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    N-[(Benzofuran-2-yl)(phenyl)methyl]-alkylene diamines useful in treating arrhythmic, histaminic and tussive conditions
    9.
    发明授权
    N-[(Benzofuran-2-yl)(phenyl)methyl]-alkylene diamines useful in treating arrhythmic, histaminic and tussive conditions 失效
    N - [（苯并呋喃-2-基）（苯基）甲基] - 亚烷基二胺可用于治疗心律失常，组织和咳嗽状况

    公开(公告)号：US4485112A

    公开(公告)日：1984-11-27

    申请号：US468869

    申请日：1983-02-22

    申请人： Vittorio Pestellini ,  Mario Ghelardoni ,  Carlo Alberto Maggi ,  Gabrio Roncucci ,  Alberto Meli

    发明人： Vittorio Pestellini ,  Mario Ghelardoni ,  Carlo Alberto Maggi ,  Gabrio Roncucci ,  Alberto Meli

    IPC分类号： A61K31/34 ,  A61K31/343 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P3/06 ,  A61P9/06 ,  A61P21/02 ,  A61P25/02 ,  A61P43/00 ,  C07D307/80 ,  C07D307/81 ,  C07D307/86 ,  C07D307/92 ,  C07D405/12

    CPC分类号： C07D307/92 ,  C07D307/80 ,  C07D307/81 ,  C07D307/86

    摘要： A 2-substituted benzofuran derivative of general formula I or II ##STR1## in which R.sub.1 and R.sub.2, can be the same or different, and are a hydrogen atom, a halogen atom, an alkyl group containing 1 to 4 carbon atoms, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH.sub.2, NH-alkyl, N(alkyl).sub.2, NH(CO-alkyl), NH(CO-aryl) or NO.sub.2 group, or R.sub.1 and R.sub.2 can together form a ring of 5-8 carbon atoms; R.sub.3 is a hydrogen atom, an alkyl group containing 1 to 4 carbon atoms or an aryl group; R.sub.4 is a hydrogen atom, an alkyl group, an aryl or an arylalkyl group, R.sub.5 is a hydroxyl group, an alkoxy group, an OCO-aryl an OCO-alkyl, OCONH-alkyl or OCONH-aryl group, ##STR2## where n is a number between 1 and 4, R.sub.7 is a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, and R.sub.8 and R.sub.9, which can be the same or different, represent a hydrogen atom, an alkyl group, an aryl group, an alkoyl group, arylalkoyl group or an aroyl group, or can together form a heterocyclic ring which can contain supplementary heteratoms, and R.sub.6 is a hydrogen or halogen atom, an alkyl group, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH.sub.2, NH-alkyl, N(alkyl).sub.2, NHCO-alkyl, NHCO-aryl or NO.sub.2 group. The compounds are useful for treating arrhythmic, histaminic and tussive conditions.

    摘要翻译： 通式I或II的2-取代的苯并呋喃衍生物其中R 1和R 2可以相同或不同，并且是氢原子，卤素原子，烷基 含有1至4个碳原子，芳基烷基，芳基，羟基，烷氧基或NH 2，NH-烷基，N（烷基）2，NH（CO-烷基），NH（CO-芳基） 或NO 2基团，或者R 1和R 2可以一起形成5-8个碳原子的环; R3是氢原子，含有1至4个碳原子的烷基或芳基; R4是氢原子，烷基，芳基或芳基烷基，R5是羟基，烷氧基，OCO-芳基，OCO-烷基，OCONH-烷基或OCONH-芳基，IMA图像 >其中n是1至4之间的数，R 7是氢原子或含有1至4个碳原子的烷基，并且可以相同或不同的R 8和R 9表示氢原子，烷基， 芳基，芳酰基或芳酰基，或者可以一起形成可以含有补充杂原子的杂环，R6是氢或卤素原子，烷基，芳基烷基，芳基，羟基 基团，烷氧基或NH 2，NH-烷基，N（烷基）2，NHCO-烷基，NHCO-芳基或NO 2基团。 该化合物可用于治疗心律失常，组织和咳嗽状况。

