公开(公告)号：US6115633A

公开(公告)日：2000-09-05

申请号：US958199

申请日：1997-10-27

申请人： Volker Lang ,  Armin Bolz

发明人： Volker Lang ,  Armin Bolz

IPC分类号： A61N1/362 ,  A61N1/365

CPC分类号： A61N1/3622 ,  A61N1/36514 ,  A61N1/36571

摘要： An implantable stimulator for treating arrhythmic function disturbances of a heart, comprising; a stimulation electrode for transmitting stimulation pulses to the heart, a pulse generator that is connected to the stimulation electrode for generating the stimulation pulses, a control unit connected to the pulse generator for controlling the pulse emissions, a hemodynamic sensor for controlling the pulse emission as a function of the cardiac pumping performance, the hemodynamic sensor including; two measuring electrodes located in or in electrical contact with a blood vessel, for measuring the blood impedance dependent on the blood throughput, a signal generator that generates an AC voltage for generating a test signal for impedance measurement, an electrical measuring device connected to the twvo measuring electrodes for determining the blood throughput as a function of the measured electrical signal; and a blood throughput signal-analysis unit for recognizing an arrhythmic cardiac finction disturbance using the measured throughput quantity.

摘要翻译： 一种用于治疗心脏心律失常功能紊乱的植入式刺激器，包括： 用于将刺激脉冲发送到心脏的刺激电极，连接到用于产生刺激脉冲的刺激电极的脉冲发生器，连接到用于控制脉冲发射的脉冲发生器的控制单元，用于控制脉冲发射的血液动力学传感器， 心脏泵送性能的功能，血液动力学传感器包括; 位于血管中或与血管电接触的两个测量电极，用于测量取决于血液吞吐量的血液阻抗，产生用于产生用于阻抗测量的测试信号的AC电压的信号发生器，连接到twvo的电测量装置 用于确定作为所测量的电信号的函数的血液吞吐量的测量电极; 以及血液吞吐量信号分析单元，用于使用测量的吞吐量量来识别心律失常性心脏功能障碍。

公开(公告)号：US06553262B1

公开(公告)日：2003-04-22

申请号：US09399295

申请日：1999-09-17

申请人： Bernhard Lang ,  Johannes Neudecker ,  Armin Bolz

发明人： Bernhard Lang ,  Johannes Neudecker ,  Armin Bolz

IPC分类号： A61N1362

CPC分类号： A61B5/1112 ,  A61B5/0031 ,  G06F19/00 ,  Y10S128/903 ,  Y10S128/904

摘要： An arrangement for patient monitoring. The arrangement includes at least one body sensor to detect a physiological parameter as body signal data and at least one of a body signal processing unit connected to the body sensor for processing body signal data, and a therapy device designed to act on the patient. In addition, the arrangement includes a monitoring center having a signal field strength evaluation means, a mobile phone terminal designed to transmit the data from at least one of the body signal processing unit and the therapy device to the monitoring center and from the monitoring center to the therapy device, and a cellular mobile phone network. The mobile phone terminal is operable in the cellular mobile phone network. The arrangement further includes a base station coordinate storage unit for storage of coordinate data and a mobile phone exchange linked to the base station coordinate storage unit for the reception of position data of the mobile phone terminal. The signal field strength evaluation means is utilized for evaluating signal field strength data reflecting the distance of the mobile phone terminal from at least one base station together with coordinate data of at least one active base station of the mobile phone network in order to determine the whereabouts of the patient.

摘要翻译： 病人监护安排。 该装置包括至少一个身体传感器，用于检测作为身体信号数据的生理参数，以及连接到身体传感器以用于处理身体信号数据的身体信号处理单元中的至少一个，以及设计成作用于患者的治疗装置。 另外，该装置包括具有信号场强评估装置的监视中心，被设计为将数据从身体信号处理单元和治疗装置中的至少一个发送到监视中心的移动电话终端，并且从监视中心到监视中心 治疗装置和蜂窝移动电话网络。 移动电话终端可在蜂窝移动电话网络中操作。 该装置还包括用于存储坐标数据的基站坐标存储单元和链接到基站坐标存储单元的用于接收移动电话终端的位置数据的移动电话交换机。 信号场强评估装置用于评估反映移动电话终端距离至少一个基站的距离的信号场强数据以及移动电话网络的至少一个活动基站的坐标数据，以便确定下落 的病人。

