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    Interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4
    1.
    发明授权
    Interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-3和4

    公开(公告)号：US06495519B1

    公开(公告)日：2002-12-17

    申请号：US09124934

    申请日：1998-07-28

    申请人： Wei Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    发明人： Wei Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC分类号： A61K3848

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed are human interleukin-1 &bgr; converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury.

    摘要翻译： 公开了人白细胞介素-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。

    Interleukin-1 Beta Converting Enzyme Like Apoptosis Protease-3 and 4
    2.
    发明申请
    Interleukin-1 Beta Converting Enzyme Like Apoptosis Protease-3 and 4 审中-公开
    白细胞介素-1β转化酶如细胞凋亡蛋白酶-3和4

    公开(公告)号：US20090142329A1

    公开(公告)日：2009-06-04

    申请号：US12197977

    申请日：2008-08-25

    申请人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    发明人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC分类号： A61K38/48 ,  C12N15/11 ,  C12N15/00 ,  C12N1/21 ,  A61K31/711 ,  C12Q1/37 ,  C12Q1/68 ,  C12P21/04 ,  C12N15/87 ,  C12N9/50

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed are human interleukin-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

    摘要翻译： 公开了人白细胞介素-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

    Immunoassay methods for detecting interleukin-1 β converting enzyme like apoptosis protease-3
    3.
    发明授权
    Immunoassay methods for detecting interleukin-1 β converting enzyme like apoptosis protease-3 失效
    用于检测白细胞介素-1β转换酶如凋亡蛋白酶-3的免疫测定方法

    公开(公告)号：US07416855B2

    公开(公告)日：2008-08-26

    申请号：US10801669

    申请日：2004-03-17

    申请人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    发明人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC分类号： G01N33/00 ,  G01N33/53 ,  C12N5/16

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed are human interleukin-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

    摘要翻译： 公开了人白细胞介素-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

    Interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4
    4.
    发明授权
    Interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-3和4

    公开(公告)号：US06835555B1

    公开(公告)日：2004-12-28

    申请号：US09613508

    申请日：2000-07-10

    申请人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    发明人： Wei-Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC分类号： C12P2102

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed are human interleukin-1 &bgr; converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

    摘要翻译： 公开了人白细胞介素-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

    Antibodies to interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4
    5.
    发明授权
    Antibodies to interleukin-1 &bgr; converting enzyme like apoptosis protease-3 and 4 失效
    白细胞介素-1β转换酶如凋亡蛋白酶-3和4的抗体

    公开(公告)号：US06733981B2

    公开(公告)日：2004-05-11

    申请号：US09895263

    申请日：2001-07-02

    申请人： Wei Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    发明人： Wei Wu He ,  Craig A. Rosen ,  Peter L. Hudson ,  Gregg A. Hastings

    IPC分类号： C12P2108

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed are human interlude-1 &bgr; converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury.

    摘要翻译： 公开了人间插-1β转换酶如凋亡蛋白酶-3和4以及编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用多肽例如抗肿瘤剂和抗病毒剂的方法，以及抗这种多肽的抗体和拮抗剂，例如用于治疗阿尔茨海默病，帕金森病，类风湿性关节炎和头部损伤。

    Human vascular IBP-like growth factor
    10.
    发明授权
    Human vascular IBP-like growth factor 失效
    人血管IBP样生长因子

    公开(公告)号：US5747280A

    公开(公告)日：1998-05-05

    申请号：US464339

    申请日：1995-06-05

    申请人： Gregg A. Hastings ,  Craig A. Rosen

    发明人： Gregg A. Hastings ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/475 ,  C12N15/12

    CPC分类号： C07K14/65 ,  C07K14/475 ,  G01N33/6893 ,  G01N33/74 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026 ,  G01N2333/475 ,  G01N2500/00

    摘要： A human Vascular IBP-Like Growth Factor polypeptide (VIGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for wound healing or tissue regeneration, stimulating implant fixation and angiogenesis. Antagonists against such polypeptides and their use as a therapeutic to treat atherosclerosis, tumors and scarring are also disclosed. Diagnostic assays for identifying mutations in VIGF nucleic acid sequences and altered levels of the VIGF polypeptide are also disclosed.

    摘要翻译： 公开了一种编码这种多肽的人血管IBP样生长因子多肽（VIGF）和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽用于伤口愈合或组织再生，刺激植入物固定和血管发生的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗动脉粥样硬化，肿瘤和瘢痕形成的治疗剂的用途。 还公开了用于鉴定VIGF核酸序列中的突变和VIGF多肽的改变水平的诊断测定。