-
公开(公告)号：US20140005595A1
公开(公告)日：2014-01-02
申请号：US14004738
申请日：2012-03-19
IPC分类号： A61M31/00
CPC分类号： A61M31/007 , A61K9/5036 , A61M37/0069
摘要： Devices and methods for delivering therapeutic agents use a movable sheath member to deliver a therapeutic agent with little or no shear stress. The delivery device may include an outer body being configured to move away from a distal end of the delivery device. The movable sheath member may have a first section and a second section opposing the first section, the second section being configured to hold the therapeutic agent. The movable sheath may be configured to deliver the therapeutic agent by increasing the first section by moving the outer body away from the distal end.
摘要翻译： 用于递送治疗剂的装置和方法使用可移动护套构件递送具有很小或没有剪切应力的治疗剂。 输送装置可以包括外体，其被配置为远离输送装置的远端移动。 可移动护套构件可以具有与第一部分相对的第一部分和第二部分，第二部分构造成保持治疗剂。 可移动护套可经配置以通过使外体远离远端移动来增加第一部分来递送治疗剂。
-
公开(公告)号：US08535291B1
公开(公告)日：2013-09-17
申请号：US13466041
申请日：2012-05-07
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2034/102 , G06F19/00
摘要： A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.
摘要翻译： 医生可以指定涉及递送治疗剂的过程的某些参数，同时留下其他参数。 治疗剂可以对与递送相关的生物力学力（或其他影响）敏感。 该过程可以涉及再生医学，例如使用导管将祖细胞或干细胞递送到患病心脏，由此在导管中的肆无忌惮的运输可能损害功效。 开放参数可以影响药剂的疗效，从而影响治疗效果。 基于计算机的系统可以应用诸如数据库之类的存储信息来缩小开放参数的可能值。 从缩小的可能性，优化程序可以确定开放参数的合适或优化的值。 确定的值可以管理治疗剂引起的生物力学力，从而促进功效和愈合。 优化的参数可以指导实践者在程序中。
-
公开(公告)号：US08147479B1
公开(公告)日：2012-04-03
申请号：US12460097
申请日：2009-07-14
IPC分类号： A61M31/00
CPC分类号： A61M5/16831 , A61M5/48 , A61M5/484 , A61M25/01 , G01F1/34 , G01F1/58 , G01F1/66 , G01F1/661 , G01F1/663 , G01F1/7086 , G01F15/001
摘要： A physician, nurse, or other healthcare practitioner can deliver a therapeutic agent to a patient in a manner that maintains effectiveness of the therapeutic agent, via monitoring and controlling shear, stress, or other potentially detrimental effect. A gauge, meter, or other monitoring device can provide an indication of shear (or other effect) that the therapeutic agent is experiencing during delivery. The monitoring device can provide information relevant to delivering the therapeutic agent in a manner that maintains effectiveness, thereby guiding the practitioner during delivery. For example, the monitoring device can display an estimate of shear based on sensing flow rate or pressure. The therapeutic agent can comprise one or more therapeutic cells, such as progenitor cells or stem cells, or some other healing substance delivered via a cardiac catheter to the patient's cardiovascular tissue, for example.
摘要翻译： 医师，护士或其他保健医生可以通过监测和控制剪切力，压力或其它潜在的不利影响，以维持治疗剂的有效性的方式向患者递送治疗剂。 仪表，仪表或其他监测装置可提供治疗剂在输送过程中经历的剪切（或其他影响）的指示。 监测装置可以以保持有效性的方式提供与递送治疗剂相关的信息，从而在分娩期间指导医师。 例如，监测装置可以基于感测流量或压力显示剪切的估计。 例如，治疗剂可以包含一种或多种治疗细胞，例如祖细胞或干细胞，或通过心脏导管递送至患者的心血管组织的一些其它愈合物质。
-
4.发明授权Method and system for mitigating effects of biomechanical forces on cell, particle and drug based therapies 有权减轻生物力学对细胞，颗粒和药物治疗效果的方法和系统公开(公告)号：US08197462B1
公开(公告)日：2012-06-12
申请号：US12454396
申请日：2009-05-18
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2034/102 , G06F19/00
摘要： A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.
