-
公开(公告)号：US20100033724A1
公开(公告)日：2010-02-11
申请号：US12355534
申请日：2009-01-16
申请人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
发明人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
IPC分类号： G01N21/55
CPC分类号： G01N21/552 , G01N21/47 , G01N33/54346 , G01N33/54373 , G01N2015/0038
摘要： An apparatus and method for imaging metallic nanoparticles. The invention teaches an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, and illumination module, an input module, and an output module. The apparatus may have a stationary substrate holder and imaging module which are proximate to one another. The apparatus provides for a compact system without the need for complex motorized devices to move a camera across the substrate. Further, the apparatus and method provide for automatic detection of the spots/wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics.
摘要翻译： 用于金属纳米颗粒成像的装置和方法。 本发明教导了用于检测金胶体颗粒并且准确地向操作者报告的装置和方法。 该装置包括用于保持基板的基板保持器，处理器和存储器件，成像模块和照明模块，输入模块和输出模块。 该装置可以具有彼此靠近的固定衬底保持器和成像模块。 该装置提供紧凑的系统，而不需要复杂的电动装置来移动照相机跨越衬底。 此外，该装置和方法提供对基板上的点/孔的自动检测，基板上的点的自动定量，以及基于判定统计的斑点的自动解释。
-
公开(公告)号：US07773790B2
公开(公告)日：2010-08-10
申请号：US11530110
申请日：2006-09-08
申请人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
发明人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
IPC分类号： G06K9/00
CPC分类号： G01N33/54346 , G01N21/253
摘要： An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, an illumination module, a power module, an input module, and an output module. The apparatus may have a stationary substrate holder and imaging module which are proximate to one another. The apparatus provided for a compact sized system without the need for complex motorized devices to move the camera across the substrate. Further, the apparatus and method provide for automatic detection of the spots/wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics.
摘要翻译： 提供了一种用于成像金属纳米颗粒的设备和方法。 优选地，本发明提供了用于检测金胶体颗粒并且准确地向操作者报告的装置和方法。 该装置包括用于保持基板的基板支架，处理器和存储装置，成像模块，照明模块，电源模块，输入模块和输出模块。 该装置可以具有彼此靠近的固定衬底保持器和成像模块。 该设备提供了一种紧凑型系统，而不需要复杂的电动装置来使相机移动穿过基板。 此外，该装置和方法提供对基板上的点/孔的自动检测，基板上的点的自动定量，以及基于判定统计的斑点的自动解释。
-
3.发明申请公开(公告)号：US20120063653A1
公开(公告)日：2012-03-15
申请号：US12853047
申请日：2010-08-09
申请人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
发明人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
IPC分类号： G06K9/00
CPC分类号： G01N33/54346 , G01N21/253
摘要： An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, an illumination module, a power module, an input module, and an output module. The apparatus may have a stationary substrate holder and imaging module which are proximate to one another. The apparatus provided for a compact sized system without the need for complex motorized devices to move the camera across the substrate. Further, the apparatus and method provide for automatic detection of the spots/wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics.
摘要翻译： 提供了一种用于成像金属纳米颗粒的设备和方法。 优选地，本发明提供了用于检测金胶体颗粒并且准确地向操作者报告的装置和方法。 该装置包括用于保持基板的基板支架，处理器和存储装置，成像模块，照明模块，电源模块，输入模块和输出模块。 该装置可以具有彼此靠近的固定衬底保持器和成像模块。 该设备提供了一种紧凑型系统，而不需要复杂的电动装置来使相机移动穿过基板。 此外，该装置和方法提供对基板上的点/孔的自动检测，基板上的点的自动定量，以及基于判定统计的斑点的自动解释。
-
公开(公告)号：US20070148665A1
公开(公告)日：2007-06-28
申请号：US11530138
申请日：2006-09-08
申请人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
发明人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
CPC分类号： G01N33/54346 , G01N21/253
摘要： An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, an illumination module, a power module, an input module, and an output module. The apparatus may have a stationary substrate holder and imaging module which are proximate to one another. The apparatus provided for a compact sized system without the need for complex motorized devices to move the camera across the substrate. Further, the apparatus and method provide for automatic detection of the spots/wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics.
