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18 条记录 (耗时 0.025 秒)

    Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action
    7.
    发明授权
    Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action 有权

    公开(公告)号：US06432987B1

    公开(公告)日：2002-08-13

    申请号：US09736431

    申请日：2000-12-15

    申请人： Eckhard Gunther ,  Peter Emig ,  Dietmar Reichert ,  Guillaume Le Baut ,  Bernd Nickel ,  Gerald Bacher

    发明人： Eckhard Gunther ,  Peter Emig ,  Dietmar Reichert ,  Guillaume Le Baut ,  Bernd Nickel ,  Gerald Bacher

    IPC分类号： A01N4340

    摘要： The invention relates to novel, substituted N-benzyl-indol-3-ylglyoxylic acid derivatives of the following formula and their use for the treatment of oncoses The invention further relates to their physiologically tolerable acid addition salts and if possible their N-oxides. In addition, the invention relates to pharmaceutical preparations containing at least one of the compounds of the abovementioned formula or their salts or N-oxides with physiologically tolerable inorganic or organic acids and, if appropriate, pharmaceutically utilizable vehicles and/or diluents or excipients and also administration forms of the compounds of the abovementioned formula containing at least one of the compounds of this formula or their salts in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments

    IN-PROCESS CONTROL IN A METHOD FOR PRODUCING EPO
    8.
    发明申请
    IN-PROCESS CONTROL IN A METHOD FOR PRODUCING EPO 审中-公开
    生产EPO的方法中的过程控制

    公开(公告)号：US20120021441A1

    公开(公告)日：2012-01-26

    申请号：US13140190

    申请日：2009-12-07

    申请人： Franz-Rudolf Kunz ,  Florian Glaser ,  Wolfgang Wienand ,  Rudolf Hanko ,  Wilfried Eul ,  Dietmar Reichert

    发明人： Franz-Rudolf Kunz ,  Florian Glaser ,  Wolfgang Wienand ,  Rudolf Hanko ,  Wilfried Eul ,  Dietmar Reichert

    IPC分类号： G01N33/74 ,  G01N21/78

    CPC分类号： G01N33/746

    摘要： The invention relates to a method for determining the isoform composition of erythropoietin, comprising the following steps: a) isoelectrical focusing of a sample comprising erythropoietin in a gel over a pH range having a lower limit of 2.5 to 3.5 and an upper limit of 5 to 8, wherein the sample comprising erythropoietin originates from a culture supernatant of erythropoietin producing eukaryotic cells; b) transferring of the proteins comprised and separated in the gel to a membrane; c) verifying the erythropoietin bound to the membrane by specific antibodies; and to a method for in-process control of culture supernatants of erythropoietin producing eukaryotic cells during the fermentative production process.

    摘要翻译： 本发明涉及一种测定红细胞生成素的同种型组成的方法，包括以下步骤：a）将包含促红细胞生成素的样品在凝胶中的等电聚焦在pH范围内，其下限为2.5至3.5，上限为5至 8，其中包含促红细胞生成素的样品源自产生促红细胞生成素的真核细胞的培养上清液; b）将在凝胶中包含和分离的蛋白质转移到膜上; c）通过特异性抗体验证与该膜结合的促红细胞生成素; 以及在发酵生产过程中用于在产生促红细胞生成素的真核细胞的培养物上清液中进行过程控制的方法。