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    Interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4
    1.
    发明授权
    Interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-3和4

    公开(公告)号：US06495519B1

    公开(公告)日：2002-12-17

    申请号：US09124934

    申请日：1998-07-28

    申请人： Wei Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    发明人： Wei Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC分类号： A61K3848

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed are human interleukin-1 &bgr; converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury.

    摘要翻译： 公开了人白细胞介素-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。

    Interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4
    2.
    发明授权
    Interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-3和4

    公开(公告)号：US06835555B1

    公开(公告)日：2004-12-28

    申请号：US09613508

    申请日：2000-07-10

    申请人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    发明人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC分类号： C12P2102

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed are human interleukin-1 &bgr; converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

    摘要翻译： 公开了人白细胞介素-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

    Antibodies to interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4
    3.
    发明授权
    Antibodies to interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-3和4的抗体

    公开(公告)号：US06733981B2

    公开(公告)日：2004-05-11

    申请号：US09895263

    申请日：2001-07-02

    申请人： Wei Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    发明人： Wei Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC分类号： C12P2108

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed are human interlude-1 &bgr; converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury.

    摘要翻译： 公开了人间插-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。

    Interleukin-1 Beta Converting Enzyme Like Apoptosis Protease-3 and 4
    5.
    发明申请
    Interleukin-1 Beta Converting Enzyme Like Apoptosis Protease-3 and 4 审中-公开
    白细胞介素-1β转化酶如细胞凋亡蛋白酶-3和4

    公开(公告)号：US20090142329A1

    公开(公告)日：2009-06-04

    申请号：US12197977

    申请日：2008-08-25

    申请人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    发明人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC分类号： A61K38/48 ,  C12N15/11 ,  C12N15/00 ,  C12N1/21 ,  A61K31/711 ,  C12Q1/37 ,  C12Q1/68 ,  C12P21/04 ,  C12N15/87 ,  C12N9/50

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed are human interleukin-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

    摘要翻译： 公开了人白细胞介素-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

    Immunoassay methods for detecting interleukin-1 β converting enzyme like apoptosis protease-3
    6.
    发明授权
    Immunoassay methods for detecting interleukin-1 β converting enzyme like apoptosis protease-3 失效
    用于检测白细胞介素-1β转换酶如凋亡蛋白酶-3的免疫测定方法

    公开(公告)号：US07416855B2

    公开(公告)日：2008-08-26

    申请号：US10801669

    申请日：2004-03-17

    申请人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    发明人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC分类号： G01N33/00 ,  G01N33/53 ,  C12N5/16

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed are human interleukin-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

    摘要翻译： 公开了人白细胞介素-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

    Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
    8.
    发明授权
    Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides 失效
    编码前列腺生长因子的多核苷酸和产生前列腺生长因子多肽的方法

    公开(公告)号：US06521227B1

    公开(公告)日：2003-02-18

    申请号：US09461418

    申请日：1999-12-18

    申请人： Peter L. Hudson ,  Craig A. Rosen ,  Wei Wu He

    发明人： Peter L. Hudson ,  Craig A. Rosen ,  Wei Wu He

    IPC分类号： A61K3942

    CPC分类号： C07K14/575 ,  A61K39/00 ,  C07K16/22

    摘要： The present invention relates to human PGF polypeptides, DNA (RNA) encoding such polypeptides, and antibodies specifically binding such polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques, and for producing antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using the polypeptide therapeutically for treating prostate cancer, promoting tissue regeneration, and facilitating wound healing. Further provided are methods of using such antibodies therapeutically to inhibit the action of PGF polypeptides and for the treatment of PGF-dependent tumors. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.

    摘要翻译： 本发明涉及人PGF多肽，编码这种多肽的DNA（RNA）和与这些多肽特异性结合的抗体。 还提供了通过重组技术产生这种多肽的方法，以及用于产生抗这种多肽的抗体和拮抗剂/抑制剂。 还提供了用于治疗前列腺癌，促进组织再生和促进伤口愈合的方法。 进一步提供的是使用这种抗体治疗性地抑制PGF多肽的作用和用于治疗PGF依赖性肿瘤的方法。 还提供了用于检测前列腺癌和良性前列腺增生的诊断测定法。

    Prostatic growth factor
    9.
    发明授权
    Prostatic growth factor 失效
    前列腺增生因子

    公开(公告)号：US07282351B2

    公开(公告)日：2007-10-16

    申请号：US10270377

    申请日：2002-10-15

    申请人： Peter L. Hudson ,  Craig A. Rosen ,  Wei-Wu He

    发明人： Peter L. Hudson ,  Craig A. Rosen ,  Wei-Wu He

    IPC分类号： C07H21/04 ,  C12N5/10 ,  C12N15/63 ,  C12P21/02

    CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K39/00 ,  C07K14/475 ,  C07K14/575 ,  Y10S530/854

    摘要： The present invention relates to human PGF polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques, and antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using such polypeptides therapeutically for treating prostate cancer, to promote tissue regeneration and to facilitate wound healing. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.

    摘要翻译： 本发明涉及人PGF多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法，以及针对这种多肽的抗体和拮抗剂/抑制剂。 还提供了使用这些多肽治疗性治疗前列腺癌，促进组织再生和促进伤口愈合的方法。 还提供了用于检测前列腺癌和良性前列腺增生的诊断测定法。