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公开(公告)号：US20150042089A1
公开(公告)日：2015-02-12
申请号：US14382850
申请日：2013-02-01
Applicant: Waters Technologies Corporation
Inventor： Kurt D. Joudrey , Sylvain Cormier , James Usowicz , Emily J. Berg , Christopher Seith
CPC classification number: F16L19/061 , G01N30/6026
Abstract: A fitting for coupling fluidic paths, such as high pressure fluidic paths in liquid chromatography systems, includes a compression nut, a tube assembly and a compression member. The compression nut has a threaded outer surface to engage a threaded bore of a receiving port and the tube assembly has an outer surface and an end face to contact a sealing surface of the receiving port. The compression member is pre-staked to the outer surface of the tube assembly at a predetermined distance from the end face and has a tapered surface to engage a surface of the receiving port. The predetermined distance permits the tube assembly to be inserted into the receiving port so that the end face makes contact with the sealing surface without the tapered surface engaging a surface of the receiving port and so that the threaded outer surface of the compression nut engages the threaded bore.
Abstract translation: 用于耦合流体路径（例如液相色谱系统中的高压流体路径）的配件包括压缩螺母，管组件和压缩构件。 压缩螺母具有螺纹外表面以接合接收端口的螺纹孔，并且管组件具有外表面和端面以接触接收端口的密封表面。 压缩构件预先固定在距离端面一预定距离的管组件的外表面上，并且具有锥形表面以接合接收端口的表面。 预定距离允许管组件插入到接收端口中，使得端面与密封表面接触，而锥形表面接合接收端口的表面，并且使得压缩螺母的螺纹外表面接合螺纹 孔。
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公开(公告)号：US20150246351A1
公开(公告)日：2015-09-03
申请号：US14632091
申请日：2015-02-26
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Burnett , James Usowicz , Marc Lemelin , Lucas O. Tiziani
CPC classification number: B01L3/0241 , B01D15/247 , B01L2300/0838 , B01L2300/161 , B05B1/00 , G01N30/04 , G01N30/80
Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic system flow. The dispensing needle also includes a needle tip that has a fluid channel and an endface. The fluid channel of the needle tip is disposed at a dispensing end of the conduit and has a cross-sectional area that is less than a cross-sectional area of the fluid channel of the conduit. The fluid channels are in communication and enable a liquid chromatography system flow at a first velocity in the conduit to be dispensed at the endface of the needle tip at a second velocity that is greater than the first velocity. Advantageously, any droplets that may form at the endface of the needle tip are reduced in volume and therefore concentration variations for collected fractions are reduced.
Abstract translation: 描述了用于馏分收集器的分配针。 分配针包括具有用于进行色谱系统流动的流体通道的导管。 分配针还包括具有流体通道和端面的针尖。 针尖的流体通道设置在导管的分配端，并且具有小于导管的流体通道的横截面面积的横截面积。 流体通道处于连通状态，使液相色谱系统以导管中的第一速度流动，以比第一速度大的第二速度在针尖的端面分配。 有利地，可以在针尖的端面处形成的任何液滴体积减小，因此收集的馏分的浓度变化减小。
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公开(公告)号：US20160131617A1
公开(公告)日：2016-05-12
申请号：US14929785
申请日：2015-11-02
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Burnett , James Usowicz , Marc Lemelin , Lucas O. Tiziani , Aaron Lebeau
CPC classification number: G01N30/32 , G01N30/78 , G01N30/80 , G01N2030/027 , G01N2030/324 , G01N2030/328
Abstract: Apparatus and method measure the flow rate of fluid for use in calibrating fraction collection in a chromatography system. An injector inserts a detectable substance into a flow of fluid. A first detector, disposed in a path of the flow of liquid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A second detector, disposed downstream from the first detector in the path of the flow of fluid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A computing system receives each signal produced by the first and second detectors upon detecting the substance in the flow of fluid, and computes a volumetric flow rate of the flow of fluid based on a time interval between the signals and a volume of the path between the first and second detectors.
Abstract translation: 仪器和方法测量用于校准色谱系统中馏分收集的流体流速。 注射器将可检测物质插入流体流中。 设置在与物质的液体流动的路径中的第一检测器响应于检测流体中的物质而产生信号。 在流体与物质流动的路径中的第一检测器下游设置的第二检测器响应于检测流体中的物质而产生信号。 计算系统在检测到流体中的物质时接收由第一和第二检测器产生的每个信号，并且基于信号之间的时间间隔和第二检测器之间的路径的体积来计算流体流的体积流量 第一和第二检测器。
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Patent Agency Ranking
公开(公告)号：US20150247830A1
公开(公告)日：2015-09-03
申请号：US14632073
申请日：2015-02-26
Applicant: Waters Technologies Corporation
Inventor： Theodore Dourdeville , Joshua A. Burnett , James Usowicz , Marc Lemelin , Lucas O. Tiziani
IPC: G01N30/80
CPC classification number: G01N30/80 , B01L3/0241 , B01L2300/0838 , B01L2300/165 , G01N2030/027
Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced.
