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公开(公告)号：US12121670B1
公开(公告)日：2024-10-22
申请号：US18208064
申请日：2023-06-09
申请人： William Brubaker , Paul Davis
发明人： William Brubaker , Paul Davis
CPC分类号： A61M25/0017 , A61M25/002 , A61M25/0043 , A61M25/0045 , A61M25/0111 , A61M25/1006 , A61M25/1018 , A61M39/10 , A61F5/44 , A61M25/00 , A61M2025/0046 , A61M2025/0056 , A61M2210/1089
摘要： The urinary catheter includes a balloon that anchors a distal end of a catheter lumen in position inside of the bladder. It includes a port open to the inner lumen at the distal end of the catheter to allow for the flow of urine from the bladder, through the catheter, and to the connected drainage bag. A drainage bag collects urine from the catheter. The drainage bag has an inlet port for receiving urine and an outlet port for draining urine from the drainage bag. There is often collection tubing that connected the catheter to the drainage bag. A lock device provides that the inlet port of the drainage bag and the outlet port of the urinary catheter remain coupled together.
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公开(公告)号：US20070078139A1
公开(公告)日：2007-04-05
申请号：US11602283
申请日：2006-11-21
申请人： Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
发明人： Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
IPC分类号： A61K31/505 , A61K31/4965 , A61K31/44 , A61K31/426 , A61K31/47 , A61K31/381 , A61K31/34 , A61K31/137
CPC分类号： C07D213/74 , A61K31/137 , A61K31/16 , A61K31/34 , A61K31/381 , A61K31/426 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/4965 , A61K31/505 , C07C217/92 , C07C229/60 , C07D211/26 , C07D213/38 , C07D213/61 , C07D213/80 , C07D215/12 , C07D217/22 , C07D241/12 , C07D277/28 , C07D307/20 , C07D307/52 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07F7/1804
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.
摘要翻译： 通过新化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。 本发明的化合物是式I的化合物：其中R 1，R 2，R 3和R 4， >如本文所定义。
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公开(公告)号：US20110046146A9
公开(公告)日：2011-02-24
申请号：US11602283
申请日：2006-11-21
申请人： Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
发明人： Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
IPC分类号： A61K31/505 , A61K31/4965 , A61K31/44 , A61K31/426 , A61K31/47 , A61K31/381 , A61K31/34 , A61K31/137
CPC分类号： C07D213/74 , A61K31/137 , A61K31/16 , A61K31/34 , A61K31/381 , A61K31/426 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/4965 , A61K31/505 , C07C217/92 , C07C229/60 , C07D211/26 , C07D213/38 , C07D213/61 , C07D213/80 , C07D215/12 , C07D217/22 , C07D241/12 , C07D277/28 , C07D307/20 , C07D307/52 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07F7/1804
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.
摘要翻译： 通过新化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。 本发明的化合物具有式I：其中R 1，R 2，R 3和R 4如本文所定义。
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4.发明申请Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs 失效磷酸二酯酶4抑制剂，包括N-取代苯胺和二苯胺类似物公开(公告)号：US20050119225A1
公开(公告)日：2005-06-02
申请号：US10622833
申请日：2003-07-21
申请人： Richard Schumacher , Allen Hopper , Ashok Tehim , Hans-Jurgen Hess , Axel Unterbeck , Erik Kuester , William Brubaker , Robert Dunn
发明人： Richard Schumacher , Allen Hopper , Ashok Tehim , Hans-Jurgen Hess , Axel Unterbeck , Erik Kuester , William Brubaker , Robert Dunn
IPC分类号： A61K31/135 , A61K31/36 , A61K31/40 , A61K31/41 , A61K31/695 , A61P25/00 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/92 , C07C229/60 , C07D213/38 , C07D213/61 , C07D213/68 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/80 , C07D215/12 , C07D215/14 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/12 , C07D241/20 , C07D261/08 , C07D261/14 , C07D277/28 , C07D295/13 , C07D307/14 , C07D307/20 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
CPC分类号： C07D241/12 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/92 , C07C229/60 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D213/61 , C07D213/68 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/80 , C07D215/12 , C07D215/14 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D261/08 , C07D261/14 , C07D277/28 , C07D295/13 , C07D307/14 , C07D307/20 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3 and R4 are as defined herein.
摘要翻译： 通过新化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。 本发明的化合物是式I的化合物：其中R 1，R 2，R 3和R 4， >如本文所定义。
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