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1.发明授权Methods of treating autophagy-associated disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits 有权治疗自噬相关疾病和相关药物组合物，诊断，筛选技术和试剂盒的方法公开(公告)号：US09572820B2
公开(公告)日：2017-02-21
申请号：US14116581
申请日：2012-05-10
申请人： Vojo Deretic , Eliseo Castillo , Steven Bradfute , Larry A. Sklar
发明人： Vojo Deretic , Eliseo Castillo , Steven Bradfute , Larry A. Sklar
IPC分类号： A61K31/519 , A61K31/12 , A61K31/65 , C07K16/18 , G01N33/68 , A61K31/436 , A61K31/4365 , A61K31/4535 , A61K31/472 , A61K31/473 , A61K31/517 , A61K31/522 , A61K31/54 , A61K31/546 , A61K31/5685 , A61K31/585 , G01N33/569
CPC分类号： A61K31/436 , A61K31/12 , A61K31/136 , A61K31/4184 , A61K31/4365 , A61K31/4535 , A61K31/472 , A61K31/473 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/54 , A61K31/546 , A61K31/5685 , A61K31/585 , A61K31/65 , C07K16/18 , G01N33/56972 , G01N33/6893 , G01N2333/9015
摘要： The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.
摘要翻译： 本发明提供了治疗自噬介导的疾病和病症以及相关药物组合物，诊断，筛选技术和试剂盒的方法。 在一个实施方案中，本发明提供了一种通过评估LC3水平来确定受试者是否患有或有发展风险和自噬介导的疾病状态和/或状况的方法。
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2.发明申请METHODS OF TREATING AUTOPHAGY-ASSOCIATED DISORDERS AND RELATED PHARMACEUTICAL COMPOSITIONS, DIAGNOSTICS, SCREENING TECHNIQUES AND KITS 有权治疗自身相关疾病的方法和相关药物组合物，诊断，筛选技术和试剂盒公开(公告)号：US20140135296A1
公开(公告)日：2014-05-15
申请号：US14116581
申请日：2012-05-10
申请人： Vojo Deretic , Eliseo Castillo , Steven Bradfute , Larry A. Sklar
发明人： Vojo Deretic , Eliseo Castillo , Steven Bradfute , Larry A. Sklar
IPC分类号： A61K31/65 , A61K31/4535 , A61K31/4365 , A61K31/472 , A61K31/5685 , G01N33/569 , A61K31/517 , A61K31/546 , A61K31/436 , A61K31/522 , A61K31/54 , A61K31/585 , A61K31/473 , A61K31/519
CPC分类号： A61K31/436 , A61K31/12 , A61K31/136 , A61K31/4184 , A61K31/4365 , A61K31/4535 , A61K31/472 , A61K31/473 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/54 , A61K31/546 , A61K31/5685 , A61K31/585 , A61K31/65 , C07K16/18 , G01N33/56972 , G01N33/6893 , G01N2333/9015
摘要： The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.
摘要翻译： 本发明提供了治疗自噬介导的疾病和病症以及相关药物组合物，诊断，筛选技术和试剂盒的方法。 在一个实施方案中，本发明提供了一种通过评估LC3水平来确定受试者是否患有或有发展风险和自噬介导的疾病状态和/或状况的方法。
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公开(公告)号：US20130323243A1
公开(公告)日：2013-12-05
申请号：US13882041
申请日：2011-10-28
IPC分类号： A61K39/12
CPC分类号： G01N33/6854 , A61K39/12 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6056 , C07K14/005 , C07K2319/30 , C07K2319/43 , C12N2760/14122 , C12N2760/14134 , G01N33/56983 , G01N2333/08 , G01N2469/20 , G01N2800/26
摘要： This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.
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4.发明授权Fusion protein comprising the extracellular domain of a filovirus glycoprotein fused to an immunoglobulin heavy chain constant region 有权融合蛋白包含与免疫球蛋白重链恒定区融合的病毒糖蛋白的细胞外结构域公开(公告)号：US09347951B2
公开(公告)日：2016-05-24
申请号：US13882041
申请日：2011-10-28
IPC分类号： G01N33/68 , A61K39/12 , G01N33/569 , C07K14/005 , A61K39/00
CPC分类号： G01N33/6854 , A61K39/12 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6056 , C07K14/005 , C07K2319/30 , C07K2319/43 , C12N2760/14122 , C12N2760/14134 , G01N33/56983 , G01N2333/08 , G01N2469/20 , G01N2800/26
摘要： This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.
摘要翻译： 本发明提供包含病毒糖蛋白片段和免疫球蛋白多肽片段的融合蛋白。 融合蛋白可用于免疫原性组合物中，以防止人类和非人类动物中的诸如埃博拉病毒之类的病毒如伊洛韦病毒感染。 融合蛋白也可用于诊断测定法以检测病毒感染。
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