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公开(公告)号：US20110135569A1
公开(公告)日：2011-06-09
申请号：US12531825
申请日：2008-03-19
CPC分类号： A61K51/0491 , Y10T137/0402
摘要： Methods are provided for the local radiotherapy of cancers such as locally invasive, advanced stage solid tumors, and normal tissues penetrated by processes of cancerous tissue, through administration of Auger-electron emitting radionucleoside analogs using high-flow microinfusion techniques (“convection-enhanced delivery”). Direct infusion under pressure, at flow rates in excess of at least about 0.5 microliters/min of the radionucleosides provides for their mass transport through tissue to a much higher degree than could be achieved by passive, unpressurized diffusion. The unique properties of these radionucleoside analogs that provide for surprisingly effacacious delivery by high-flow microinfusion include rapid clearance from tissues following local injection without the benefit of sustained high-flow microinfusion, rapid and complete clearance via the blood stream, poor permeation of barriers such as the blood-brain barrier, and a highly potent, non-selective, but very short range killing effect on cells that are undergoing DNA replication that incorporate radionucleosides into their chromosomes.
摘要翻译： 通过使用高流量微灌注技术（“对流增强递送”）施用俄歇电子发射放射性核苷类似物，为局部放射治疗癌症的局部放疗提供了方法，例如局部侵袭性，晚期实体瘤和由癌组织进程穿透的正常组织 “）。 在压力下直接输注超过至少约0.5微升/分钟的放射性核苷的流速提供了它们通过组织传播的程度比通过被动的，未加压的扩散可以达到的程度高得多。 这些放射性核苷类似物的独特性质，通过高流量微灌注提供令人惊讶的高效递送，包括局部注射后从组织快速清除，而不受持续高流量微灌注的影响，通过血流快速和完全清除，障碍物渗透差 作为血脑屏障，以及对正在经历DNA复制的细胞的非常有效，非选择性但非常短程的杀伤作用，其将放射性核苷掺入染色体。
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公开(公告)号：US08600479B2
公开(公告)日：2013-12-03
申请号：US12531808
申请日：2008-03-20
申请人： William D. Dalke , Kevin Lillehei , Thomas A. Jellison , Michael J. Gerber , James E. Matsuura , Stephen L Warren
发明人： William D. Dalke , Kevin Lillehei , Thomas A. Jellison , Michael J. Gerber , James E. Matsuura , Stephen L Warren
IPC分类号： A61B5/05
CPC分类号： A61K51/0491 , Y10T137/0402
摘要： A catheter system adapted for navigating, guiding and implanting a catheter or a plurality of catheters in a spatially-defined implantation within the tissue of a patient is provided. The system can include a tissue navigation system and a probe to inform the navigation system to guide emplacement of the catheters within a target tissue. The probe can provide images, such as fiberoptic visual images, or ultrasound images, or can provide radiolocation data, to guide the catheter emplacement. The catheters supply a pressurized liquid including a bioactive agent, such as can be used in the treatment of cancer, for example 123I- or 125I-IUDR. The system and methods provided can be used in the treatment of locally advanced tumors, such as cancers of the brain, head or neck, esophagus, prostate, ovary, liver, pancreas, bladder or rectum.