摘要翻译： 提供了一种用于成像金属纳米颗粒的设备和方法。 优选地，本发明提供了用于检测金胶体颗粒并且准确地向操作者报告的装置和方法。 该装置包括用于保持基板的基板支架，处理器和存储装置，成像模块，照明模块，电源模块，输入模块和输出模块。 该装置可以具有彼此靠近的固定衬底保持器和成像模块。 该设备提供了一种紧凑型系统，而不需要复杂的电动装置来使相机移动穿过基板。 此外，该装置和方法提供对基板上的点/孔的自动检测，基板上的点的自动定量，以及基于判定统计的斑点的自动解释。
-
公开(公告)号：US20070041624A1
公开(公告)日：2007-02-22
申请号：US11530110
申请日：2006-09-08
申请人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
发明人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
IPC分类号： G06K9/00
CPC分类号： G01N33/54346 , G01N21/253
摘要： An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, an illumination module, a power module, an input module, and an output module. The apparatus may have a stationary substrate holder and imaging module which are proximate to one another. The apparatus provided for a compact sized system without the need for complex motorized devices to move the camera across the substrate. Further, the apparatus and method provide for automatic detection of the spots/wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics.
摘要翻译： 提供了一种用于成像金属纳米颗粒的设备和方法。 优选地，本发明提供了用于检测金胶体颗粒并且准确地向操作者报告的装置和方法。 该装置包括用于保持基板的基板支架，处理器和存储装置，成像模块，照明模块，电源模块，输入模块和输出模块。 该装置可以具有彼此靠近的固定衬底保持器和成像模块。 该设备提供了一种紧凑型系统，而不需要复杂的电动装置来使相机移动穿过基板。 此外，该装置和方法提供对基板上的点/孔的自动检测，基板上的点的自动定量，以及基于判定统计的斑点的自动解释。
-
公开(公告)号：US07110585B2
公开(公告)日：2006-09-19
申请号：US10210959
申请日：2002-08-02
申请人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
发明人： William Cork , Tim Patno , Mark Weber , Dave Morrow , Wesley Buckingham
IPC分类号： G06K9/00
CPC分类号： G01N33/54346 , G01N21/253
摘要： An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, an illumination module, a power module, an input module, and an output module. The apparatus may have a stationary substrate holder and imaging module which are proximate to one another. The apparatus provided for a compact sized system without the need for complex motorized devices to move the camera across the substrate. Further, the apparatus and method provide for automatic detection of the spots/wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics.
-
7.发明授权公开(公告)号：US07888107B2
公开(公告)日：2011-02-15
申请号：US11491564
申请日：2006-07-24
申请人： Tim Patno , Tom Westberg , Mark Weber , Benjamin Rush , Christopher Khoury , David Morrow , Janusz Ruszel , Christian Kronshage , William Cork
发明人： Tim Patno , Tom Westberg , Mark Weber , Benjamin Rush , Christopher Khoury , David Morrow , Janusz Ruszel , Christian Kronshage , William Cork
CPC分类号： G01N35/1097 , G01N35/08 , Y10T436/25
摘要： A method and apparatus are provided for processing a nucleic acid. The apparatus includes a disposable self-contained processing module that contains the nucleic acid and substantially all of the fluids to effect a nanoparticle hybridization test, a pump coupled to the processing module, a valving system disposed between the pump and processing module and a control system coupled to the pump and valving system causing the processing fluids to interact with the nucleic acid to effect a sandwich hybridization test using nanoparticles.
摘要翻译： 提供了一种用于处理核酸的方法和装置。 该设备包括一次性独立处理模块，其包含核酸和基本上所有的流体以进行纳米颗粒杂交测试，耦合到处理模块的泵，设置在泵和处理模块之间的阀系统和控制系统 耦合到泵和阀系统，导致处理流体与核酸相互作用以进行使用纳米颗粒的夹心杂交测试。
-
公开(公告)号：US20080268458A1
公开(公告)日：2008-10-30
申请号：US12169618
申请日：2008-07-08
申请人： Tim Patno , Jennifer Hollenstein , Christian Kronshage , Christopher Khoury , Mark Weber , Tom Westberg , William Cork
发明人： Tim Patno , Jennifer Hollenstein , Christian Kronshage , Christopher Khoury , Mark Weber , Tom Westberg , William Cork
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/5025 , B01L3/5027 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2300/0877 , B01L2400/0487 , G01N35/1097 , C12Q2563/155 , C12Q2565/519
摘要： A method is provided for preparing a test sample for detecting a predetermined target nucleic acid. The method includes the steps of providing a test probe comprising an oligonucleotide attached to a nanoparticle and providing a hybridization unit containing the test sample and the test probe, wherein said hybridization unit further includes a target sample substrate and a distribution manifold coupled to a first side of the substrate. The method further includes the steps of clamping a processing fluids manifold to the distribution manifold of the hybridization unit, denaturing the test sample and preparing the test sample for detecting the predetermined target nucleic acid by pumping a plurality of processing fluids between the processing fluids source manifold and distribution manifold to hybridize the test probe and predetermined target nucleic acid to the target sample substrate, to wash the hybridized sample and to amplify a detectable parameter of the hybridized sample.
