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公开(公告)号：US08535291B1
公开(公告)日：2013-09-17
申请号：US13466041
申请日：2012-05-07
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2034/102 , G06F19/00
摘要： A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.
摘要翻译： 医生可以指定涉及递送治疗剂的过程的某些参数，同时留下其他参数。 治疗剂可以对与递送相关的生物力学力（或其他影响）敏感。 该过程可以涉及再生医学，例如使用导管将祖细胞或干细胞递送到患病心脏，由此在导管中的肆无忌惮的运输可能损害功效。 开放参数可以影响药剂的疗效，从而影响治疗效果。 基于计算机的系统可以应用诸如数据库之类的存储信息来缩小开放参数的可能值。 从缩小的可能性，优化程序可以确定开放参数的合适或优化的值。 确定的值可以管理治疗剂引起的生物力学力，从而促进功效和愈合。 优化的参数可以指导实践者在程序中。
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公开(公告)号：US08152755B1
公开(公告)日：2012-04-10
申请号：US12731019
申请日：2010-03-24
CPC分类号： A61M25/00 , A61M5/178 , A61M25/0026 , A61M25/007 , A61M2206/20
摘要： A catheter for delivering a therapeutic agent to a target site of a human or animal subject can include a substantially flexible and biocompatible catheter body having a proximal end and a distal end. An eductor can be located at the distal end of the catheter body, and a first lumen within the catheter body for housing the therapeutic agent can be in fluid communication with the eductor. A second lumen, also in fluid communication with the first lumen, can extend from the proximal end of the catheter body towards the eductor and can have an output port at the distal end of the catheter body. The eductor can be operable to induce the therapeutic agent to flow from the first lumen out of the output port in response to fluid flowing through the second lumen.
摘要翻译： 用于将治疗剂递送到人或动物受试者的靶位点的导管可以包括具有近端和远端的基本上柔性且生物相容的导管主体。 喷射器可以位于导管主体的远端，并且用于容纳治疗剂的导管主体内的第一腔可以与喷射器流体连通。 也与第一腔流体连通的第二腔可以从导管主体的近端延伸到喷射器，并且可以在导管主体的远端具有输出端口。 喷射器可操作以响应于流体流过第二腔而致使治疗剂从第一腔流出输出端口。
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3.发明授权Method and system for mitigating effects of biomechanical forces on cell, particle and drug based therapies 有权减轻生物力学对细胞，颗粒和药物治疗效果的方法和系统公开(公告)号：US08197462B1
公开(公告)日：2012-06-12
申请号：US12454396
申请日：2009-05-18
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2034/102 , G06F19/00
摘要： A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.
摘要翻译： 医生可以指定涉及递送治疗剂的过程的某些参数，同时留下其他参数。 治疗剂可以对与递送相关的生物力学力（或其他影响）敏感。 该过程可以涉及再生医学，例如使用导管将祖细胞或干细胞递送到患病心脏，由此在导管中的肆无忌惮的运输可能损害功效。 开放参数可以影响药剂的疗效，从而影响治疗效果。 基于计算机的系统可以应用诸如数据库之类的存储信息来缩小开放参数的可能值。 从缩小的可能性，优化程序可以确定开放参数的合适或优化的值。 确定的值可以管理治疗剂引起的生物力学力，从而促进功效和愈合。 优化的参数可以指导实践者在程序中。
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公开(公告)号：US08147479B1
公开(公告)日：2012-04-03
申请号：US12460097
申请日：2009-07-14
IPC分类号： A61M31/00
CPC分类号： A61M5/16831 , A61M5/48 , A61M5/484 , A61M25/01 , G01F1/34 , G01F1/58 , G01F1/66 , G01F1/661 , G01F1/663 , G01F1/7086 , G01F15/001
摘要： A physician, nurse, or other healthcare practitioner can deliver a therapeutic agent to a patient in a manner that maintains effectiveness of the therapeutic agent, via monitoring and controlling shear, stress, or other potentially detrimental effect. A gauge, meter, or other monitoring device can provide an indication of shear (or other effect) that the therapeutic agent is experiencing during delivery. The monitoring device can provide information relevant to delivering the therapeutic agent in a manner that maintains effectiveness, thereby guiding the practitioner during delivery. For example, the monitoring device can display an estimate of shear based on sensing flow rate or pressure. The therapeutic agent can comprise one or more therapeutic cells, such as progenitor cells or stem cells, or some other healing substance delivered via a cardiac catheter to the patient's cardiovascular tissue, for example.