    2-substituted benzofuran derivatives useful in treating cardiac arrhythmic, histaminic and tussive conditions
    10.
    发明授权
    2-substituted benzofuran derivatives useful in treating cardiac arrhythmic, histaminic and tussive conditions 失效
    2-取代的苯并呋喃衍生物，可用于治疗心律失常，组胺和咳嗽状况

    公开(公告)号：US4604392A

    公开(公告)日：1986-08-05

    申请号：US641606

    申请日：1984-08-17

    申请人： Vittorio Pestellini ,  Mario Ghelardoni ,  Carlo Alberto Maggi ,  Gabrio Roncucci ,  Alberto Meli

    发明人： Vittorio Pestellini ,  Mario Ghelardoni ,  Carlo Alberto Maggi ,  Gabrio Roncucci ,  Alberto Meli

    IPC分类号： A61K31/34 ,  A61K31/343 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P3/06 ,  A61P9/06 ,  A61P21/02 ,  A61P25/02 ,  A61P43/00 ,  C07D307/80 ,  C07D307/81 ,  C07D307/86 ,  C07D307/92 ,  C07D405/12 ,  C07D295/08

    CPC分类号： C07D307/92 ,  C07D307/80 ,  C07D307/81 ,  C07D307/86

    摘要： A 2-substituted benzofuran derivative of general formula I or II ##STR1## in which R.sub.1 and R.sub.2, can be the same or different, and are a hydrogen atom, a halogen atom, an alkyl group containing 1 to 4 carbon atoms, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH.sub.2, NH-alkyl, N(alkyl).sub.2, NH(CO-alkyl), NH(CO-aryl) or NO.sub.2 group, or R.sub.1 and R.sub.2 can together form a ring of 5-8 carbon atoms; R.sub.3 is a hydrogen atom, an alkyl group containing 1 to 4 carbon atoms or an aryl group; R.sub.4 is a hydrogen atom, an alkyl group, an aryl or an arylalkyl group, R.sub.5 is a hydroxyl group, an alkoxy group, an OCO-alkyl, an OCO-aryl, OCOHN-alkyl or OCONH-aryl group, ##STR2## where n is a number between 1 and 4, R.sub.7 is a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, and R.sub.8 and R.sub.9, which can be the same or different, represent a hydrogen atom, an alkyl group, an aryl group, an alkoyl group, arylalkoyl group or an aroyl group, or can together form a heterocyclic ring which can contain supplementary heteratoms, and R.sub.6 is a hydrogen or halogen atom, an alkyl group, an arylalkyl group, an aryl group, a hydroxyl group, an alkoxy group, or an NH.sub.2, NH-alkyl, (N(alkyl).sub.2, NHCO-alkyl, NHCO-aryl or NO.sub.2 group. The compounds are useful for treating cardiac arrhythmic, histaminic and tussive conditions.

    摘要翻译： 通式I或II的2-取代的苯并呋喃衍生物其中R 1和R 2可以相同或不同，并且是氢原子，卤素原子，烷基 含有1至4个碳原子，芳基烷基，芳基，羟基，烷氧基或NH 2，NH-烷基，N（烷基）2，NH（CO-烷基），NH（CO-芳基） 或NO 2基团，或者R 1和R 2可以一起形成5-8个碳原子的环; R3是氢原子，含有1至4个碳原子的烷基或芳基; R4是氢原子，烷基，芳基或芳烷基，R5是羟基，烷氧基，OCO-烷基，OCO-芳基，OCOHN-烷基或OCONH-芳基， TR 其中n是1-4之间的数，R7是氢原子或含有1至4个碳原子的烷基，R8和R9可以相同或不同，表示氢原子，烷基 基团，芳基，烷酰基，芳基烷酰基或芳酰基，或者可以一起形成可以含有补充杂原子的杂环，R6是氢或卤素原子，烷基，芳基烷基，芳基 ，羟基，烷氧基或NH 2，NH-烷基，（N（烷基）2，NHCO-烷基，NHCO-芳基或NO 2基团），该化合物可用于治疗心律失调，组胺和呕吐病症。