公开(公告)号：US11774415B2

公开(公告)日：2023-10-03

申请号：US17212329

申请日：2021-03-25

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Burnett ,  Rose Solow ,  David A. Simpson ,  Peter Osswald ,  John M. Auclair ,  Michael LeBeau

IPC: G01N30/28 ,  G01N30/02 ,  G01N30/32

CPC classification number: G01N30/28 ,  G01N2030/027 ,  G01N2030/326 ,  G01N2030/328

Abstract: Described is a metering pump that may be used to meter volumes of sample in a chromatography system. The metering pump has a modular configuration that allows for separation of a head pod from a drive assembly for easy serviceability. The head pod includes a pump head, cartridge housing, seal wash housing and plunger. The drive assembly can be implemented in an inline drive configuration. Alternatively, the drive assembly can be implemented in an offset drive configuration in which a stepper motor is displaced laterally from other drive assembly components but is coupled through a belt and pulley system.

公开(公告)号：US11162923B2

公开(公告)日：2021-11-02

申请号：US16512559

申请日：2019-07-16

Applicant: Waters Technologies Corporation

Inventor： David A. Simpson ,  Joshua A. Burnett ,  John M. Auclair

IPC: G01N30/16 ,  G01N30/18 ,  G01N30/02

Abstract: A twist-lock compliant needle including a housing component surrounding a needle holder holding a rigidly mounted needle, the housing component including a biasing element disposed therein, wherein the biasing element compresses as a needle tip of the needle contacts a surface is provided. An associated method is also provided.

公开(公告)号：US20200025722A1

公开(公告)日：2020-01-23

申请号：US16512559

申请日：2019-07-16

Applicant: Waters Technologies Corporation

Inventor： David A. Simpson ,  Joshua A. Burnett ,  John M. Auclair

IPC: G01N30/18

Abstract: A twist-lock compliant needle including a housing component surrounding a needle holder holding a rigidly mounted needle, the housing component including a biasing element disposed therein, wherein the biasing element compresses as a needle tip of the needle contacts a surface is provided. An associated method is also provided.

公开(公告)号：US20240201142A1

公开(公告)日：2024-06-20

申请号：US18586786

申请日：2024-02-26

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Burnett ,  Rose Solow ,  David A. Simpson ,  Marc E. Lemelin

IPC: G01N30/16 ,  G01N35/10

CPC classification number: G01N30/16 ,  G01N35/1079 ,  G01N35/1095 ,  G01N2035/1027

Abstract: A liquid chromatography sample manager includes a thermal chamber, a sample platter mounted in the thermal chamber, and a needle drive including a base having a shaft configured to rotate about a vertical axis, the base attachable to an interior of a sample manager of a liquid chromatography system. The needle drive further includes a needle assembly attached to the base, the needle assembly including a sample needle, and a drive system attached to the base, the drive system including a sample needle motor configured to impart vertical movement of the sample needle. The liquid chromatography sample manager further includes a sample delivery system configured to transfer a first sample from a first sample vial carrier located in the sample platter into a chromatographic flow stream.

公开(公告)号：US20240060939A1

公开(公告)日：2024-02-22

申请号：US18497302

申请日：2023-10-30

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Burnett ,  Rose Solow ,  David A. Simpson

IPC: G01N30/24 ,  G01N30/20 ,  G01N30/36

CPC classification number: G01N30/24 ,  G01N30/20 ,  G01N30/36 ,  G01N2030/027

Abstract: A method and a fluidic network for acquiring and injecting a chromatographic sample into a chromatography system flow include a metering pump module, a sample needle, a needle seal and an injection valve. The metering pump module includes a metering pump and a pressure transducer in serial fluidic communication. When the injection valve is in a first valve state, the injection valve is configured to fluidically terminate ports of the metering pump module. When the injection valve is in a second valve state, the injection valve is configured to fluidically couple a fluidic path that includes the metering pump module and sample needle into the system flow of a chromatography system without resulting in a substantial change in the pressure of the system flow.

