J. Rajadhyaksha

    发明人： Vithal J. Rajadhyaksha

    IPC分类号： A61K9/00 ,  A61K47/22

    CPC分类号： A61K47/22 ,  A61K9/0014 ,  Y10S514/946 ,  Y10S514/947

    摘要： A method and compositions for enhancing absorption of topically administered physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for local or systemic use, comprising a therapeutically effective amount of a pharmaceutically active agent and a non-toxic, effective amount of penetration enhancing agent of the formula I: ##STR1## wherein R is a saturated or unsaturated, straight or branched, cyclic or acyclic hydrocarbon group with from 1 to 19 carbon atoms, alkoxyalkyl, haloalkyl, specifically trifluoromethyl, alkoxy, amino, alkylamino and acylamino; R' and R" are hydrogen, alkyl, trifluoromethyl, alkoxyalkyl, aminoalkyl, alkyl- and acylaminoalkyl, carboxy, carbalkoxy, hydroxyalkyl or lower alkyl ester thereof; X is O or NR.sub.1 wherein R.sub.1 is hydrogen, alkyl, alkenyl, alkoxyalkyl, carbalkoxyalkyl, aminoalkyl, alkyl- and acylaminoalkyl, hydroxyalkyl or hydroxyalkyloxyalkyl and lower alkyl ester thereof; and n is 2 or 3 are disclosed.