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1.PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES 有权
标题翻译: 吡咯烷酮JAK3抑制剂及其用于治疗炎症和自发性疾病的用途公开(公告)号:US20140011800A1
公开(公告)日:2014-01-09
申请号:US14005568
申请日:2012-03-16
申请人: Stephen T. Wrobleski , Jagabandhu Das , JIngwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , William J. Pitts , Steven H. Spergel , Hong Hu , Bingwei Vera Yang
发明人: Stephen T. Wrobleski , Jagabandhu Das , JIngwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , William J. Pitts , Steven H. Spergel , Hong Hu , Bingwei Vera Yang
IPC分类号: C07D487/04
CPC分类号: C07D487/04 , C07D519/00
摘要: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制JAK3的酪氨酸激酶活性,从而使其可用于治疗炎症和自身免疫性疾病。
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2.Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases 有权
标题翻译: 吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途公开(公告)号:US08987268B2
公开(公告)日:2015-03-24
申请号:US14005568
申请日:2012-03-16
申请人: Stephen T. Wrobleski , Jagabandhu Das , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , William J. Pitts , Steven H. Spergel , Hong Wu , Bingwei Vera Yang
发明人: Stephen T. Wrobleski , Jagabandhu Das , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , William J. Pitts , Steven H. Spergel , Hong Wu , Bingwei Vera Yang
IPC分类号: C07D487/04 , C07D471/04 , A01N43/58 , A61K31/50
CPC分类号: C07D487/04 , C07D519/00
摘要: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制JAK3的酪氨酸激酶活性,从而使其可用于治疗炎症和自身免疫性疾病。
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3.Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases 有权
标题翻译: 吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途公开(公告)号:US08921368B2
公开(公告)日:2014-12-30
申请号:US14005570
申请日:2012-03-16
申请人: Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
发明人: Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
IPC分类号: C07D487/04 , C07D471/04 , A01N43/58 , A61K31/50
CPC分类号: C07D487/04 , C07D471/04 , C07D519/00
摘要: Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译: 公开了式(I)的化合物及其药学上可接受的盐。 式(I)化合物抑制JAK3的酪氨酸激酶活性,从而使其可用于治疗炎性和自身免疫性疾病。
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4.PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES 有权
标题翻译: 吡咯烷酮JAK3抑制剂及其用于治疗炎症和自发性疾病的用途公开(公告)号:US20140011795A1
公开(公告)日:2014-01-09
申请号:US14005570
申请日:2012-03-16
申请人: Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
发明人: Stephen T. Wrobleski , Gregory D. Brown , Lidia M. Doweyko , Jingwu Duan , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Zhonghui Lu , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
IPC分类号: C07D487/04 , C07D471/04
CPC分类号: C07D487/04 , C07D471/04 , C07D519/00
摘要: Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译: 公开了式(I)的化合物及其药学上可接受的盐。 式(I)化合物抑制JAK3的酪氨酸激酶活性,从而使其可用于治疗炎性和自身免疫性疾病。
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5.PYRROLOPYRIDAZINE JAK3 INHIBITORS AND THEIR USE FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES 有权
标题翻译: 吡咯烷酮JAK3抑制剂及其用于治疗炎症和自发性疾病的用途公开(公告)号:US20140005146A1
公开(公告)日:2014-01-02
申请号:US14005572
申请日:2012-03-16
申请人: Stephen T. Wrobleski , Jagabandhu Das , Lidia M. Doweyko , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
发明人: Stephen T. Wrobleski , Jagabandhu Das , Lidia M. Doweyko , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
IPC分类号: C07D487/04 , C07F9/6561
CPC分类号: C07D487/04 , C07F9/6561
摘要: Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译: 公开了式(I)的化合物及其药学上可接受的盐。 式(I)化合物抑制JAK3的酪氨酸激酶活性,从而使其可用于治疗炎性和自身免疫性疾病。
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6.Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases 有权
标题翻译: 吡咯并哒嗪JAK3抑制剂及其用于治疗炎症和自身免疫疾病的用途公开(公告)号:US09221826B2
公开(公告)日:2015-12-29
申请号:US14005572
申请日:2012-03-16
申请人: Stephen T. Wrobleski , Jagabandhu Das , Lidia M. Doweyko , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
发明人: Stephen T. Wrobleski , Jagabandhu Das , Lidia M. Doweyko , Junqing Guo , John Hynes , Bin Jiang , James Kempson , Shuqun Lin , Steven H. Spergel , John S. Tokarski , Hong Wu , Bingwei Vera Yang
IPC分类号: A61K31/5025 , A61K31/675 , C07D487/04 , C07F9/6561
CPC分类号: C07D487/04 , C07F9/6561
摘要: Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要翻译: 公开了式(I)的化合物及其药学上可接受的盐。 式(I)化合物抑制JAK3的酪氨酸激酶活性,从而使其可用于治疗炎性和自身免疫性疾病。
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公开(公告)号:US20080171741A1
公开(公告)日:2008-07-17
申请号:US11923760
申请日:2007-10-25
申请人: Stephen T. Wrobleski , Jagabandhu Das , T.G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin
发明人: Stephen T. Wrobleski , Jagabandhu Das , T.G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin
IPC分类号: A61K31/5377 , C07D261/06 , C07D271/10 , C07D271/06 , C07D211/86 , C07D253/06 , C07D333/06 , C07D413/10 , A61P29/00 , C07D413/06 , A61K31/42 , A61K31/4245 , A61K31/4412 , A61K31/53 , A61K31/381
CPC分类号: C07D261/18 , C07C237/42 , C07C2601/02 , C07D207/456 , C07D209/08 , C07D209/42 , C07D211/62 , C07D213/81 , C07D213/82 , C07D231/56 , C07D233/90 , C07D235/06 , C07D249/06 , C07D271/06 , C07D271/10 , C07D275/03 , C07D295/192 , C07D307/68 , C07D333/38 , C07D409/04 , C07D487/04 , C07D513/04
摘要: A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.