摘要翻译： 提供了一种导管系统，其适于在病人组织内的空间限定的植入物中导航，引导和植入导管或多个导管。 该系统可以包括组织导航系统和探针，以通知导航系统来引导导管在目标组织内的位置。 探针可以提供诸如光学视觉图像或超声图像的图像，或者可以提供无线电定位数据来引导导管放置。 导管提供包括生物活性剂的加压液体，例如可用于治疗癌症，例如123I-或125I-IUDR。 提供的系统和方法可用于局部晚期肿瘤的治疗，如脑，头颈部，食管，前列腺，卵巢，肝，胰腺，膀胱或直肠癌。
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公开(公告)号：US20100222668A1
公开(公告)日：2010-09-02
申请号：US12531808
申请日：2008-03-20
申请人： William D. Dalke , Kevin Lillehei , Thomas A. Jellison , Michael J. Gerber , James E. Matsuura , Stephen L. Warren
发明人： William D. Dalke , Kevin Lillehei , Thomas A. Jellison , Michael J. Gerber , James E. Matsuura , Stephen L. Warren
CPC分类号： A61K51/0491 , Y10T137/0402
摘要： A catheter system adapted for navigating, guiding and implanting a catheter or a plurality of catheters in a spatially-defined implantation within the tissue of a patient is provided. The system can include a tissue navigation system and a probe to inform the navigation system to guide emplacement of the catheters within a target tissue. The probe can provide images, such as fiberoptic visual images, or ultrasound images, or can provide radiolocation data, to guide the catheter emplacement. The catheters supply a pressurized liquid including a bioactive agent, such as can be used in the treatment of cancer, for example 123I- or 125I-IUDR. The system and methods provided can be used in the treatment of locally advanced tumors, such as cancers of the brain, head or neck, esophagus, prostate, ovary, liver, pancreas, bladder or rectum.
摘要翻译： 提供了一种导管系统，其适于在病人组织内的空间限定的植入物中导航，引导和植入导管或多个导管。 该系统可以包括组织导航系统和探针，以通知导航系统来引导导管在目标组织内的位置。 探针可以提供诸如光学视觉图像或超声图像的图像，或者可以提供无线电定位数据来引导导管放置。 导管提供包括生物活性剂的加压液体，例如可用于治疗癌症，例如123I-或125I-IUDR。 提供的系统和方法可用于局部晚期肿瘤的治疗，如脑，头颈部，食管，前列腺，卵巢，肝，胰腺，膀胱或直肠癌。
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公开(公告)号：USH1324H
公开(公告)日：1994-06-07
申请号：US941389
申请日：1992-09-08
CPC分类号： A61M1/367 , A61M1/3609 , A61M1/3664
摘要： A system for controlling and monitoring the extracorporeal circulation of fluids, which is particularly useful in controlling and monitoring the circulation of blood and cardioplegia solution in surgical procedures. A set of perfusion assemblies are mounted in a transportable console, each perfusion assembly having a separable pump and control module pod. Virtually all the instrumentation for the monitoring and controlling of the pump and the fluid being pumped by that perfusion assembly are present on the pump and control module pod for that perfusion assembly, without the need for any separate control screen. Further, the perfusion assembly uses removable circuit cards and associated instrumentation strips to custom configure the perfusion assembly for each application. The perfusion assembly thereby provides complete information at a glance and complete control of the perfusion assembly by using dedicated controls that are grouped to each perfusion assembly. It is flexible in being configured to the desires of the user, is easy to use and involves a minimum of clutter.
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公开(公告)号：US5693039A
公开(公告)日：1997-12-02
申请号：US190309
申请日：1994-02-02
CPC分类号： A61M1/3627 , A61M1/3624 , A61M1/3636 , A61M2205/3386 , A61M2205/3389
摘要： A venous reservoir bag subassembly which is adapted to cooperate with a mounting assembly having a bracket frame and a front plate reproducibly relatively movable to enable constant accurate blood volume readout, a cooperating mechanism between the subassembly and the mounting assembly to provide against unduly low blood volume, and an angled conduit cooperating with the bag and recesses in the subassembly and assembly to provide further failsafe against passage of the undesirable gas.