摘要翻译： 提供了一种制备用于检测预定靶核酸的测试样品的方法。 该方法包括以下步骤：提供包含与纳米颗粒连接的寡核苷酸并提供含有测试样品和测试探针的杂交单元的测试探针，其中所述杂交单元还包括目标样品基底和连接到第一侧的分布歧管 的基底。 该方法还包括以下步骤：将加工流体歧管夹紧到杂交单元的分配歧管上，使测试样品变性并制备用于通过在处理流体源歧管之间泵送多个处理流体来检测预定靶核酸的测试样品 以及分配多肽以将测试探针和预定靶核酸与目标样品底物杂交，以洗涤杂交样品并扩增杂交样品的可检测参数。
-
9.发明申请公开(公告)号：US20110008907A1
公开(公告)日：2011-01-13
申请号：US11491564
申请日：2006-07-24
申请人： Tim Patno , Tom Westberg , Mark Weber , Benjamin Rush , Christopher Khoury , David Morrow , Janusz Ruszel , Christian Kronshage , William Cork
发明人： Tim Patno , Tom Westberg , Mark Weber , Benjamin Rush , Christopher Khoury , David Morrow , Janusz Ruszel , Christian Kronshage , William Cork
CPC分类号： G01N35/1097 , G01N35/08 , Y10T436/25
摘要： A method and apparatus are provided for processing a nucleic acid. The apparatus includes a disposable self-contained processing module that contains the nucleic acid and substantially all of the fluids to effect a nanoparticle hybridization test, a pump coupled to the processing module, a valving system disposed between the pump and processing module and a control system coupled to the pump and valving system causing the processing fluids to interact with the nucleic acid to effect a sandwich hybridization test using nanoparticles.
摘要翻译： 提供了一种用于处理核酸的方法和装置。 该设备包括一次性独立处理模块，其包含核酸和基本上所有的流体以进行纳米颗粒杂交测试，耦合到处理模块的泵，设置在泵和处理模块之间的阀系统和控制系统 耦合到泵和阀系统，导致处理流体与核酸相互作用以进行使用纳米颗粒的夹心杂交测试。
-
公开(公告)号：US07396677B2
公开(公告)日：2008-07-08
申请号：US10703368
申请日：2003-11-07
申请人： Tim Patno , Jennifer Hollenstein , Christian Kronshage , Christopher Khoury , Mark Weber , Tom Westberg , William Cork
发明人： Tim Patno , Jennifer Hollenstein , Christian Kronshage , Christopher Khoury , Mark Weber , Tom Westberg , William Cork
CPC分类号： C12Q1/6806 , B01L3/5025 , B01L3/5027 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2300/0877 , B01L2400/0487 , G01N35/1097 , C12Q2563/155 , C12Q2565/519
摘要： A method and apparatus are provided for preparing a test sample for detecting a predetermined target nucleic acid. The method includes the steps of providing a test probe comprising an oligonucleotide attached to a nanoparticle and providing a hybridization unit containing the test sample and the test probe, wherein said hybridization unit further includes a target sample substrate and a distribution manifold coupled to a first side of the substrate. The method further includes the steps of clamping a processing fluids manifold to the distribution manifold of the hybridization unit, denaturing the test sample and preparing the test sample for detecting the predetermined target nucleic acid by pumping a plurality of processing fluids between the processing fluids source manifold and distribution manifold to hybridize the test probe and predetermined target nucleic acid to the target sample substrate, to wash the hybridized sample and to amplify a detectable parameter of the hybridized sample.
摘要翻译： 提供了一种制备用于检测预定靶核酸的测试样品的方法和装置。 该方法包括以下步骤：提供包含与纳米颗粒连接的寡核苷酸并提供含有测试样品和测试探针的杂交单元的测试探针，其中所述杂交单元还包括目标样品基底和连接到第一侧的分布歧管 的基底。 该方法还包括以下步骤：将加工流体歧管夹紧到杂交单元的分配歧管上，使测试样品变性并制备用于通过在处理流体源歧管之间泵送多个处理流体来检测预定靶核酸的测试样品 以及分配多肽以将测试探针和预定靶核酸与目标样品底物杂交，以洗涤杂交样品并扩增杂交样品的可检测参数。
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.028 秒)
