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1.发明授权公开(公告)号：US10792517B2
公开(公告)日：2020-10-06
申请号：US15823148
申请日：2017-11-27
摘要： The invention comprises a method and apparatus for determining state of a positively charged particle, such as a proton, for use in imaging a tumor of a patient prior to and/or concurrent with cancer therapy. The imaging system comprises: (1) a beam transport path of the positively charged particle sequentially passing through a patient, through a first time of flight detector, and, after traversing a pathlength, at least into a second time of flight detector and (2) a beam state determination system using elapsed time between detection at the first and second time of flight detectors and the pathlength to determine a residual beam energy, which, when compared to a known incident beam energy, is used in generation of an image of the tumor. An optional beam energy degrading element increases time differences between the time of flight detectors.
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公开(公告)号：US10751554B2
公开(公告)日：2020-08-25
申请号：US15901788
申请日：2018-02-21
申请人： Scott Penfold , Mark R. Amato , W. Davis Lee
发明人： Scott Penfold , Mark R. Amato , W. Davis Lee
摘要： The invention comprises a method and apparatus for using a turning magnet of an accelerator of a cancer therapy system, the accelerator comprising first magnet coils and second correction coils wound about a magnet core where: (1) at a first time, the second correction coils are used to correct a magnetic field, resultant from the first magnet coils, used to turn cations and (2) at a second time, after reversing polarity of the correction coils, the correction coils are used to turn anions and/or electrons, the cations and electrons used to treat a tumor of a patient positioned in a treatment position relative to a treatment beam from the accelerator during the first and second time periods.
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3.发明申请公开(公告)号：US20170128029A1
公开(公告)日：2017-05-11
申请号：US15412885
申请日：2017-01-23
申请人： Scott Penfold , Mark R. Amato , Edward Ivanov , Jillian Reno , Nick Ruebel , Stephen Siedge , Lauri Reichert , Kyle Schmanke , W. Davis Lee , James P. Bennett
发明人： Scott Penfold , Mark R. Amato , Edward Ivanov , Jillian Reno , Nick Ruebel , Stephen Siedge , Lauri Reichert , Kyle Schmanke , W. Davis Lee , James P. Bennett
CPC分类号： A61B6/4417 , A61B6/032 , A61B6/037 , A61B6/4258 , A61B6/4266 , A61B6/50 , A61B6/5205 , A61B6/5235 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1081 , A61N5/1082 , A61N2005/1051 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G01N23/04 , G01N2223/1006 , G01T1/2018 , G21K1/08 , G21K5/04
摘要： The invention comprises an apparatus and method of use thereof for using a single patient position during, optionally simultaneous, X-ray imaging and positively charged particle imaging, where imaging a tumor of a patient using X-rays and positively charged particles comprises the steps of: (1) generating an X-ray image using the X-rays directed from an X-ray source, through the patient, and to an X-ray detector, (2) generating a positively charged particle image: (a) using the positively charged particles directed from an exit nozzle, through the patient, through the X-ray detector, and to a scintillator, the scintillator emitting photons when struck by the positively charged particles and (b) generating the positively charged particle image of the tumor using a photon detector configured to detect the emitted photons, where the X-ray detector maintains a position between said the nozzle and the scintillator during the step of generating a positively charged particle image.
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公开(公告)号：US20180185673A1
公开(公告)日：2018-07-05
申请号：US15907076
申请日：2018-02-27
申请人： W. Davis Lee , Mark R. Amato , Scott Penfold , Stephen L. Spotts
发明人： W. Davis Lee , Mark R. Amato , Scott Penfold , Stephen L. Spotts
CPC分类号： A61N5/1077 , A61B6/00 , A61B6/03 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1039 , A61N5/1044 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1082 , A61N2005/1051 , A61N2005/1052 , A61N2005/1054 , A61N2005/1061 , A61N2005/1074 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K1/087 , G21K1/093 , G21K5/04 , H01J35/14
摘要： The invention comprises a method and apparatus for imaging and/or treating a tumor of a patient using multiple ion types, such as a cations with one, two, or more mass-to-charge ratios and/or electrons, where the multiple ion types are accelerated, at separate times, using a single accelerator, and the multiple ion types are used to treat different depths into a tumor of a patient, where the patient is optionally maintained in a single treatment position relative to a patient positioning system during treatment.