摘要翻译： 一种静脉储存袋子组件，其适于与具有可重复地相对移动的支架框架和前板的安装组件配合，以使得能够恒定精确地进行血液量读出，该子组件与安装组件之间的配合机构能够防止过低的血液体积 以及与组件和组件中的袋和凹部配合的成角度的导管，以提供不利于不期望的气体通过的进一步的故障保护。
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公开(公告)号：US20120109037A1
公开(公告)日：2012-05-03
申请号：US13285642
申请日：2011-10-31
申请人： Bruce S. Ellingboe , William D. Dalke , J. Steven Ingebrigtsen , John J. Kappus , Bruce E. Lawrence , Mike E. Schwab , Gary A. Carson , Kevin J. Kollar
发明人： Bruce S. Ellingboe , William D. Dalke , J. Steven Ingebrigtsen , John J. Kappus , Bruce E. Lawrence , Mike E. Schwab , Gary A. Carson , Kevin J. Kollar
IPC分类号： A61M1/16
CPC分类号： A61M1/32 , A61M1/322 , A61M1/3621 , A61M1/3624 , A61M1/3626 , A61M1/3632 , A61M1/3639 , A61M1/3641 , A61M1/3643 , A61M1/3644 , A61M1/3663 , A61M1/3664 , A61M1/3666 , A61M1/3667 , A61M2205/123 , A61M2205/128 , A61M2205/3389 , A61M2205/505 , A61M2205/705 , A61M2205/707 , A61M2209/082
摘要： An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.
摘要翻译： 体外血液灌注系统包括一次性组件和具有控制界面区域的控制单元。 界面区域包括用于选择性泵送静脉血，动脉血，心麻痹液，从左心室移除的抽吸血液和血液的泵组件。 阀组件控制通过组件和/或从患者流出的流体，并且传感器监测各种流体参数，包括各种流体回路内的温度和压力。 用户界面是用于实现控制单元和阀组件操作的功能屏幕界面。 屏幕界面可以是具有对应于组件接口区域的对象的触摸屏。 可以选择性地控制显示器以提供具有相应的叙述指令的一次性组装部件的图形描绘。
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7.发明授权
公开(公告)号：US5957137A
公开(公告)日：1999-09-28
申请号：US997367
申请日：1997-12-23
CPC分类号： A61M1/3664 , G05D11/132
摘要： A method and apparatus for preparing a cardioplegia mixture is provided which allows an increased level of control over the flow rate, dilution ration and concentration of cardioplegia inducing components in cardioplegia mixture during cardiovascular surgery. The method for preparing the cardioplegia mixture includes the steps of combining first and second crystalloid solutions of different concentrations to establish a total volume flow rate of combined solutions. The flow rate of the first crystalloid solution is self adjusted to equal the established total volume flow rate minus the established volume flow rate of the second crystalloid solution. The apparatus for preparing a cardioplegia mixture includes first and second crystalloid solutions containing a cardioplegia inducing component at different concentrations, and means for flowing and combining the solutions and establishing a total volume flow rate of the combined solution. The apparatus further includes means for self-adjustment of the flow rate of the first crystalloid solution to equal total the volume flow rate minus the established volume flow rate of the second crystalloid solution. The apparatus preferably includes a disposable tubing set for flowing, combining, and interconnecting the crystalloid solutions.
摘要翻译： 提供了一种用于制备心麻痹混合物的方法和装置，其允许在心血管手术期间增加对心麻痹混合物中的心麻痹诱导成分的流速，稀释比例和浓度的控制。 制备心麻痹混合物的方法包括将不同浓度的第一和第二晶体溶液组合以建立组合溶液的总体积流速的步骤。 自调节第一晶体溶液的流速，以等于建立的总体积流量减去第二晶体溶液的建立的体积流量。 用于制备心麻痹混合物的装置包括含有不同浓度的心麻痹诱导成分的第一和第二晶体溶液，以及用于流动和组合溶液并建立组合溶液的总体积流速的装置。 该装置还包括用于自动调节第一晶体溶液的流速等于总体积流量减去第二晶体溶液的建立体积流量的装置。 该装置优选地包括用于流动，组合和互连晶体溶液的一次性管组。
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公开(公告)号：US5720741A
公开(公告)日：1998-02-24
申请号：US481752
申请日：1995-06-07
CPC分类号： A61M1/3627 , A61M1/3624 , A61M1/3636 , A61M2205/3386 , A61M2205/3389
摘要： A venous reservoir bag subassembly is provided which is adapted to cooperate with a mounting assembly having a bracket frame and a front plate reproducibly relatively movable to enable constant accurate blood volume readout, cooperating means between the subassembly and the mounting assembly to provide against unduly low blood volume, and angled conduit means cooperating with the bag and recesses in the subassembly and assembly to provide further failsafe against passage of the undesirable gas.
