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1.发明授权1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same 有权1,6-二氢-1,3,5,6-四氮杂 - 引入并三烯基的三环化合物和包含它们的药物组合物公开(公告)号：US07737279B2
公开(公告)日：2010-06-15
申请号：US11430215
申请日：2006-05-08
申请人： William J. Pitts , James Kempson , Junqing Guo , Jagabandhu Das , Charles M. Langevine , Steven H. Spergel , Scott Hunter Watterson
发明人： William J. Pitts , James Kempson , Junqing Guo , Jagabandhu Das , Charles M. Langevine , Steven H. Spergel , Scott Hunter Watterson
IPC分类号： C07D471/14 , A61K31/437 , A61K31/4375
CPC分类号： C07D471/14
摘要： The present invention provides for tricyclic compounds having the formula (I), wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的三环化合物，其中R 1，R 2，R 5，R 6，R 7和R 8如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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2.发明授权1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same 有权1,6-二氢-1,3,5,6-四氮杂 - 引入并三烯基的三环化合物和包含它们的药物组合物公开(公告)号：US08268855B2
公开(公告)日：2012-09-18
申请号：US12765932
申请日：2010-04-23
申请人： William J. Pitts , James Kempson , Junqing Guo , Jagabandhu Das , Charles M. Langevine , Steven H. Spergel , Scott Hunter Watterson
发明人： William J. Pitts , James Kempson , Junqing Guo , Jagabandhu Das , Charles M. Langevine , Steven H. Spergel , Scott Hunter Watterson
IPC分类号： C07D471/16 , C07D471/14 , A61K31/437
CPC分类号： C07D471/14
摘要： The present invention provides for tricyclic compounds having the formula (I), wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的三环化合物，其中R 1，R 2，R 5，R 6，R 7和R 8如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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3.发明申请1,6-DIHYDRO-1,3,5,6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 有权1,6-二氢-1,3,5,6-四氢异喹喔啉基异柠檬酸的三聚体化合物和包含其的药物组合物公开(公告)号：US20100210629A1
公开(公告)日：2010-08-19
申请号：US12765932
申请日：2010-04-23
申请人： William J. Pitts , James Kempson , Junqing Guo , Jagabandhu Das , Charles M. Langevine , Steven H. Spergel , Scott Hunter Watterson
发明人： William J. Pitts , James Kempson , Junqing Guo , Jagabandhu Das , Charles M. Langevine , Steven H. Spergel , Scott Hunter Watterson
IPC分类号： A61K31/551 , C07D471/14 , A61K31/437 , C07D413/10 , A61K31/5377 , C07D279/12 , A61K31/541 , C07D401/14 , A61K31/496 , C07D403/14 , A61K31/497 , C07D243/08 , A61P19/02 , A61P11/06 , A61P1/02 , A61P17/06
CPC分类号： C07D471/14
摘要： The present invention provides for tricyclic compounds having the formula (I), wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的三环化合物，其中R 1，R 2，R 5，R 6，R 7和R 8如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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4.发明申请PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES 有权吡咯烷酮JAK3抑制剂及其用于治疗炎症和自发性疾病的用途公开(公告)号：US20140011800A1
公开(公告)日：2014-01-09
申请号：US14005568
申请日：2012-03-16
申请人： Stephen T. Wrobleski , Jagabandhu Das , JIngwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , William J. Pitts , Steven H. Spergel , Hong Hu , Bingwei Vera Yang
发明人： Stephen T. Wrobleski , Jagabandhu Das , JIngwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , William J. Pitts , Steven H. Spergel , Hong Hu , Bingwei Vera Yang
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎症和自身免疫性疾病。
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5.发明授权Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases 有权吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途公开(公告)号：US08987268B2
公开(公告)日：2015-03-24
申请号：US14005568
申请日：2012-03-16
申请人： Stephen T. Wrobleski , Jagabandhu Das , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , William J. Pitts , Steven H. Spergel , Hong Wu , Bingwei Vera Yang
发明人： Stephen T. Wrobleski , Jagabandhu Das , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , William J. Pitts , Steven H. Spergel , Hong Wu , Bingwei Vera Yang
IPC分类号： C07D487/04 , C07D471/04 , A01N43/58 , A61K31/50
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎症和自身免疫性疾病。
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6.发明申请PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES 有权吡咯烷酮JAK3抑制剂及其用于治疗炎症和自发性疾病的用途公开(公告)号：US20140005146A1
公开(公告)日：2014-01-02
申请号：US14005572
申请日：2012-03-16
申请人： Stephen T. Wrobleski , Jagabandhu Das , Lidia M. Doweyko , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
发明人： Stephen T. Wrobleski , Jagabandhu Das , Lidia M. Doweyko , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
IPC分类号： C07D487/04 , C07F9/6561
CPC分类号： C07D487/04 , C07F9/6561
摘要： Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译： 公开了式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。
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7.发明授权Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases 有权吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途公开(公告)号：US09221826B2
公开(公告)日：2015-12-29
申请号：US14005572
申请日：2012-03-16
申请人： Stephen T. Wrobleski , Jagabandhu Das , Lidia M. Doweyko , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
发明人： Stephen T. Wrobleski , Jagabandhu Das , Lidia M. Doweyko , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
IPC分类号： A61K31/5025 , A61K31/675 , C07D487/04 , C07F9/6561
CPC分类号： C07D487/04 , C07F9/6561
摘要： Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译： 公开了式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。
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8.发明授权Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases 有权吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途公开(公告)号：US08921368B2
公开(公告)日：2014-12-30
申请号：US14005570
申请日：2012-03-16
申请人： Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
发明人： Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
IPC分类号： C07D487/04 , C07D471/04 , A01N43/58 , A61K31/50
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译： 公开了式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。
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9.发明申请PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES 有权吡咯烷酮JAK3抑制剂及其用于治疗炎症和自发性疾病的用途公开(公告)号：US20140011795A1
公开(公告)日：2014-01-09
申请号：US14005570
申请日：2012-03-16
申请人： Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
发明人： Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译： 公开了式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。
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10.发明申请1,6-Dihydro-1,3,5,6-Tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same 有权1,6-二氢-1,3,5,6-四氮杂 - 引入并三烯基三环化合物和包含它们的药物组合物公开(公告)号：US20060270654A1
公开(公告)日：2006-11-30
申请号：US11430215
申请日：2006-05-08
申请人： William Pitts , James Kempson , Junqing Guo , Jagabandhu Das , Charles Langevine , Steven Spergel , Scott Watterson
发明人： William Pitts , James Kempson , Junqing Guo , Jagabandhu Das , Charles Langevine , Steven Spergel , Scott Watterson
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/14
CPC分类号： C07D471/14
摘要： The present invention provides for tricyclic compounds having the formula (I), wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
摘要翻译： 本发明提供具有式（I）的三环化合物，其中R 1，R 2，R 5，R 6， R＆lt; 7＆gt;和＆lt; 8＆gt;如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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