摘要翻译： 医生可以指定涉及递送治疗剂的过程的某些参数，同时留下其他参数。 治疗剂可以对与递送相关的生物力学力（或其他影响）敏感。 该过程可以涉及再生医学，例如使用导管将祖细胞或干细胞递送到患病心脏，由此在导管中的肆无忌惮的运输可能损害功效。 开放参数可以影响药剂的疗效，从而影响治疗效果。 基于计算机的系统可以应用诸如数据库之类的存储信息来缩小开放参数的可能值。 从缩小的可能性，优化程序可以确定开放参数的合适或优化的值。 确定的值可以管理治疗剂引起的生物力学力，从而促进功效和愈合。 优化的参数可以指导实践者在程序中。
-
公开(公告)号：US20150050348A1
公开(公告)日：2015-02-19
申请号：US13969317
申请日：2013-08-16
CPC分类号： A61K35/12 , C12N2527/00
摘要： A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.
摘要翻译： 医生可以指定涉及递送治疗剂的过程的某些参数，同时留下其他参数。 治疗剂可以对与递送相关的生物力学力（或其他影响）敏感。 该过程可以涉及再生医学，例如使用导管将祖细胞或干细胞递送到患病心脏，由此在导管中的肆无忌惮的运输可能损害功效。 开放参数可以影响药剂的疗效，从而影响治疗效果。 基于计算机的系统可以应用诸如数据库之类的存储信息来缩小开放参数的可能值。 从缩小的可能性，优化程序可以确定开放参数的合适或优化的值。 确定的值可以管理治疗剂引起的生物力学力，从而促进功效和愈合。 优化的参数可以指导实践者在程序中。
-
公开(公告)号：US08152755B1
公开(公告)日：2012-04-10
申请号：US12731019
申请日：2010-03-24
CPC分类号： A61M25/00 , A61M5/178 , A61M25/0026 , A61M25/007 , A61M2206/20
摘要： A catheter for delivering a therapeutic agent to a target site of a human or animal subject can include a substantially flexible and biocompatible catheter body having a proximal end and a distal end. An eductor can be located at the distal end of the catheter body, and a first lumen within the catheter body for housing the therapeutic agent can be in fluid communication with the eductor. A second lumen, also in fluid communication with the first lumen, can extend from the proximal end of the catheter body towards the eductor and can have an output port at the distal end of the catheter body. The eductor can be operable to induce the therapeutic agent to flow from the first lumen out of the output port in response to fluid flowing through the second lumen.
摘要翻译： 用于将治疗剂递送到人或动物受试者的靶位点的导管可以包括具有近端和远端的基本上柔性且生物相容的导管主体。 喷射器可以位于导管主体的远端，并且用于容纳治疗剂的导管主体内的第一腔可以与喷射器流体连通。 也与第一腔流体连通的第二腔可以从导管主体的近端延伸到喷射器，并且可以在导管主体的远端具有输出端口。 喷射器可操作以响应于流体流过第二腔而致使治疗剂从第一腔流出输出端口。
-
公开(公告)号：US10054522B1
公开(公告)日：2018-08-21
申请号：US14999504
申请日：2016-05-16
CPC分类号： A61B10/0038
摘要： Systems, devices and methods are configured to prepare a specimen. A system may include a preparation device configured to mate with a specimen collection device. The preparation device may include an agitator member and a filter member. The filter member and the agitator member may be configured to move independently with respect to each other and the preparation platform member. The filter member may be configured to move linearly with respect to the preparation platform member and/or the agitator member, and the agitator member may be configured to move linearly and radially with respect to the preparation platform member and/or the agitator member. The system may also include a specimen collection device. The specimen may include but is not limited to fecal matter.
-
公开(公告)号：US08873966B1
公开(公告)日：2014-10-28
申请号：US12380826
申请日：2009-02-25
申请人： Michael L. Wach
发明人： Michael L. Wach
IPC分类号： H04B10/40
CPC分类号： H04B10/40
摘要： An optical communication device, such as a transceiver, can send outgoing information over an optical link and receive incoming information via the link. The link, for example an optical fiber, can simultaneously transmit outgoing light carrying outgoing information and incoming light carrying incoming information. The communication device can comprise a detector outputting electrical signals in response to receiving optical signals, effectively converting signals from the optical domain to the electrical domain. The detector can receive a mixture of the incoming and the outgoing light, thereby producing an electrical signal containing imprints of both the incoming data and the outgoing data. The communication device can process the electrical signal to differentiate between the incoming data and the outgoing data. Knowing the outgoing data, the optical communication device can subtract from the electrical signal the portion of the signal associated with the outgoing light, thereby revealing the incoming data.