摘要翻译： 医师，护士或其他保健医生可以通过监测和控制剪切力，压力或其它潜在的不利影响，以维持治疗剂的有效性的方式向患者递送治疗剂。 仪表，仪表或其他监测装置可提供治疗剂在输送过程中经历的剪切（或其他影响）的指示。 监测装置可以以保持有效性的方式提供与递送治疗剂相关的信息，从而在分娩期间指导医师。 例如，监测装置可以基于感测流量或压力显示剪切的估计。 例如，治疗剂可以包含一种或多种治疗细胞，例如祖细胞或干细胞，或通过心脏导管递送至患者的心血管组织的一些其它愈合物质。
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公开(公告)号：US20150050348A1
公开(公告)日：2015-02-19
申请号：US13969317
申请日：2013-08-16
CPC分类号： A61K35/12 , C12N2527/00
摘要： A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.
摘要翻译： 医生可以指定涉及递送治疗剂的过程的某些参数，同时留下其他参数。 治疗剂可以对与递送相关的生物力学力（或其他影响）敏感。 该过程可以涉及再生医学，例如使用导管将祖细胞或干细胞递送到患病心脏，由此在导管中的肆无忌惮的运输可能损害功效。 开放参数可以影响药剂的疗效，从而影响治疗效果。 基于计算机的系统可以应用诸如数据库之类的存储信息来缩小开放参数的可能值。 从缩小的可能性，优化程序可以确定开放参数的合适或优化的值。 确定的值可以管理治疗剂引起的生物力学力，从而促进功效和愈合。 优化的参数可以指导实践者在程序中。
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公开(公告)号：US20140005595A1
公开(公告)日：2014-01-02
申请号：US14004738
申请日：2012-03-19
IPC分类号： A61M31/00
CPC分类号： A61M31/007 , A61K9/5036 , A61M37/0069
摘要： Devices and methods for delivering therapeutic agents use a movable sheath member to deliver a therapeutic agent with little or no shear stress. The delivery device may include an outer body being configured to move away from a distal end of the delivery device. The movable sheath member may have a first section and a second section opposing the first section, the second section being configured to hold the therapeutic agent. The movable sheath may be configured to deliver the therapeutic agent by increasing the first section by moving the outer body away from the distal end.
摘要翻译： 用于递送治疗剂的装置和方法使用可移动护套构件递送具有很小或没有剪切应力的治疗剂。 输送装置可以包括外体，其被配置为远离输送装置的远端移动。 可移动护套构件可以具有与第一部分相对的第一部分和第二部分，第二部分构造成保持治疗剂。 可移动护套可经配置以通过使外体远离远端移动来增加第一部分来递送治疗剂。
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公开(公告)号：US10054522B1
公开(公告)日：2018-08-21
申请号：US14999504
申请日：2016-05-16
CPC分类号： A61B10/0038
摘要： Systems, devices and methods are configured to prepare a specimen. A system may include a preparation device configured to mate with a specimen collection device. The preparation device may include an agitator member and a filter member. The filter member and the agitator member may be configured to move independently with respect to each other and the preparation platform member. The filter member may be configured to move linearly with respect to the preparation platform member and/or the agitator member, and the agitator member may be configured to move linearly and radially with respect to the preparation platform member and/or the agitator member. The system may also include a specimen collection device. The specimen may include but is not limited to fecal matter.
