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公开(公告)号：US08901308B2
公开(公告)日：2014-12-02
申请号：US13550324
申请日：2012-07-16
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： C07D401/04 , C07D405/04 , C07D417/04 , C07D413/04 , C07D403/04 , C07D403/10 , C07D249/08 , C07D473/00 , C07D249/12 , C07D409/04 , C07D473/34
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US08362055B2
公开(公告)日：2013-01-29
申请号：US12815322
申请日：2010-06-14
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/41 , C07D249/08
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US07825148B2
公开(公告)日：2010-11-02
申请号：US11282119
申请日：2005-11-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/41 , C07D249/04
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US09090569B2
公开(公告)日：2015-07-28
申请号：US12604970
申请日：2009-10-23
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , C07D249/08 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US20120330009A1
公开(公告)日：2012-12-27
申请号：US13550324
申请日：2012-07-16
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： C07D249/12 , C07D417/10 , C07D401/04 , C07D405/10 , C07D473/34 , C07D403/10 , C07D413/10
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US20110105749A1
公开(公告)日：2011-05-05
申请号：US12815322
申请日：2010-06-14
申请人： Weiwen YING , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen YING , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： C07D403/10 , C07D417/10 , C07D413/10 , C07D405/10 , C07D401/10 , C07D249/14 , C07D249/12 , C07D473/34 , C07D413/12 , C07F9/6518
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US20110009397A1
公开(公告)日：2011-01-13
申请号：US12604970
申请日：2009-10-23
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , A61K31/4709 , A61K31/4439 , A61K31/4725 , A61K31/5377 , A61K31/538 , C12N5/00
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US07662813B2
公开(公告)日：2010-02-16
申请号：US11506185
申请日：2006-08-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard P Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard P Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
IPC分类号： A61K31/4196 , A61K31/4025 , A61K31/4523 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D249/08 , C07D207/04 , C07D401/02 , C07D403/02 , C07D413/02
CPC分类号： C07D249/08 , C07D403/10 , C07D403/12 , C07D413/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US20060167070A1
公开(公告)日：2006-07-27
申请号：US11282119
申请日：2005-11-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , C07D403/02 , C07D249/12 , C07D249/08
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US20070155809A1
公开(公告)日：2007-07-05
申请号：US11506185
申请日：2006-08-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
IPC分类号： A61K31/4196 , C07D249/08 , C07D403/02
CPC分类号： C07D249/08 , C07D403/10 , C07D403/12 , C07D413/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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