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1.发明授权S-adenosylmethionine-6-N-lysine-methyltransferase from Neurospora crassa, a gene encoding the same, a vector and host cell containing the same, and method for producing trimethyllysine using the host cell 有权来自粗糙脉孢菌的S-腺苷甲硫氨酸-6-N-赖氨酸甲基转移酶，编码它们的基因，含有它们的载体和宿主细胞，以及使用宿主细胞产生三甲基三苯胺的方法公开(公告)号：US07598065B2
公开(公告)日：2009-10-06
申请号：US11994938
申请日：2006-07-07
申请人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
发明人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
CPC分类号： C12P13/08 , C12N9/1085
摘要： Provided is S-adenosylmethionine-6-N-lysine-methyl-transferase obtained from Neurospora crassa, a polynucleotide encoding the same, a vector and host cell containing the polynucleotide, and a method of producing trimethyllysine by culturing the host cell.
摘要翻译： 提供了从粗糙脉孢菌获得的S-腺苷甲硫氨酸-6-N-赖氨酸 - 甲基转移酶，其编码该多核苷酸的多核苷酸，含有多核苷酸的载体和宿主细胞，以及通过培养宿主细胞产生三甲基赖氨酸的方法。
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2.发明申请Microorganism of Enterobacteriacae Genus Haboring Genes Associated With L-Carnitine Biosynthesis and Method of Producing L-Carnitine Using the Microorganism 有权肠杆菌属微生物与L-肉碱生物合成有关的基因和使用微生物生产L-肉碱的方法公开(公告)号：US20080171368A1
公开(公告)日：2008-07-17
申请号：US11994969
申请日：2006-07-07
申请人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
发明人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
CPC分类号： C12N9/1007 , C12N9/0071 , C12N9/88 , C12P13/007
摘要： Provided is a microorganism that belongs to Enterobacteriacae and a method of producing L-carnitine using the same. The microorganism includes polynucleotide encoding activity of S-adenosylmethionine-6-N-iysine KDa methyltransferase from Neurospora crassa, polynucleotide encoding activity of 6-N-trimethyllysine hydroxylase, polynucleotide encoding activity of 3-hydroxy-6-N-trimethyllysine aldolase, and polynucleotide encoding activity of γ-trimethylaminoaldehyde dehydrogenase and y-butyrobetaine hydroxylase.
摘要翻译： 提供属于肠杆菌属的微生物和使用其的L-肉毒碱的生产方法。 微生物包括编码来自粗糙脉孢菌的S-腺苷甲硫氨酸-6-N-依赖型KDa甲基转移酶的活性的多核苷酸，编码6-N-三甲基赖氨酸羟化酶的活性的多核苷酸，3-羟基-6-N-三甲基赖氨酸醛缩酶的活性的多核苷酸和多核苷酸 γ-三甲基氨基醛脱氢酶和γ-丁基甜菜碱羟化酶的编码活性。
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3.发明授权Microorganism of Enterobacteriacae genus haboring genes associated with L-carnitine biosynthesis and method of producing L-carnitine using the microorganism 有权具有与L-肉碱生物合成相关的基因的肠杆菌属的微生物和使用微生物生产L-肉毒碱的方法公开(公告)号：US07718414B2
公开(公告)日：2010-05-18
申请号：US11994969
申请日：2006-07-07
申请人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
发明人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
CPC分类号： C12N9/1007 , C12N9/0071 , C12N9/88 , C12P13/007
摘要： Provided is a microorganism that belongs to Enterobacteriacae and a method of producing L-carnitine using the same. The microorganism includes polynucleotide encoding activity of S-adenosylmethionine-6-N-iysine methyltransferase from Neurospora crassa, polynucleotide encoding activity of 6-N-trimethyllysine hydroxylase, polynucleotide encoding activity of 3-hydroxy-6-N-trimethyllysine aldolase, and polynucleotide encoding activity of γ-trimethylaminoaldehyde dehydrogenase and y-butyrobetaine hydroxylase.
