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公开(公告)号：US3965258A
公开(公告)日：1976-06-22
申请号：US568493
申请日：1975-04-16
CPC分类号： C12M25/06 , A61K39/12 , A61K39/255 , C12M23/50 , C12M27/14 , C12N2710/16334
摘要： Process for producing a live virus vaccine for the immunization of chickens against Marek's disease utilizing a multiplate machine.
摘要翻译： 使用多平面机器生产针对马立克氏病免疫鸡的活病毒疫苗的方法。
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公开(公告)号：US3933585A
公开(公告)日：1976-01-20
申请号：US475063
申请日：1974-05-31
CPC分类号： C12N7/00 , C12M23/50 , C12M25/06 , C12M27/14 , C12N2760/18464
摘要： A multiplate propagator for producing cells and vaccines having critical geometric properties such as ratio of plate diameter to internal tank diameter results in significantly increased yields at substantially reduced costs.
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公开(公告)号：US3976547A
公开(公告)日：1976-08-24
申请号：US525270
申请日：1974-11-19
CPC分类号： C12N5/0068 , C12N2533/10
摘要： Cell growth surfaces having controlled surface topography which permits the optimization of the fit between the cells and the growth surface. These surfaces may be constructed from sintered or sputtered titanium, glass, ceramic, plastic, or stainless steel, or may consist of a substrate having microspheres adhered to the surface thereof.
摘要翻译： 具有受控表面形貌的细胞生长表面，其允许优化细胞与生长表面之间的配合。 这些表面可以由烧结或溅射的钛，玻璃，陶瓷，塑料或不锈钢构成，或者可以由具有附着在其表面上的微球的基底组成。
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公开(公告)号：US4080258A
公开(公告)日：1978-03-21
申请号：US438082
申请日：1974-01-30
摘要： Production of cells and vaccines utilizing a multiplate propagator in which the fluid dynamics of the system can be controlled during the growth cycle and/or the harvesting conditions can be controlled by rapidly cooling the harvested vaccine or by using multiple harvests, with or without automated collection of the vaccine thereby producing cells and vaccines in significantly increased yields and at substantially reduced costs in comparison with presently utilized procedures.
摘要翻译： 使用多重传播器的细胞和疫苗的生产可以在生长周期和/或收获条件期间控制系统的流体动力学的方法可以通过快速冷却收获的疫苗或通过使用多个收获来控制，具有或不具有自动收集 从而与目前使用的方法相比，以显着增加的产量和显着降低的成本生产细胞和疫苗。
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公开(公告)号：US3959074A
公开(公告)日：1976-05-25
申请号：US530109
申请日：1974-12-06
CPC分类号： C12N5/0018
摘要： A process for the controlled manufacture of cells and vaccines in which reproducable real time quantitative assays are utilized to ascertain the physical and chemical state of the system, in order to more efficiently manage the system, so that cell sheet formation may be determined and the vaccine may be harvested at its maximum titre, thereby resulting in significantly increased yields and decreased production costs.
摘要翻译： 用于控制制造细胞和疫苗的方法，其中利用可重复的实时定量测定法来确定系统的物理和化学状态，以便更有效地管理系统，从而可以确定细胞片形成并且疫苗 可以以其最大滴定度收获，从而导致产量显着增加并降低生产成本。
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