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5.发明申请DYNAMIC ENERGY CONTROL OF A CHARGED PARTICLE IMAGING/TREATMENT APPARATUS AND METHOD OF USE THEREOF 审中-公开充电颗粒成像/处理设备的动态能量控制及其使用方法公开(公告)号：US20170043187A1
公开(公告)日：2017-02-16
申请号：US15334122
申请日：2016-10-25
申请人： W. Davis Lee , Mark R. Amato , Scott Penfold
发明人： W. Davis Lee , Mark R. Amato , Scott Penfold
IPC分类号： A61N5/10
CPC分类号： A61N5/1077 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1039 , A61N5/1044 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a beam adjustment method and apparatus used to perform energy adjustments on circulating charged particles in a synchrotron previously accelerated to a starting energy with a traditional accelerator of the synchrotron. The beam adjustment system uses a radio-frequency modulated potential difference applied along a longitudinal path of the circulating charged particles to accelerate or decelerate the circulating charged particles. Optionally, the beam adjustment system phase shifts the applied radio-frequency field to accelerate or decelerate the circulating charged particles while tightening spatial distribution of a grouped bunch of the circulating charged particles. Optionally, the beam adjustment system simultaneously radially focuses the circulating charged particles using two or more gaps with focusing and/or defocusing edges. The beam adjustment system facilitates treating multiple layers or depths of the tumor without hysteresis and/or between the repeating slow steps of reloading the synchrotron.
摘要翻译： 本发明包括一种光束调节方法和装置，用于对先前加速到同步加速器的传统加速器的起始能量的同步加速器中的循环带电粒子进行能量调节。 光束调节系统使用沿着循环带电粒子的纵向路径施加的射频调制电位差来加速或减速循环的带电粒子。 可选地，光束调节系统相位移动所施加的射频场，以加速或减速循环的带电粒子，同时收紧分组的循环带电粒子的空间分布。 可选地，光束调节系统同时使用具有聚焦和/或散焦边缘的两个或多个间隙同时使循环的带电粒子聚焦。 束调节系统有助于治疗肿瘤的多个层或深度，而不会滞后和/或重新加载同步加速器的重复慢步骤之间。
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公开(公告)号：US20180200539A1
公开(公告)日：2018-07-19
申请号：US15919090
申请日：2018-03-12
申请人： Mark R. Amato , Scott Penfold , W. Davis Lee
发明人： Mark R. Amato , Scott Penfold , W. Davis Lee
CPC分类号： A61N5/1077 , A61B6/00 , A61B6/03 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1039 , A61N5/1044 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1071 , A61N5/1082 , A61N2005/1051 , A61N2005/1052 , A61N2005/1054 , A61N2005/1061 , A61N2005/1074 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K1/087 , G21K1/093 , G21K5/04 , H01J35/14
摘要： The invention comprises a method and apparatus for treating a tumor of a patient, comprising the steps of: (1) using a first treatment beam comprising electrons in a cancer therapy system used to treat the tumor, the electrons passing along a beam transport path from a synchrotron, through a beam transport system, through an exit nozzle, and toward the tumor and (2) using a second treatment beam to treat the tumor, the second treatment beam both generated using the synchrotron and penetrating into the tumor, where the second treatment beam comprises at least one of: (1) cations and (2) secondary X-rays emitted resultant from energy transfer from the electrons, where the cations are optionally used to image the tumor of the patient.
