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43 条记录 (耗时 0.021 秒)

    8-Phenyl-purines and pharmaceutical compositions containing same
    4.
    发明授权
    8-Phenyl-purines and pharmaceutical compositions containing same 失效
    8-苯基嘌呤和含有它们的药物组合物

    公开(公告)号：US4299834A

    公开(公告)日：1981-11-10

    申请号：US166709

    申请日：1980-07-08

    申请人： Volkhard Austel ,  Eberhard Kutter ,  Joachim Heider ,  Willi Diederen

    发明人： Volkhard Austel ,  Eberhard Kutter ,  Joachim Heider ,  Willi Diederen

    IPC分类号： A61K31/52 ,  A61P9/04 ,  C07D239/48 ,  C07D473/00

    CPC分类号： C07D239/48 ,  C07D473/00

    摘要： This invention is directed to 8-phenyl-purines of general formula ##STR1## wherein R.sub.1 is a hydrogen or halogen atom; an alkoxy group optionally substituted by alkylmercapto, alkylsulfinyl or alkylsulfonyl group; or an alkylmercapto, alkylsulfinyl or alkylsulfonyl group, whereby each alkyl moiety may contain from 1 to 3 carbon atoms, andR.sub.2 is an alkoxy group with from 1 to 3 carbon atoms, and their physiologically compatible acid addition salts. The compounds exhibit valuable pharmacological properties, particularly positive inotropic activity.

    摘要翻译： 本发明涉及通式为“IMAGE”的8-苯基嘌呤，其中R 1是氢或卤素原子; 任选被烷基巯基，烷基亚磺酰基或烷基磺酰基取代的烷氧基; 或烷基巯基，烷基亚磺酰基或烷基磺酰基，其中每个烷基部分可以含有1至3个碳原子，并且R 2是具有1至3个碳原子的烷氧基，以及它们的生理上相容的酸加成盐。 该化合物显示出有价值的药理学性质，特别是正性肌力活性。

    Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones
    8.
    发明授权
    Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones 失效
    苯并三唑基-4,5-二氢-3（2H） - 哒嗪酮

    公开(公告)号：US4616018A

    公开(公告)日：1986-10-07

    申请号：US749580

    申请日：1985-06-27

    申请人： Norbert Hauel ,  Volkhard Austel ,  Joachim Heider ,  Manfred Reiffen ,  Willi Diederen ,  Walter Haarman

    发明人： Norbert Hauel ,  Volkhard Austel ,  Joachim Heider ,  Manfred Reiffen ,  Willi Diederen ,  Walter Haarman

    IPC分类号： A61K31/50 ,  A61K31/501 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D249/18 ,  C07D401/14 ,  C07D403/04 ,  C07D403/02

    CPC分类号： C07D401/14 ,  C07D237/04 ,  C07D249/18 ,  C07D403/04 ,  Y10S514/822

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methylpyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; and,R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics, hypotensives and antithrombotics.

    摘要翻译： 其中R 1是氢的式IMAMA的化合物; 1至7个碳原子的烷基; 3至7个碳原子的环烷基; 其中取代基是吡啶基，甲基吡啶基，苯基，单 - ，二 - 或三取代的苯基，其中可以相同或不同的苯环上的取代基选自 由一个氨基，一个二甲基氨基，一至两个羟基，一至三个甲氧基和一至三个卤素组成的组; 2至4个碳原子的ω-单取代的烷基，其中取代基是羟基或二（1至3个碳原子的烷基）氨基; 苯基; 单卤代苯基; 未取代的或单取代的1至6个碳原子的直链或支链烷酰基，其中取代基是苯基，甲氧基苯基或3-7个碳原子的环烷基; 或未取代或单取代的苯基磺酰基，其中取代基是甲基或甲氧基; R2为氢或1〜3个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。 化合物及其盐可用作强心剂，低血糖剂和抗血栓药物。

    Pyridazinone-substituted benzimidazoles and salts
    9.
    发明授权
    Pyridazinone-substituted benzimidazoles and salts 失效
    哒嗪酮取代的苯并咪唑和盐

    公开(公告)号：US4361563A

    公开(公告)日：1982-11-30

    申请号：US259537

    申请日：1981-05-01

    申请人： Volkhard Austel ,  Joachim Heider ,  Wolfgang Eberlein ,  Willi Diederen ,  Walter Haarmann

    发明人： Volkhard Austel ,  Joachim Heider ,  Wolfgang Eberlein ,  Willi Diederen ,  Walter Haarmann

    IPC分类号： A61K31/50 ,  C07D235/18 ,  C07D237/04 ,  C07D403/04

    CPC分类号： C07D237/04 ,  A61K31/50 ,  C07D235/18 ,  Y10S514/822

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; trifluoromethyl; alkyl of 1 to 11 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; hydroxyl; alkoxy of 1 to 6 carbon atoms; mercapto; (alkyl of 1 to 6 carbon atoms)-mercapto; phenyl-(alkyl of 1 to 3 carbon atoms); phenyl; or mono-, di- or tri-substituted phenyl, where the substituents, which may be identical to or different from each other, are each halogen, alkyl of 1 to 4 carbon atoms, (alkyl of 1 to 6 carbon atoms)-sulfinyl, hydroxyl, alkoxy of 1 to 6 carbon atoms, mercapto or (alkyl of 1 to 6 carbon atoms)-mercapto;R.sub.2 is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or phenyl-(alkyl of 1 to 3 carbon atoms); andR.sub.3 is alkyl of 1 to 6 carbon atoms; optically active antipodes thereof; and non-toxic, pharmaceutically acceptable acid addition salts of said compounds or of said optically active antiposed. The compounds are useful as cardiotonics and antithrombotics.

    摘要翻译： 其中R 1是氢的式IMAMA的化合物; 三氟甲基 1至11个碳原子的烷基; 3至7个碳原子的环烷基; 羟; 1至6个碳原子的烷氧基; 巯基 （1-6个碳原子的烷基） - 巯基; 苯基 - （1至3个碳原子的烷基）; 苯基; 或单取代，二取代或三取代的苯基，其中可以相同或不同的取代基各自为卤素，具有1至4个碳原子的烷基，（1至6个碳原子的烷基） - 亚磺酰基 ，羟基，1至6个碳原子的烷氧基，巯基或（1至6个碳原子的烷基） - 巯基; R2是氢，1至6个碳原子的烷基，3至6个碳原子的环烷基或苯基 - （1至3个碳原子的烷基）; 且R 3为1至6个碳原子的烷基; 光学活性对映体; 和所述化合物或所述光学活性药物的无毒的药学上可接受的酸加成盐。 这些化合物可用作强心剂和抗血栓药物。