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公开(公告)号：US06506362B1
公开(公告)日：2003-01-14
申请号：US09832230
申请日：2001-04-10
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
IPC分类号： A61K3819
CPC分类号： C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US6121238A
公开(公告)日：2000-09-19
申请号：US244298
申请日：1999-02-03
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
CPC分类号： C07K14/524 , A61K38/00
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
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公开(公告)号：US06251864B1
公开(公告)日：2001-06-26
申请号：US09516704
申请日：2000-03-01
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
IPC分类号： A61K3800
CPC分类号： C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US5869451A
公开(公告)日：1999-02-09
申请号：US764640
申请日：1996-12-11
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randoph B. DePrince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randoph B. DePrince , Surekha Podduturi , Qun Yin
CPC分类号： C07K14/524 , A61K38/00
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
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公开(公告)号：US20090214489A1
公开(公告)日：2009-08-27
申请号：US12103377
申请日：2008-04-15
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US07091311B2
公开(公告)日：2006-08-15
申请号：US10083768
申请日：2002-02-27
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： C07K7/50
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
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公开(公告)号：US06465430B1
公开(公告)日：2002-10-15
申请号：US09549090
申请日：2000-04-13
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： A61K3800
摘要： Receptors are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 受体是结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US6083913A
公开(公告)日：2000-07-04
申请号：US973225
申请日：1997-12-04
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： A61K38/00 , A61P7/00 , C07K20060101 , C07K7/02 , C07K7/06 , C07K7/08 , C07K7/64 , C07K14/52 , A61K39/00 , C07K5/00 , C07K7/00
摘要： Receptors are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： PCT No.PCT / US96 / 09623 Sec。 371 1997年12月4日第 102（e）日期1997年12月4日PCT PCT 1996年6月7日PCT公布。 WO96 / 40750 PCT公开 日期1996年12月19日受体是结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US08227422B2
公开(公告)日：2012-07-24
申请号：US11610226
申请日：2006-12-13
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： C07K7/50
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US06309842B1
公开(公告)日：2001-10-30
申请号：US08977378
申请日：1997-11-24
申请人： William J. Dower , Christian M. Gates , Gregory L. Heinkel , Guy Lalonde , Larry C. Mattheakis , Christopher J. Paddon , Peter J. Schatz
发明人： William J. Dower , Christian M. Gates , Gregory L. Heinkel , Guy Lalonde , Larry C. Mattheakis , Christopher J. Paddon , Peter J. Schatz
IPC分类号： G01N3353
CPC分类号： G01N33/566 , C40B40/00 , G01N33/532 , G01N33/54306 , G01N2500/00
摘要： The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.
摘要翻译： 本发明提供了筛选具有所需性质，特别是激动，结合或拮抗细胞受体的能力的化合物的复合物文库的方法。 这些文库中的络合物包括被测化合物，记录化合物合成中至少一个步骤的标签，以及易受报道分子修饰的系链。 系链的修饰用于表示复合物含有具有所需性质的化合物。 可以对标签进行解码以显示合成这种化合物的至少一个步骤。
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