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公开(公告)号：US20080090887A1
公开(公告)日：2008-04-17
申请号：US11807201
申请日：2007-05-25
申请人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard Ng , Hao Li , Zachary Demko , Dinesh Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
发明人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard Ng , Hao Li , Zachary Demko , Dinesh Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , A61P35/00 , C07D249/12
CPC分类号： C07D417/04 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US08415377B2
公开(公告)日：2013-04-09
申请号：US13229178
申请日：2011-09-09
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D401/14 , C07D403/04 , A61K31/4196 , A61K31/4709
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US20060167070A1
公开(公告)日：2006-07-27
申请号：US11282119
申请日：2005-11-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , C07D403/02 , C07D249/12 , C07D249/08
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
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公开(公告)号：US20070155809A1
公开(公告)日：2007-07-05
申请号：US11506185
申请日：2006-08-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
IPC分类号： A61K31/4196 , C07D249/08 , C07D403/02
CPC分类号： C07D249/08 , C07D403/10 , C07D403/12 , C07D413/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US07662813B2
公开(公告)日：2010-02-16
申请号：US11506185
申请日：2006-08-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard P Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard P Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
IPC分类号： A61K31/4196 , A61K31/4025 , A61K31/4523 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D249/08 , C07D207/04 , C07D401/02 , C07D403/02 , C07D413/02
CPC分类号： C07D249/08 , C07D403/10 , C07D403/12 , C07D413/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US20080004277A1
公开(公告)日：2008-01-03
申请号：US11807331
申请日：2007-05-25
申请人： Dinesh Chimmanamada , Weiwen Ying , Teresa Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
发明人： Dinesh Chimmanamada , Weiwen Ying , Teresa Przewloka , Shijie Zhang , Kevin Foley , Zhenjian Du , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07D249/12 , C07D401/06 , C07D403/12 , C07D413/06
CPC分类号： C07D249/12 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D407/10 , C07D413/10 , C07F9/6518
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译： 本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。 本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物， 或包含这种化合物的组合物。
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公开(公告)号：US20060122156A1
公开(公告)日：2006-06-08
申请号：US11271704
申请日：2005-11-10
申请人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
发明人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/655
CPC分类号： C07D213/75 , C07D213/77 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/56 , C07D251/42 , C07D251/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/10
摘要： This invention relates to compounds of formula (I): their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.
摘要翻译： 本发明涉及式（I）化合物：它们的组成及其使用方法。 化合物（和组合物）可用于调节由IL-12介导的IL-12产生和过程。
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公开(公告)号：US07919487B2
公开(公告)日：2011-04-05
申请号：US11271704
申请日：2005-11-10
申请人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
发明人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/50 , A61K31/53 , A61K31/505 , C07D413/14 , C07D251/02 , C07D401/14
CPC分类号： C07D213/75 , C07D213/77 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/56 , C07D251/42 , C07D251/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/10
摘要： This invention relates to compounds of formula (I): their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.
摘要翻译： 本发明涉及式（I）化合物：它们的组成及其使用方法。 化合物（和组合物）可用于调节由IL-12介导的IL-12产生和过程。
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公开(公告)号：US07615552B2
公开(公告)日：2009-11-10
申请号：US10985627
申请日：2004-11-10
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
IPC分类号： A61K31/517 , A61K31/5377 , C07D265/30 , C07D413/04
CPC分类号： C07D239/95 , C04B35/632 , C07D215/40 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D475/06 , C07D491/04
摘要： This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.
摘要翻译： 本发明提供稠合杂环化合物，化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。
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公开(公告)号：US20060223996A1
公开(公告)日：2006-10-05
申请号：US11272509
申请日：2005-11-10
申请人： Lijun Sun , Elena Kostik , Teresa Przewloka , Howard Ng , Dinesh Chimmanamada , Zachary Demko
发明人： Lijun Sun , Elena Kostik , Teresa Przewloka , Howard Ng , Dinesh Chimmanamada , Zachary Demko
IPC分类号： C07D413/02
CPC分类号： C07D403/12 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to heterocyclic compounds, compositions including the compounds and methods of using and methods of making thereof. The compounds (and compositions) are useful, inter alia, in modulating IL-12 production and processes mediated by IL-12.
摘要翻译： 本发明涉及杂环化合物，包括该化合物的组合物及其使用方法及其制备方法。 化合物（和组合物）尤其用于调节由IL-12介导的IL-12产生和过程。
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