公开(公告)号：US20250025882A1

公开(公告)日：2025-01-23

申请号：US18906390

申请日：2024-10-04

Applicant: Waters Technologies Corporation

Inventor： Rose Solow ,  David A. Simpson ,  Colin F. Fredette ,  Marc E. Lemelin ,  Joshua A. Burnett

IPC: G01N1/34 ,  G01N1/14 ,  B01L3/02 ,  G01N35/10

Abstract: Described herein are systems and methods used for washing needle assemblies with multiple needles.

公开(公告)号：US11913916B2

公开(公告)日：2024-02-27

申请号：US17203127

申请日：2021-03-16

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Burnett ,  Rose Solow ,  David A. Simpson ,  Marc E. Lemelin

IPC: G01N30/16 ,  G01N35/10

CPC classification number: G01N30/16 ,  G01N35/1079 ,  G01N35/1095 ,  G01N2035/1027

Abstract: A liquid chromatography sample manager includes a thermal chamber, a sample platter mounted in the thermal chamber, and a needle drive including a base having a shaft configured to rotate about a vertical axis, the base attachable to an interior of a sample manager of a liquid chromatography system. The needle drive further includes a needle assembly attached to the base, the needle assembly including a sample needle, and a drive system attached to the base, the drive system including a sample needle motor configured to impart vertical movement of the sample needle. The liquid chromatography sample manager further includes a sample delivery system configured to transfer a first sample from a first sample vial carrier located in the sample platter into a chromatographic flow stream.

公开(公告)号：US11835496B2

公开(公告)日：2023-12-05

申请号：US17126236

申请日：2020-12-18

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Burnett ,  Rose Solow ,  David A. Simpson

IPC: G01N30/24 ,  G01N30/20 ,  G01N30/36 ,  G01N30/02

CPC classification number: G01N30/24 ,  G01N30/20 ,  G01N30/36 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202

Abstract: A method and a fluidic network for acquiring and injecting a chromatographic sample into a chromatography system flow include a metering pump module, a sample needle, a needle seal and an injection valve. The metering pump module includes a metering pump and a pressure transducer in serial fluidic communication. When the injection valve is in a first valve state, the injection valve is configured to fluidically terminate ports of the metering pump module. When the injection valve is in a second valve state, the injection valve is configured to fluidically couple a fluidic path that includes the metering pump module and sample needle into the system flow of a chromatography system without resulting in a substantial change in the pressure of the system flow.

公开(公告)号：US20210190734A1

公开(公告)日：2021-06-24

申请号：US17126236

申请日：2020-12-18

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Burnett ,  Rose Solow ,  David A. Simpson

IPC: G01N30/20 ,  G01N30/36

Abstract: Described are a method and a fluidic network for acquiring and injecting a chromatographic sample into a chromatography system flow. The fluidic network includes a metering pump module, a sample needle, a needle seal and an injection valve. The metering pump module includes a metering pump and a pressure transducer in serial fluidic communication. When the injection valve is in a first valve state, the injection valve is configured to fluidically terminate ports of the metering pump module. When the injection valve is in a second valve state, the injection valve is configured to fluidically couple a fluidic path that includes the metering pump module and sample needle into the system flow of a chromatography system without resulting in a substantial change in the pressure of the system flow.

公开(公告)号：US20190383776A1

公开(公告)日：2019-12-19

申请号：US16438798

申请日：2019-06-12

Applicant: Waters Technologies Corporation

Inventor： David A. Simpson ,  Joshua A. Burnett ,  Marc E. Lemelin

IPC: G01N30/16

Abstract: A liquid chromatography sample organizer includes a first chamber, a plurality of stacked sample organizer shelves mounted within the first chamber each individually configured to store a sample-vial carrier including a sample, and a shelf magnet affixed to a surface of each of the plurality of stacked sample organizer shelves. A portion of the first chamber is configured to be located adjacent to, and open to, a sample manager configured to inject liquid chromatography samples into a chromatographic flow stream. Disclosed further is a liquid chromatography system having the sample organizer, a sample drawer, and a method of transferring samples between a sample manager and the sample organizer.