公开(公告)号：US09791423B2

公开(公告)日：2017-10-17

申请号：US14632073

申请日：2015-02-26

Applicant: Waters Technologies Corporation

Inventor： Theodore Dourdeville ,  Joshua A. Burnett ,  James Usowicz ,  Marc Lemelin ,  Lucas O. Tiziani

IPC: G01N30/80 ,  B01L3/02 ,  G01N30/02

CPC classification number: G01N30/80 ,  B01L3/0241 ,  B01L2300/0838 ,  B01L2300/165 ,  G01N2030/027

Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced.

公开(公告)号：US09446330B2

公开(公告)日：2016-09-20

申请号：US13892830

申请日：2013-05-13

Applicant: Waters Technologies Corporation

Inventor： Christopher C. Benevides ,  Robert Collamati ,  Bruce J. Compton ,  Theodore Dourdeville

IPC: B01D15/22 ,  G01N30/60 ,  G01N30/72 ,  G01N30/02 ,  G01N30/30

CPC classification number: B01D15/22 ,  G01N30/02 ,  G01N30/30 ,  G01N30/6091 ,  G01N30/7266

Abstract: A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection.

公开(公告)号：US20150247830A1

公开(公告)日：2015-09-03

申请号：US14632073

申请日：2015-02-26

Applicant: Waters Technologies Corporation

Inventor： Theodore Dourdeville ,  Joshua A. Burnett ,  James Usowicz ,  Marc Lemelin ,  Lucas O. Tiziani

IPC: G01N30/80

CPC classification number: G01N30/80 ,  B01L3/0241 ,  B01L2300/0838 ,  B01L2300/165 ,  G01N2030/027

Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced.

Abstract translation: 描述了用于馏分收集器的分配针。 分配针包括具有流体通道以进行色谱流的导管，限定流体通道的内壁，分配有色谱流的外表面和端面。 分配针还包括结合到端面的烃材料或氟碳材料的涂层。 该涂层还结合到邻近端面的外表面的至少一部分和与端面相邻的内壁的至少一部分。 涂层操作以减少从端面分配的可能保留在分配针的尖端处的液体的液滴体积。 因此，由于缺少液滴或额外的液滴而导致的收集部分的浓度变化减小。

公开(公告)号：US20130248700A1

公开(公告)日：2013-09-26

申请号：US13892830

申请日：2013-05-13

Applicant: Waters Technologies Corporation

Inventor： Christopher C. Benevides ,  Robert Collamati ,  Bruce J. Compton ,  Theodore Dourdeville

IPC: B01D15/22 ,  G01N30/02

CPC classification number: B01D15/22 ,  G01N30/02 ,  G01N30/30 ,  G01N30/6091 ,  G01N30/7266

Abstract: A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection.

Abstract translation: 高压液相色谱（HPLC）毛细管柱装置，用于处理具有容纳填充毛细管柱的盒的HPLC样品的系统和方法; 用于样品流体的至少一个到毛细管柱的入口连接; 以及用于样品流体的来自毛细管柱的至少一个出口连接。 出口连接能够容纳用于雾化样品流体的喷嘴或用于将样品流体从喷嘴塔输送到喷嘴的输送管。 入口连接使得能够通过设置在盒壳体内的电气连接向毛细管柱供应电力; 并且用于蒸发样品液体的气体从用于样品流体的毛细管柱通过盒壳体内的气体供给管线供应到至少一个出口连接。 可以通过热连接来控制样品液体的温度。