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公开(公告)号：US09056850B2
公开(公告)日：2015-06-16
申请号：US12578934
申请日：2009-10-14
申请人： Walter Ferdinand Maria Filliers , Rudy Laurent Maria Broeckx , Patrick Hubert J. Nieste , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Christopher Teleha
发明人： Walter Ferdinand Maria Filliers , Rudy Laurent Maria Broeckx , Patrick Hubert J. Nieste , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Christopher Teleha
IPC分类号： C07D409/04 , C07D333/12 , C07D409/10
CPC分类号： C07D333/12 , C07D409/10 , C07H7/04 , C07H13/04
摘要： The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
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公开(公告)号：US08153682B2
公开(公告)日：2012-04-10
申请号：US12175740
申请日：2008-07-18
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： C07D419/12 , C07D417/12 , C07D413/12 , C07D409/04 , C07D409/12 , C07D333/66 , A61K31/5377 , A61K31/496 , A61K31/4535 , A61K31/433 , A61K31/4245 , A61K31/422 , A61K31/4196 , A61K31/4192 , A61K31/4178 , A61K31/4025 , A61K31/381
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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公开(公告)号：US20120184510A1
公开(公告)日：2012-07-19
申请号：US13006810
申请日：2011-01-14
申请人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
发明人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
IPC分类号： A61K31/675 , C07F9/28 , C07F9/02 , C07D333/50 , A61K31/67
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/6541 , C07F9/65517 , C07F9/655345 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US20090264474A1
公开(公告)日：2009-10-22
申请号：US12175740
申请日：2008-07-18
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/4439 , C07D333/66 , A61K31/381 , C07D417/12 , C07D409/12 , A61K31/4196 , A61K31/427 , C07D401/14
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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公开(公告)号：US20120190674A1
公开(公告)日：2012-07-26
申请号：US13407251
申请日：2012-02-28
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/381 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61P9/12 , A61P25/00 , A61P29/00 , A61P25/22 , A61P25/24 , A61P9/00 , C07D333/66 , A61K31/541
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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公开(公告)号：US20080027029A1
公开(公告)日：2008-01-31
申请号：US11746318
申请日：2007-05-09
申请人： Raymond Colburn , Scott Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark Youngman
发明人： Raymond Colburn , Scott Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark Youngman
IPC分类号： A61K31/67 , A61K31/665 , A61K31/675 , A61P25/00 , A61P29/00 , A61P9/00 , A61P9/12 , C07D495/00 , C07F9/572 , C07F9/655 , C07F9/6553
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/65517 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。
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7.发明授权Fluorinated pyridine N-oxide thrombin modulators and process for N-oxidation of nitrogen containing heteroaryls 有权氟化吡啶N-氧化物凝血酶调节剂和含氮杂芳基的N-氧化方法公开(公告)号：US07262210B2
公开(公告)日：2007-08-28
申请号：US11385056
申请日：2006-03-21
申请人： Kevin Kreutter , Tianbao Lu , Yu Kai Lee , Christopher Teleha , Mark Player , Xizhen Zhu
发明人： Kevin Kreutter , Tianbao Lu , Yu Kai Lee , Christopher Teleha , Mark Player , Xizhen Zhu
IPC分类号： A61K31/44 , C07D213/00
CPC分类号： C07D213/89 , C07D215/60 , C07D239/24 , C07D241/10
摘要： The present invention describes compounds of Formula I or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to thrombin activity in a mammal. The present invention also relates to a novel method of N-oxidation of nitrogen containing heteroaryls.
摘要翻译： 本发明描述了式I化合物或其药学上可接受的盐，用于预防或治疗与哺乳动物中凝血酶活性相关的疾病和病症。 本发明还涉及含氮杂芳基的N-氧化的新方法。
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公开(公告)号：US08629281B2
公开(公告)日：2014-01-14
申请号：US13006810
申请日：2011-01-14
申请人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
发明人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
IPC分类号： C07F9/28
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/6541 , C07F9/65517 , C07F9/655345 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US20070225282A1
公开(公告)日：2007-09-27
申请号：US11685544
申请日：2007-03-13
申请人： Mark Player , Tianbao Lu , Huaping Hu , Xizhen Zhu , Christopher Teleha , Kevin Kreutter
发明人： Mark Player , Tianbao Lu , Huaping Hu , Xizhen Zhu , Christopher Teleha , Kevin Kreutter
IPC分类号： A61K31/5377 , A61K31/4439 , C07D413/14
CPC分类号： C07D213/89 , C07D213/74 , C07D213/84 , C07D401/14 , C07D413/14
摘要： The present invention describes compounds of Formula I: wherein W, X, Y, Z, and Q are defined herein, or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to thrombin activity in a mammal.
摘要翻译： 本发明描述了式I的化合物：其中W，X，Y，Z和Q在本文中定义，或其药学上可接受的盐，用于预防或治疗与哺乳动物中凝血酶活性相关的疾病和病症。
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10.发明申请Fluorinated pyridine N-oxide thrombin modulators and process for N-oxidation of nitrogen containing heteroaryls 有权氟化吡啶N-氧化物凝血酶调节剂和含氮杂芳基的N-氧化方法公开(公告)号：US20060241148A1
公开(公告)日：2006-10-26
申请号：US11385056
申请日：2006-03-21
申请人： Kevin Kreutter , Tianbao Lu , Yu Lee , Christopher Teleha , Mark Player , Xizhen Zhu
发明人： Kevin Kreutter , Tianbao Lu , Yu Lee , Christopher Teleha , Mark Player , Xizhen Zhu
IPC分类号： A61K31/444 , C07D213/84 , C07D401/02
CPC分类号： C07D213/89 , C07D215/60 , C07D239/24 , C07D241/10
摘要： The present invention describes compounds of Formula I or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to thrombin activity in a mammal. The present invention also relates to a novel method of N-oxidation of nitrogen containing heteroaryls.
摘要翻译： 本发明描述了式I化合物或其药学上可接受的盐，用于预防或治疗与哺乳动物中凝血酶活性相关的疾病和病症。 本发明还涉及含氮杂芳基的N-氧化的新方法。
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