Abstract translation: 描述了用于馏分收集器的分配针。 分配针包括具有流体通道以进行色谱流的导管，限定流体通道的内壁，分配有色谱流的外表面和端面。 分配针还包括结合到端面的烃材料或氟碳材料的涂层。 该涂层还结合到邻近端面的外表面的至少一部分和与端面相邻的内壁的至少一部分。 涂层操作以减少从端面分配的可能保留在分配针的尖端处的液体的液滴体积。 因此，由于缺少液滴或额外的液滴而导致的收集部分的浓度变化减小。
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公开(公告)号：US11185794B2
公开(公告)日：2021-11-30
申请号：US14632049
申请日：2015-02-26
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Burnett , James Usowicz , Marc Lemelin , Lucas O. Tiziani , John Lamoureux , Aaron Lebeau
Abstract: Described are a fraction collector and a method of fraction collection for a liquid chromatography system. The method includes diverting a liquid chromatography system flow from a waste channel to a collection tube at a start of a fraction collection window and collecting the system flow dispensed from the collection tube during the fraction collection window. At the end of the window, the system flow is diverted to the waste channel and a flow of a wash solvent is provided to the collection tube to dispense liquid remaining in the collection tube at the end of the window from the collection tube. The method can increase the amount of the collected fraction and can reduce or eliminate cross-contamination of a subsequently collected fraction. The method is useful for analytical scale applications where the collected fractions may have volumes defined by a limited number of drops dispensed from the collection tube.
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公开(公告)号：US10175209B2
公开(公告)日：2019-01-08
申请号：US14929785
申请日：2015-11-02
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Burnett , James Usowicz , Marc Lemelin , Lucas O. Tiziani , Aaron Lebeau
Abstract: Apparatus and method measure the flow rate of fluid for use in calibrating fraction collection in a chromatography system. An injector inserts a detectable substance into a flow of fluid. A first detector, disposed in a path of the flow of liquid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A second detector, disposed downstream from the first detector in the path of the flow of fluid with the substance, produces a signal in response to detecting the substance in the flow of fluid. A computing system receives each signal produced by the first and second detectors upon detecting the substance in the flow of fluid, and computes a volumetric flow rate of the flow of fluid based on a time interval between the signals and a volume of the path between the first and second detectors.
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公开(公告)号：US20150246296A1
公开(公告)日：2015-09-03
申请号：US14632049
申请日：2015-02-26
Applicant: Waters Technologies Corporation
Inventor： Joshua A. Burnett , James Usowicz , Marc Lemelin , Lucas O. Tiziani , John Lamoureux , Aaron Lebeau
CPC classification number: B01D15/10 , B01D15/247
Abstract: Described are a fraction collector and a method of fraction collection for a liquid chromatography system. The method includes diverting a liquid chromatography system flow from a waste channel to a collection tube at a start of a fraction collection window and collecting the system flow dispensed from the collection tube during the fraction collection window. At the end of the window, the system flow is diverted to the waste channel and a flow of a wash solvent is provided to the collection tube to dispense liquid remaining in the collection tube at the end of the window from the collection tube. The method can increase the amount of the collected fraction and can reduce or eliminate cross-contamination of a subsequently collected fraction. The method is useful for analytical scale applications where the collected fractions may have volumes defined by a limited number of drops dispensed from the collection tube.
Abstract translation: 描述了用于液相色谱系统的级分收集器和级分收集方法。 该方法包括将液相色谱系统流从废液通道转移到收集管，并在馏分收集窗口开始收集从收集管分配的系统流量。 在窗口的末端，系统流被转移到废物通道，并且向收集管提供洗涤溶剂的流动，以从收集管中分配残留在窗口末端处的收集管中的液体。 该方法可以增加收集的馏分的量并且可以减少或消除随后收集的馏分的交叉污染。 该方法对于分析量表应用是有用的，其中收集的级分可以具有由从收集管分配的有限数量的液滴定义的体积。
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公开(公告)号：US09791423B2
公开(公告)日：2017-10-17
申请号：US14632073
申请日：2015-02-26
Applicant: Waters Technologies Corporation
Inventor： Theodore Dourdeville , Joshua A. Burnett , James Usowicz , Marc Lemelin , Lucas O. Tiziani
CPC classification number: G01N30/80 , B01L3/0241 , B01L2300/0838 , B01L2300/165 , G01N2030/027
Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced.
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