摘要翻译： 提供属于肠杆菌属的微生物和使用其的L-肉毒碱的生产方法。 微生物包括编码来自粗糙脉孢菌的S-腺苷甲硫氨酸-6-N-依赖型甲基转移酶的活性的多核苷酸，编码6-N-三甲基赖氨酸羟化酶活性的多核苷酸，编码3-羟基-6-N-三甲基赖氨酸醛缩酶活性的多核苷酸，以及编码 γ-三甲基氨基醛脱氢酶和γ-丁基甜菜碱羟化酶的活性。
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4.发明申请S-Adenosylmethionine-6-N-Lysine-Methyltransferase From Neurospora Crassa, A Gene Encoding The Same, A Vector And Host Cell Containing The Same, And Method For Producing Trimethyllysine Using The Host Cell 有权来自粗糙脉孢菌的S-腺苷甲硫氨酸-6-N-赖氨酸 - 甲基转移酶，编码它的基因，含有它的载体和宿主细胞以及使用宿主细胞产生三甲基赖氨酸的方法公开(公告)号：US20080199920A1
公开(公告)日：2008-08-21
申请号：US11994938
申请日：2006-07-07
申请人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
发明人： Whan-Koo Kang , Bheong-Uk Lee , Young-Hoon Park , Eun-Sung Koh , Jae-Yeong Ju , Jin-Ho Lee , Hye-Won Kim , Hye-Jin Choi
CPC分类号： C12P13/08 , C12N9/1085
摘要： Provided is S-adenosylmethionine-6-N-lysine-methyl-transferase obtained from Neνrospora crassa, a polynucleotide encoding the same, a vector and host cell containing the polynucleotide, and a method of producing trimethyllysine by culturing the host cell.
摘要翻译： 本发明提供从粗核粗核菌（Nenurospora crassa）获得的S-腺苷甲硫氨酸-6-N-赖氨酸甲基转移酶，其编码该多核苷酸的多核苷酸，含有多核苷酸的载体和宿主细胞，以及通过培养宿主细胞产生三甲基赖氨酸的方法。
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5.发明授权Microorganism of Enterobacteriacae genus harboring genes associated with L-carnitine biosynthesis and method of producing L-carnitine using the microorganism 有权携带与L-肉碱生物合成相关的基因的肠杆菌属的微生物和使用微生物生产L-肉毒碱的方法公开(公告)号：US07901923B2
公开(公告)日：2011-03-08
申请号：US11720008
申请日：2005-07-19
申请人： Bheong-Uk Lee , Whan-Koo Kang , Young-Hoon Park , Eun-Sung Koh , Sung-Oh Chung , Jae-Yeong Ju
发明人： Bheong-Uk Lee , Whan-Koo Kang , Young-Hoon Park , Eun-Sung Koh , Sung-Oh Chung , Jae-Yeong Ju
CPC分类号： C12N9/0006 , C12N9/0071 , C12N9/88 , C12P13/007
摘要： Provided is a microorganism belonging to the family Enterobacteriaceae including: a polynucleotide encoding N-trimethyllysine hydroxylase activity derived from Neurospora crassa; a polynucleotide encoding 3-hydroxy-6-N-trimethyllysine aldolase activity derived from Neurospora crassa; a polynucleotide encoding γ-trimethylaminoaldehyde dehydrogenase activity derived from Neurospora crassa; and a polynucleotide encoding γ-butyrobetaine hydroxylase activity derived from Neurospora crassa. Provided is also a process for producing L-carnitine using the microorganism.