摘要翻译： 诸如收发器的光通信设备可以通过光链路发送输出信息，并经由链路接收传入信息。 链路，例如光纤，可以同时发送携带传入信息的输出光和携带传入信息的入射光。 通信设备可以包括响应于接收光信号而输出电信号的检测器，有效地将来自光域的信号转换到电域。 检测器可以接收入射光和出射光的混合，从而产生包含输入数据和输出数据的印记的电信号。 通信设备可以处理电信号以区分输入数据和输出数据。 了解输出数据，光通信设备可以从电信号中减去与出射光相关联的信号的部分，从而揭示输入数据。
-
公开(公告)号：US08363992B1
公开(公告)日：2013-01-29
申请号：US13366351
申请日：2012-02-05
申请人： Michael L. Wach , Dwight Holter
发明人： Michael L. Wach , Dwight Holter
IPC分类号： G02B6/34 , C03B37/018 , C03C25/00
CPC分类号： G02B6/3881 , B33Y80/00 , G02B6/12007 , G02B6/29364 , G02B6/29367 , G02B6/29368 , G02B6/30 , G02B6/3636 , G02B6/3644 , G02B6/3652
摘要： A micro identification system supports facile optical assemblies and components. A segment of optical fiber can comprise an identifier formed via actinic radiation. The identifier can generate a laser interference pattern that can be read through a cylindrical surface of the optical fiber to determine a code. Modified optical fibers are those fibers that have been shaped or coated to an extent beyond the demands of normal communications optical fibers. In one example, modified fibers are no longer than about two feet in length. For another example, the modified fibers can have either a non-cylindrical end face, a non flat end face, an end face the plane of which is not perpendicular to the longitudinal axis of the waveguide, an end face coated with high density filter, or an identifier on or near an end face.
摘要翻译： 微型识别系统支持轻松的光学组件和组件。 一段光纤可以包括通过光化辐射形成的标识符。 标识符可以产生可以通过光纤的圆柱形表面读取以确定代码的激光干涉图案。 改进的光纤是已经被成形或涂覆的范围超过正常通信光纤的要求的那些光纤。 在一个实例中，改性纤维的长度不超过约2英尺。 另一个例子，改性纤维可以具有非圆柱形端面，非平坦端面，其平面不垂直于波导的纵向轴线的端面，涂覆有高密度滤光片的端面， 或在端面上或附近的标识符。
-
公开(公告)号：US08116624B1
公开(公告)日：2012-02-14
申请号：US12011562
申请日：2008-01-28
申请人： Michael L. Wach
发明人： Michael L. Wach
CPC分类号： H04B10/073 , G01M11/35 , H04B10/0795
摘要： Light escaping from an optical path, for example via Raman or Rayleigh scattering, can provide information about how light flows in the path or about the optical path. The path can be a waveguide, an optical channel, or a fiber that may be attached to or integrated with a substrate, for example in a passive or active planar lightguide/lightwave circuit, photonic integrated circuit, semiconductor laser, or optoelectronic element. The escaped light can be color-shifted with respect to the primary light flowing along the path. The escaped light can leave the path at an angle that facilitates detection. Processing or analyzing the scattered light, for example with support of a computing device, can help evaluate the path and/or assess a light intensity pattern thereof, for example to aid design, engineering, testing, qualification, troubleshooting, inspection, manufacturing, etc.
摘要翻译： 从光路中逸出的光，例如通过拉曼或瑞利散射，可以提供有关光在光路中或围绕光路流动的信息。 该路径可以是波导，光学通道或可附接到基板或与衬底集成的光纤，例如在无源或有源平面光导/光波电路，光子集成电路，半导体激光器或光电子元件中。 逃逸的光可以相对于沿着路径流动的主要光进行颜色偏移。 逃逸的光线可以以便于检测的角度离开路径。 例如在计算设备的支持下处理或分析散射光可以帮助评估路径和/或评估其光强度图案，例如帮助设计，工程，测试，鉴定，故障排除，检查，制造等。 。
-
-
-
-
-
-
-
-
-
搜索结果
44 条记录 (耗时 0.04 秒)