摘要翻译: 式I化合物及其对映异构体,非对映异构体和药学上可接受的盐。 还公开了含有式I化合物的药物组合物,以及治疗与p38激酶活性相关的病症的方法。
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8.Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors 有权
标题翻译: 用作激酶抑制剂的苯基苯胺取代的双环化合物公开(公告)号:US07642257B2
公开(公告)日:2010-01-05
申请号:US12047550
申请日:2008-03-13
申请人: Jagabandhu Das , John Hynes , Katerina Leftheris , Shuqun Lin , Stephen T. Wrobleski , Hong Wu
发明人: Jagabandhu Das , John Hynes , Katerina Leftheris , Shuqun Lin , Stephen T. Wrobleski , Hong Wu
IPC分类号: C07D487/04 , A61K31/4985 , A61P19/02
CPC分类号: C07D471/04 , C07D487/04 , C07D495/04
摘要: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.
摘要翻译: 具有式(I)的化合物及其药学上可接受的盐,前药和溶剂合物可用作激酶抑制剂,其中R,R1,R2,R5,R6a,R6b,J,K,X和Z如 规范。
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9.Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors 有权
标题翻译: 用作激酶抑制剂的苯基苯胺取代的双环化合物公开(公告)号:US07419978B2
公开(公告)日:2008-09-02
申请号:US10970420
申请日:2004-10-21
申请人: Jagabandhu Das , John Hynes , Katerina Leftheris , Shuqun Lin , Stephen T. Wrobleski , Hong Wu
发明人: Jagabandhu Das , John Hynes , Katerina Leftheris , Shuqun Lin , Stephen T. Wrobleski , Hong Wu
IPC分类号: C07D487/04 , C07D487/14 , A61K31/53 , A61P19/02 , A61P19/10
CPC分类号: C07D471/04 , C07D487/04 , C07D495/04
摘要: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.
摘要翻译: 具有式(I)的化合物及其药学上可接受的盐,前药和溶剂合物可用作激酶抑制剂,其中R 1,R 2,R 2,R 2, R 5,R 6a,R 6b,J,K,X和Z如说明书中所述。
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公开(公告)号:US20110160207A1
公开(公告)日:2011-06-30
申请号:US13038488
申请日:2011-03-02
申请人: Stephen T. Wrobleski , Jagabandhu Das , T.G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin
发明人: Stephen T. Wrobleski , Jagabandhu Das , T.G. Murali Dhar , Alaric J. Dyckman , John Hynes , Katerina Leftheris , James Lin , Shuqun Lin
IPC分类号: A61K31/5377 , C07D261/18 , A61K31/42 , C07D271/10 , A61K31/4245 , C07D271/06 , C07D213/81 , A61K31/4412 , C07D487/04 , A61K31/53 , C07D513/04 , A61K31/519 , C07D233/90 , A61K31/4164 , C07D249/06 , A61K31/4192 , C07D403/12 , C07D295/195 , A61K31/495 , C07D211/62 , A61K31/445 , A61K31/407 , A61K31/44 , C07D333/38 , A61K31/381 , C07D413/14 , C07D409/04 , A61K31/4436 , C07D413/10 , C07D209/08 , C07D413/06 , A61P11/00 , A61P11/06 , A61P29/00 , A61P11/08 , A61P3/10 , A61P1/00 , A61P17/06 , A61P19/10 , A61P37/06 , A61P9/10 , A61P35/00 , A61P19/02
CPC分类号: C07D261/18 , C07C237/42 , C07C2601/02 , C07D207/456 , C07D209/08 , C07D209/42 , C07D211/62 , C07D213/81 , C07D213/82 , C07D231/56 , C07D233/90 , C07D235/06 , C07D249/06 , C07D271/06 , C07D271/10 , C07D275/03 , C07D295/192 , C07D307/68 , C07D333/38 , C07D409/04 , C07D487/04 , C07D513/04
摘要: A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.
摘要翻译: 式I化合物及其对映异构体,非对映异构体和药学上可接受的盐。 还公开了含有式I化合物的药物组合物,以及治疗与p38激酶活性相关的病症的方法。
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