摘要翻译： 提供了静脉储存袋子组件，其适于与具有可重复地相对移动的支架框架和前板的安装组件配合，以使得能够恒定精确地进行血液量读出，在组件与安装组件之间配合装置以防止过低的血液 体积和成角度的管道装置与子组件和组件中的袋和凹部配合以提供进一步的故障保护以防止不期望的气体的通过。
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公开(公告)号：US08057419B2
公开(公告)日：2011-11-15
申请号：US11333671
申请日：2006-01-17
申请人： Bruce S. Ellingboe , William D. Dalke , J. Steven Ingebrigtsen , John J. Kappus , Bruce E. Lawrence , Mike E. Schwab , Gary A. Carson , Kevin J. Kollar
发明人： Bruce S. Ellingboe , William D. Dalke , J. Steven Ingebrigtsen , John J. Kappus , Bruce E. Lawrence , Mike E. Schwab , Gary A. Carson , Kevin J. Kollar
IPC分类号： A61M37/00
CPC分类号： A61M1/32 , A61M1/322 , A61M1/3621 , A61M1/3624 , A61M1/3626 , A61M1/3632 , A61M1/3639 , A61M1/3641 , A61M1/3643 , A61M1/3644 , A61M1/3663 , A61M1/3664 , A61M1/3666 , A61M1/3667 , A61M2205/123 , A61M2205/128 , A61M2205/3389 , A61M2205/505 , A61M2205/705 , A61M2205/707 , A61M2209/082 , G06F19/00
摘要： An extracorporeal blood perfusion system includes a disposable assembly and a control unit having a control interface region. The interface region includes pump assemblies for selective pumping of venous blood, arterial blood, cardioplegia solution, suctioned blood and blood removed from the left ventricle. Valve assemblies control the flow of fluids through the assembly and to/from the patient and sensors monitor various fluid parameters including temperature and pressure within the various fluid circuits. The user interface is a functional screen interface for effecting the operation of the control unit and valve assemblies. The screen interface may be a touch screen having objects that corresponds to the component interface region. The display may be selectively controlled to provide graphic depictions of disposable assembly components with corresponding narrative instructions.
摘要翻译： 体外血液灌注系统包括一次性组件和具有控制界面区域的控制单元。 界面区域包括用于选择性泵送静脉血，动脉血，心麻痹液，从左心室移除的抽吸血液和血液的泵组件。 阀组件控制通过组件和/或从患者流出的流体，并且传感器监测各种流体参数，包括各种流体回路内的温度和压力。 用户界面是用于实现控制单元和阀组件操作的功能屏幕界面。 屏幕界面可以是具有对应于组件接口区域的对象的触摸屏。 可以选择性地控制显示器以提供具有相应的叙述指令的一次性组装部件的图形描绘。
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公开(公告)号：US5352218A
公开(公告)日：1994-10-04
申请号：US725126
申请日：1991-07-03
CPC分类号： A61M1/3627 , A61M1/3624 , A61M1/3636 , A61M2205/3386 , A61M2205/3389
摘要： A venous reservoir bag subassembly is provided which is adapted to cooperate with a mounting assembly having a bracket frame and a front plate reproducibly relatively movable to enable constant accurate blood volume readout, cooperating means between the subassembly and the mounting assembly to provide against unduly low blood volume, and angled conduit means cooperating with the bag and recesses in the subassembly and assembly to provide further failsafe against passage of the undesirable gas.
摘要翻译： 提供了静脉储存袋子组件，其适于与具有可重复地相对移动的支架框架和前板的安装组件配合，以使得能够恒定精确地进行血液量读出，在组件与安装组件之间配合装置以防止过低的血液 体积和成角度的管道装置与子组件和组件中的袋和凹部配合以提供进一步的故障保护以防止不期望的气体的通过。
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