摘要翻译： 提供属于肠杆菌科的微生物，包括：源自粗糙脉孢菌的N-三甲基赖氨酸羟化酶活性的多核苷酸; 编码源自粗糙脉孢菌的3-羟基-6-N-三甲基赖氨酸醛缩酶活性的多核苷酸; 编码源自粗糙脉孢菌的γ-三甲基氨基醛脱氢酶活性的多核苷酸; 以及编码源自粗糙脉孢菌的γ-丁基甜菜碱羟化酶活性的多核苷酸。 还提供了使用微生物生产L-肉毒碱的方法。
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6.发明申请Microorganism of Enterobacteriacae Genus Haboring Genes Associated With L-Carnitine Biosynthesis and Method of Producing L-Carnitine Using the Microorganism 有权肠杆菌属微生物与L-肉碱生物合成有关的基因和使用微生物生产L-肉碱的方法公开(公告)号：US20080102488A1
公开(公告)日：2008-05-01
申请号：US11720008
申请日：2005-07-19
申请人： Bheong-Uk Lee , Whan-Koo Kang , Young-Hoon Park , Eun-Sung Koh , Sung-Oh Chung , Jae-Yeong Ju
发明人： Bheong-Uk Lee , Whan-Koo Kang , Young-Hoon Park , Eun-Sung Koh , Sung-Oh Chung , Jae-Yeong Ju
CPC分类号： C12N9/0006 , C12N9/0071 , C12N9/88 , C12P13/007
摘要： Provided is a microorganism belonging to the family Enterobacteriaceae including: a polynucleotide encoding N-trimethyllysine hydroxylase activity derived from Neurospora crassa; a polynucelotide encoding 3-hydroxy-6-N-trimethyllysine aldolase activity derived from Neurospora crassa; a polynucleotide encoding γ-trimethylaminoaldehyde dehydrogenase activity derived from Neurospora crassa; and a polynucleotide encoding γ-butyrobetaine hydroxylase activity derived from Neurospora crassa. Provided is also a process for producing L-carnitine using the microorganism.
摘要翻译： 提供属于肠杆菌科的微生物，包括：源自粗糙脉孢菌的N-三甲基赖氨酸羟化酶活性的多核苷酸; 编码来自粗糙脉孢菌的3-羟基-6-N-三甲基赖氨酸醛缩酶活性的聚季苷化合物; 编码源自粗糙脉孢菌的γ-三甲基氨基醛脱氢酶活性的多核苷酸; 和编码源自粗糙脉孢菌（Crurospora）的γ-丁酸甜菜碱羟化酶活性的多核苷酸。 还提供了使用微生物生产L-肉毒碱的方法。
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7.发明申请公开(公告)号：US20080050788A1
公开(公告)日：2008-02-28
申请号：US10590831
申请日：2005-02-25
申请人： Sung Oh Chung , Bheonk-Uk Lee , Whan-Koo Kang , Jae Yeong Ju , Eun Sung Koh , Sung-Sik Park , Young-Hoon Park
发明人： Sung Oh Chung , Bheonk-Uk Lee , Whan-Koo Kang , Jae Yeong Ju , Eun Sung Koh , Sung-Sik Park , Young-Hoon Park
CPC分类号： C12N9/0071 , C12P13/007
摘要： Disclosed is a polynucleotide encoding γ-butyrobetaine hydroxylase (γ-BBH) originating from Neurospora crassa. Also disclosed are a recombinant vector comprising the polynucleotide, a transformant transformed with the recombinant vector, γ-BBH encoded by the polynucleotide, and a method of preparing L-carnitine, which comprises hydroxylating γ-butyrobetaine using γ-BBH encoded by the polynucleotide.