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7.发明授权公开(公告)号：US09937362B2
公开(公告)日：2018-04-10
申请号：US15334122
申请日：2016-10-25
申请人： W. Davis Lee , Mark R. Amato , Scott Penfold
发明人： W. Davis Lee , Mark R. Amato , Scott Penfold
CPC分类号： A61N5/1077 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1039 , A61N5/1044 , A61N5/1067 , A61N5/1069 , A61N5/107 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a beam adjustment method and apparatus used to perform energy adjustments on circulating charged particles in a synchrotron previously accelerated to a starting energy with a traditional accelerator of the synchrotron. The beam adjustment system uses a radio-frequency modulated potential difference applied along a longitudinal path of the circulating charged particles to accelerate or decelerate the circulating charged particles. Optionally, the beam adjustment system phase shifts the applied radio-frequency field to accelerate or decelerate the circulating charged particles while tightening spatial distribution of a grouped bunch of the circulating charged particles. Optionally, the beam adjustment system simultaneously radially focuses the circulating charged particles using two or more gaps with focusing and/or defocusing edges. The beam adjustment system facilitates treating multiple layers or depths of the tumor without hysteresis and/or between the repeating slow steps of reloading the synchrotron.
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公开(公告)号：US09855444B2
公开(公告)日：2018-01-02
申请号：US15348625
申请日：2016-11-10
申请人： Scott Penfold , W. Davis Lee , Mark R. Amato
发明人： Scott Penfold , W. Davis Lee , Mark R. Amato
CPC分类号： A61N5/1067 , A61B6/032 , A61B6/4258 , A61B6/5205 , A61N5/1037 , A61N5/1044 , A61N5/1049 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a method and apparatus for probing a tumor of a patient using positively charged particles, comprising the steps of: (1) sequentially delivering sets of varied and known positively charged particles to a patient; (2) after transmission through the patient, sequentially detecting a residual energy of each of the sets of positively charged particles; and (3) determining a water equivalent thickness of a probed path of the patient using a plot of the detector response as a function of residual energy that is fit with a curve. The analyzer relates a half maximum of the fit curve, such as a Gaussian curve, to the water equivalent thickness of the sampled beam path. Repeated measurements as a function of incident angle and/or position of the incident charged particles allows generation of an image of the sample, such as a computed tomography image.
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公开(公告)号：US20180178040A1
公开(公告)日：2018-06-28
申请号：US15901788
申请日：2018-02-21
申请人： Scott Penfold , Mark R. Amato , W. Davis Lee
发明人： Scott Penfold , Mark R. Amato , W. Davis Lee
摘要： The invention comprises a method and apparatus for using a turning magnet of an accelerator of a cancer therapy system, the accelerator comprising first magnet coils and second correction coils wound about a magnet core where: (1) at a first time, the second correction coils are used to correct a magnetic field, resultant from the first magnet coils, used to turn cations and (2) at a second time, after reversing polarity of the correction coils, the correction coils are used to turn anions and/or electrons, the cations and electrons used to treat a tumor of a patient positioned in a treatment position relative to a treatment beam from the accelerator during the first and second time periods.
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10.发明申请公开(公告)号：US20180078790A1
公开(公告)日：2018-03-22
申请号：US15823148
申请日：2017-11-27
申请人： W. Davis Lee , Scott Penfold , Mark R. Amato , Lou Wainwright
发明人： W. Davis Lee , Scott Penfold , Mark R. Amato , Lou Wainwright
IPC分类号： A61N5/10
摘要： The invention comprises a method and apparatus for determining state of a positively charged particle, such as a proton, for use in imaging a tumor of a patient prior to and/or concurrent with cancer therapy. The imaging system comprises: (1) a beam transport path of the positively charged particle sequentially passing through a patient, through a first time of flight detector, and, after traversing a pathlength, at least into a second time of flight detector and (2) a beam state determination system configured to: use elapsed time between detection at the first and second time of flight detectors and the pathlength to determine a residual beam energy, which, when compared to a known incident beam energy, is used in generation of an image of the tumor. An optional beam energy degrading element increases time differences between the time of flight detectors.
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