公开(公告)号：US5080668A

公开(公告)日：1992-01-14

申请号：US442790

申请日：1989-11-29

申请人： Armin Bolz ,  Max Schaldach

发明人： Armin Bolz ,  Max Schaldach

IPC分类号： A61F2/24 ,  A61L27/30 ,  A61L27/50

CPC分类号： A61L27/306 ,  A61F2/2403 ,  A61L27/50

摘要： A cardiac valve prosthesis includes a rotatably mounted, disc-shaped valve flap which is provided with two outwardly oriented, convex attachments disposed opposite one another at the points of intersection of a secant with the edge of the disc. The valve also includes an annular body having on its interior wall first recesses for receiving the convex attachments to thus form a bearing socket for the valve flap. At its interior wall, the annular body is provided with second recesses which communicate with the first recesses to form a passage for the convex attachments during insertion thereof into the first recesses.

摘要翻译： 心脏瓣膜假体包括可旋转地安装的盘形瓣瓣，该瓣瓣设置有两个向外定向的凸起附件，其在割线与盘边缘的交叉点处彼此相对设置。 该阀还包括环形体，其在其内壁上具有用于接收凸起附件的第一凹部，从而形成用于阀瓣的轴承座。 在其内壁处，环形体设置有第二凹部，第二凹部与第一凹部连通，以在凸出附件插入第一凹槽期间形成用于凸起附件的通道。

公开(公告)号：US5970986A

公开(公告)日：1999-10-26

申请号：US929787

申请日：1997-09-15

申请人： Armin Bolz ,  Max Schaldach

发明人： Armin Bolz ,  Max Schaldach

IPC分类号： A61B5/00 ,  A61B5/05 ,  A61B5/053 ,  A61N5/00

CPC分类号： A61B5/053 ,  A61B5/0002 ,  A61B5/413 ,  A61B2560/0219

摘要： An apparatus for rejection diagnostics after organ transplantations is provided withan extracorporal base station with a high frequency transmitter and receiver unit, anda telemetric rejection sensor implantable in a patient's body, comprisinga high frequency receiver unit for receiving high frequency signals from the base station,a rectifier and decoder unit for converting the high frequency signals received into a supply voltage and control records for the rejection sensor,an energy storage for storing the supply voltage,a control unit for controlling the measuring processes within the apparatus,a sensor arrangement controlled by the control unit and to be brought into contact with the organ to be monitored and having measuring electrodes for measuring rejection-specific variables,an encoder unit for converting the measured variables into corresponding data signals, as well asa high frequency emitter unit for transmitting the data signals produced by the encoder unit to the extracorporal base station.

摘要翻译： 器官移植后用于排斥诊断的装置提供有具有高频发射器和接收器单元的外部基站和可植入患者体内的遥测抑制传感器，包括用于从基站接收高频信号的高频接收器单元 用于将接收的高频信号转换为电源电压的整流器和解码器单元，用于抑制传感器的控制记录，用于存储电源电压的能量存储器，用于控制设备内的测量过程的控制单元，控制的传感器装置 通过控制单元与要监视的器官接触并具有用于测量拒绝特定变量的测量电极，用于将测量的变量转换成相应的数据信号的编码器单元以及用于发送的高频发射器单元 由编码器单元产生的数据信号 机构外基地台。

公开(公告)号：US5571158A

公开(公告)日：1996-11-05

申请号：US193042

申请日：1994-06-23

申请人： Armin Bolz ,  Max Schaldach

发明人： Armin Bolz ,  Max Schaldach

IPC分类号： A61N1/05 ,  A61N1/04

CPC分类号： A61N1/05

摘要： A stimulation electrode having a porous surface coating whose active surface area is significantly greater than the surface area defined by the geometric shape of the electrode, wherein the surface coating comprises an inert material, i.e. a material having no or only a very slight oxidation tendency, wherein the material of the surface coating is formed from an inert element, an inert chemical compound and/or an inert alloy, and the active surface area, by virtue of its fractal-like geometry, is greater by a factor of at least one thousand than the surface area defined by the basic geometric shape of the electrode.