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8.发明授权公开(公告)号：US08871268B2
公开(公告)日：2014-10-28
申请号：US13580615
申请日：2011-02-23
申请人： David Safranski , Kenneth Gall , W. Robert Taylor , Daiana Weiss
发明人： David Safranski , Kenneth Gall , W. Robert Taylor , Daiana Weiss
IPC分类号： A61K9/14 , C08F120/18 , C08K3/00
CPC分类号： C08G63/91 , C08F2/48 , C08F222/1006 , C08F290/062 , C08F299/024 , C08K3/00 , C08K5/0025 , C08K5/101 , C08K5/17 , C08L2201/06 , C08L2203/02 , C08F220/18 , C08F220/14 , C08F2222/1013
摘要： Methods of manufacturing a three-dimensional, biodegradable, thermoset polymeric network composition having desirable degradation and mechanical properties, comprising a macromer component cross-linked with a monofunctional acrylate-containing component. The macromer component can comprise a diacrylate-containing component polymerized with an amine-containing component, wherein the molar ratio of the diacrylate-containing component to the amine-containing component is greater than or equal to 1.
摘要翻译： 制备具有所需降解和机械性能的三维，可生物降解的热固性聚合物网络组合物的方法，其包含与含单官能丙烯酸酯的组分交联的大分子单体组分。 大分子单体组分可以包含与含胺组分聚合的含二丙烯酸酯的组分，其中含二丙烯酸酯的组分与含胺组分的摩尔比大于或等于1。
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公开(公告)号：US08628753B2
公开(公告)日：2014-01-14
申请号：US12892379
申请日：2010-09-28
申请人： Niren Murthy , W. Robert Taylor , Kousik Kundu , Sarah F. Knight , Sungmun Lee
发明人： Niren Murthy , W. Robert Taylor , Kousik Kundu , Sarah F. Knight , Sungmun Lee
CPC分类号： A61K49/0021 , C09B11/24 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , G01N33/5091
摘要： Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes capable of detecting one or more reactive oxygen species are described herein. The reduced dyes exhibit little or no fluorescence due to the disrupted π conjugation. However, upon reaction with ROS, the reduced dyes are oxidized, regenerating the extended π conjugation and causing a substantial increase in fluorescence intensity. In many case, the oxidized dye is generally membrane impermeable. However, upon reduction, many of the reduced dyes are membrane permeable. Thus, reduced dyes can accumulate in cells and/or tissue to amplify the signal. Once inside the cell or tissue, the reduced dye is reoxidized upon reaction with ROS, and the oxidized dye again becomes membrane impermeable, trapping the dye within the cell. The reduced dyes can be used to image ROS, such as hydroxide radical and superoxide, in serum, cell cultures, tissue explants, and in vivo.
摘要翻译： 本文描述了能够检测一种或多种活性氧的还原染料，例如氢氰酸，氘代菁和/或其它氘代染料。 还原的染料表现出很少的或没有荧光，由于破坏的π共轭。 然而，当与ROS反应时，还原的染料被氧化，再生延长的π共轭并引起荧光强度的显着增加。 在许多情况下，氧化染料通常是不透膜的。 然而，在还原时，许多还原染料是可透膜的。 因此，还原染料可以积聚在细胞和/或组织中以放大信号。 一旦在细胞或组织内部，还原的染料在与ROS反应时被再氧化，并且氧化的染料再次变成不透膜的，将染料捕获在细胞内。 还原染料可用于在血清，细胞培养物，组织外植体和体内成像ROS，例如氢氧根和超氧化物。
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10.发明授权Methods for preventing oxidative stress injury of a tissue by a Folate-TEMPOL conjugate 有权用于通过叶酸-TEMPOL缀合物预防组织的氧化应激损伤的方法公开(公告)号：US08815860B2
公开(公告)日：2014-08-26
申请号：US13497398
申请日：2010-09-21
申请人： W. Robert Taylor , Sarah F. Knight , Niren Murthy , Kousik Kundu
发明人： W. Robert Taylor , Sarah F. Knight , Niren Murthy , Kousik Kundu
IPC分类号： C07D401/10 , C07D475/08 , A61K31/519 , A61K31/445
CPC分类号： A61K31/4985 , A61K47/551
摘要： The present disclosure is generally related to methods of preventing oxidative stress injury induced by renal ischemia-reperfusion by a Folate-TEMPOL conjugate.
摘要翻译： 本公开通常涉及通过叶酸-TEMPOL缀合物预防肾缺血再灌注诱导的氧化应激损伤的方法。
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