摘要翻译： 公开了编码源于粗糙脉孢菌的γ-丁基甜菜碱羟化酶（γ-BBH）的多核苷酸。 还公开了包含多核苷酸的重组载体，用重组载体转化的转化体，由多核苷酸编码的γ-BBH，以及L-肉毒碱的制备方法，该方法包括使用由多核苷酸编码的γ-BBH羟基化γ-丁基甜菜碱。
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公开(公告)号：US08597924B2
公开(公告)日：2013-12-03
申请号：US10590831
申请日：2005-02-25
申请人： Sung Oh Chung , Bheonk-Uk Lee , Whan-Koo Kang , Jae Yeong Ju , Eun Sung Koh , Sung-Sik Park , Young-Hoon Park
发明人： Sung Oh Chung , Bheonk-Uk Lee , Whan-Koo Kang , Jae Yeong Ju , Eun Sung Koh , Sung-Sik Park , Young-Hoon Park
CPC分类号： C12N9/0071 , C12P13/007
摘要： Disclosed is a polynucleotide encoding γ-butyrobetaine hydroxylate (γ-BBH) originating from Neurospora crassa. Also disclosed are a recombinant vector comprising the polynucleotide, a transformant transformed with the recombinant vector, γ-BBH encoded by the polynucleotide, and a method of preparing L-carnitine, which comprises hydroxylating γ-butyrobetaine using γ-BBH encoded by the polynucleotide.
摘要翻译： 公开了编码源于粗糙脉孢菌的γ-丁基甜菜碱羟基化物（γ-BBH）的多核苷酸。 还公开了包含多核苷酸的重组载体，用重组载体转化的转化体，由多核苷酸编码的γ-BBH，以及L-肉毒碱的制备方法，该方法包括使用由多核苷酸编码的γ-BBH羟基化γ-丁基甜菜碱。
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公开(公告)号：US07662943B2
公开(公告)日：2010-02-16
申请号：US11721515
申请日：2005-12-16
申请人： Young-Hoon Park , Hyun-Soo Kim , Hye-Jin Choi , Jin-Ho Lee , Soo-Youn Hwang , Jae-Ick Sim , Tae-Sun Kang , Won-Sik Lee
发明人： Young-Hoon Park , Hyun-Soo Kim , Hye-Jin Choi , Jin-Ho Lee , Soo-Youn Hwang , Jae-Ick Sim , Tae-Sun Kang , Won-Sik Lee
CPC分类号： C07K14/34
摘要： Provided are a promoter including at least one polynucleotide selected from the group consisting of SEQ ID NOS: 1 to 7, an expression cassette including the same, a vector including the expression cassette, a host cell including the vector, and a method of expressing a gene using the host cell.
摘要翻译： 提供了包含选自SEQ ID NO：1至7的至少一种多核苷酸的启动子，包含其的表达盒，包含表达盒的载体，包含载体的宿主细胞，以及表达 基因使用宿主细胞。
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10.发明申请Novel Promoter Nucleic Acid Derived From Corynebacterium Genus Bacteria, Expression Cassette Comprising The Promoter And Vector Comprising The Cassette, Host Cell Comprising The Vector And Method For Expressing A Gene Using The Cell 有权由棒状杆菌属细菌衍生的新型启动子核酸，包含包含载体的启动子和载体的表达盒和包含载体的宿主细胞和使用细胞表达基因的方法公开(公告)号：US20080138859A1
公开(公告)日：2008-06-12
申请号：US11721515
申请日：2005-12-16
申请人： Young-Hoon Park , Hyun-Soo Kim , Hye-Jin Choi , Jin-Ho Lee , Soo-Youn Hwang , Jae-Ick Sim , Tae-Sun Kang , Won-Sik Lee
发明人： Young-Hoon Park , Hyun-Soo Kim , Hye-Jin Choi , Jin-Ho Lee , Soo-Youn Hwang , Jae-Ick Sim , Tae-Sun Kang , Won-Sik Lee
CPC分类号： C07K14/34
摘要： Provided are a promoter including at least one polynucleotide selected from the group consisting of SEQ ID NOS: 1 to 7, an expression cassette including the same, a vector including the expression cassette, a host cell including the vector, and a method of expressing a gene using the host cell.
摘要翻译： 提供了包含选自SEQ ID NO：1至7的至少一种多核苷酸的启动子，包含其的表达盒，包含表达盒的载体，包含载体的宿主细胞，以及表达 基因使用宿主细胞。
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