摘要翻译： PCT No.PCT / DE92 / 00658 Sec。 371日期1994年6月23日 102（e）日期1994年6月23日PCT提交1992年8月6日PCT公布。 出版物WO93 / 02739 日期：1993年2月18日一种具有多孔表面涂层的刺激电极，其活性表面积显着大于由电极的几何形状限定的表面积，其中表面涂层包括惰性材料，即不含或只有 非常轻微的氧化趋势，其中表面涂层的材料由惰性元素，惰性化合物和/或惰性合金形成，并且由于其分形几何形状，活性表面积大于一个因子 比由电极的基本几何形状限定的表面积至少一千。

公开(公告)号：US06463325B1

公开(公告)日：2002-10-08

申请号：US09464674

申请日：1999-12-15

申请人： Armin Bolz

发明人： Armin Bolz

IPC分类号： A61N018

CPC分类号： A61N1/368 ,  A61N1/36585

摘要： A self-calibrating rate-adaptive cardiac pacemaker is provided. The pacemaker comprising a first measuring and processing device for detecting a first, predominantly sympathetically influenced physiological parameter and for obtaining a rate control parameter, which has a control input for controlling the functional dependency of the rate control parameter on the first physiological parameter, in particular a response factor and/or an upper limit rate; and a stimulator unit for producing and outputting stimulation pulses at a stimulation rate which is determined by the rate control parameter, having a second measuring and processing device for detecting and evaluating a second, predominantly vagally influenced physiological parameter and for outputting a calibration signal which is dependent on the evaluation result, to the control input of the first measuring and processing device.

摘要翻译： 提供自校准速率自适应心脏起搏器。 该起搏器包括用于检测第一主要受交感影响的生理参数并用于获得速率控制参数的第一测量和处理装置，所述速率控制参数具有用于控制速率控制参数对第一生理参数的功能依赖性的控制输入，特别是 响应因子和/或上限速率; 以及刺激器单元，用于以由速率控制参数确定的刺激速率产生和输出刺激脉冲，具有用于检测和评估第二主要是迷失性影响的生理参数的第二测量和处理装置，并且用于输出校准信号， 取决于评估结果，到第一测量和处理装置的控制输入。

公开(公告)号：US06287332B1

公开(公告)日：2001-09-11

申请号：US09339927

申请日：1999-06-25

申请人： Armin Bolz ,  Thomas Popp

发明人： Armin Bolz ,  Thomas Popp

IPC分类号： A61F202

CPC分类号： A61F2/82 ,  A61F2210/0004 ,  A61L31/022 ,  A61L31/088 ,  A61L31/148

摘要： An implantable, bioresorbable vessel wall support, in particular a coronary stent, comprises a combination of metal materials which dissolves in the human body without any harmful effects on the person that wears the implant. The combination of metal materials can be an alloy or a local galvanic element.

摘要翻译： 可植入的生物可再吸收的血管壁支撑物，特别是冠状动脉支架，包括溶解在人体内的金属材料的组合，而不会对佩戴植入物的人造成任何有害影响。 金属材料的组合可以是合金或局部电流元件。

公开(公告)号：US5609611A

公开(公告)日：1997-03-11

申请号：US403723

申请日：1995-03-17

申请人： Armin Bolz ,  Max Schaldach

发明人： Armin Bolz ,  Max Schaldach

IPC分类号： A61N1/05 ,  A61N1/37 ,  A61N1/36

CPC分类号： A61N1/3706 ,  A61N1/0565

摘要： A cardiac pacemaker system is provided which includes a stimulation electrode adapted for being anchored in the heart. An output capacitor is coupled to the stimulation electrode. A first circuit coupled to the output capacitor generates stimulation pulses. A second circuit coupled to the output capacitor generates an autoshort pulse following each stimulation pulse to reduce a residual charge of the output capacitor for eliminating an after potential following a stimulation pulse by the stimulation electrode. A third circuit coupled to the output capacitor acquires an evoked pulse of the heart from an electrical signal picked up by the stimulation electrode. The stimulation electrode includes a porous surface coating made of an inert material and has an active surface that is substantially larger than a surface of the basic geometric form of the stimulation electrode. The second circuit includes circuit means for changing the time duration of the autoshort pulses as a function of the acquisition of the evoked pulses, with the time duration of the autoshort pulses being limited to 70 ms.

摘要翻译： PCT No.PCT / DE93 / 00887 Sec。 371日期1995年3月17日 102（e）1995年3月17日PCT PCT 1993年9月16日PCT公布。 公开号WO94 / 06508 日期1994年3月31日提供了一种心脏起搏器系统，其包括适于锚定在心脏中的刺激电极。 输出电容器耦合到刺激电极。 耦合到输出电容器的第一电路产生刺激脉冲。 耦合到输出电容器的第二电路在每个刺激脉冲之后产生自动转换脉冲，以减少输出电容器的剩余电荷，以消除刺激电极在刺激脉冲之后的后置电位。 耦合到输出电容器的第三电路从由刺激电极拾取的电信号获取心脏的诱发脉冲。 刺激电极包括由惰性材料制成的多孔表面涂层，并且具有基本上大于刺激电极的基本几何形状的表面的活性表面。 第二电路包括电路装置，用于根据获取的诱发脉冲改变自动更新脉冲的持续时间，自动更新脉冲的持续时间被限制为70ms。

公开(公告)号：US5871511A

公开(公告)日：1999-02-16

申请号：US929085

申请日：1997-09-15

申请人： Armin Bolz ,  Klaus Bartels ,  Erhard Flach ,  Rainer Hintsche ,  Manfred Paeschke

发明人： Armin Bolz ,  Klaus Bartels ,  Erhard Flach ,  Rainer Hintsche ,  Manfred Paeschke

IPC分类号： A61N1/362 ,  A61N1/365

CPC分类号： A61N1/3622

摘要： An implantable apparatus for the early diagnosis of tachycardia in the heart is provided witha microelectrode array, which is in contact with the cardiac muscle tissue, for detecting stimulus conduction potentials in the cardiac muscle tissue,a measuring device, which is in connection with the microelectrode array, for determining the refractory time of the cardiac muscle cells in the monitored cardiac region,a measuring device, which is in connection with the microelectrode array, for determining the stimulus conduction velocity in the monitored cardiac muscle region,a computing device for determining the product value of the refractory time and the stimulus conduction velocity,a comparator for comparing the product value with a tachycardia threshold, any falling short of the tachycardia threshold signaling a condition of the heart in risk of tachycardia,a stimulation arrangement for generating antitachycardia stimulation upon detection of a condition of risk of tachycardia in particular via the microelectrode array, anda control unit for controlling the measuring and evaluation processes within the apparatus.

摘要翻译： 用于早期诊断心脏中心动过速的可植入装置设置有与心肌组织接触的微电极阵列，用于检测心肌组织中的刺激传导电位，测量装置与 微电极阵列，用于确定监测的心脏区域中的心肌细胞的难治时间，与微电极阵列相关的测量装置，用于确定所监测的心肌区域中的刺激传导速度;计算装置，用于确定 难治时间和刺激传导速度的乘积值，用于将产品值与心动过速阈值进行比较的比较器，任何低于心动过速阈值的下降信号，表示心脏在心动过速风险中的状况，用于产生抗心动过速刺激的刺激装置 在检测到p的心动过速的风险的情况下 通过微电极阵列关联，以及用于控制装置内的测量和评估过程的控制单元。

公开(公告)号：US5849206A

公开(公告)日：1998-12-15

申请号：US794375

申请日：1997-02-04

申请人： Michael Amon ,  Armin Bolz

发明人： Michael Amon ,  Armin Bolz

IPC分类号： A61F2/00 ,  A61F2/82 ,  A61L27/30 ,  A61L31/08 ,  A61L33/02 ,  C23C16/02 ,  C23C16/32 ,  H01L21/308

CPC分类号： A61F2/82 ,  A61L27/306 ,  A61L31/088 ,  A61L33/027 ,  C23C16/0245 ,  C23C16/0272 ,  C23C16/325 ,  A61F2/0077 ,  A61F2240/001 ,  A61F2310/00742

摘要： A method of producing a biocompatible prosthesis based on a substrate made essentially of metal or ceramic. The substrate is placed into a reactor chamber of a cathodic vapor deposition arrangement and the chamber is evacuated to a predetermined pressure. A predetermined, negative bias voltage is then applied to the substrate and the substrate is surface treated by adding an etching gas to the reactor chamber, at a predetermined, first flow rate and coupling in a high frequency power with a first, predetermined power density for ionic etching for a first, predetermined period of time. The surface treated substrate is separated from the negative bias voltage and a semiconductor cover layer is chemical vapor-phase deposited on the substrate by adding to the reactor chamber a multi-component mixture of process gases containing a semiconductor element in bound form at a second, predetermined flow rate and coupling-in of HF power with a predetermined, second power density, for a second, predetermined time period.

摘要翻译： 一种生产基于由金属或陶瓷制成的基底的生物相容性假体的方法。 将衬底放置在阴极气相沉积装置的反应室中，并将室抽真空至预定压力。 然后将预定的负偏置电压施加到衬底，并且通过以预定的第一流量向反应器室中加入蚀刻气体并以高频功率与第一预定功率密度耦合来对衬底进行表面处理，用于 离子蚀刻第一预定时间段。 将经表面处理的衬底与负偏压分离，并且半导体覆盖层通过向反应器室中加入含有在第二个结合形式的半导体元件的工艺气体的多组分混合物而化学气相沉积在衬底上， 预定的流量和具有预定的第二功率密度的HF功率的耦合进入第二预定时间段。