公开(公告)号：US07210966B2

公开(公告)日：2007-05-01

申请号：US10889771

申请日：2004-07-12

申请人： William J. Taylor ,  Shawn D. Knowles ,  John C. Olson

发明人： William J. Taylor ,  Shawn D. Knowles ,  John C. Olson

IPC分类号： H01R13/66

CPC分类号： A61N1/05 ,  A61N1/3718 ,  A61N1/3754 ,  H01G4/35 ,  H01R13/7197 ,  H01R2201/12

摘要： An improved multi-polar feedthrough assembly employs a particular metallic ferrule material for improved dimensional stability during initial fabrication and sustained hermetic operation. In one aspect, the disclosure relates to implantable medical devices (IMDs) including an IMD enclosure fabricated with grade 2 titanium and having a ferrule material fabricated with grade 4 titanium or grade 5 titanium. In one form, the multi-polar feedthrough assembly includes a filtered feedthrough array (e.g., employing capacitive filters coupled to the electrically conductive pins or serpentine conductors of the array). According to another aspect, the improved multi-polar feedthrough assembly incorporates additional pins, thus increasing the footprint of the assembly, and the additional pins provide analog electrical communication between operative circuitry inside an IMD and analog components external to the IMD.

摘要翻译： 改进的多极馈通组件采用特定的金属套圈材料，用于在初始制造和持续密封操作期间改善尺寸稳定性。 在一个方面，本公开涉及可植入医疗装置（IMD），其包括用等级2钛制成的具有由4级钛或5级钛制成的套圈材料的IMD外壳。 在一种形式中，多极馈通组件包括滤波的馈通阵列（例如，使用耦合到阵列的导电引脚或蛇形导体的电容滤波器）。 根据另一方面，改进的多极馈通组件包括额外的引脚，因此增加了组件的占地面积，并且附加引脚在IMD内的操作电路和IMD外部的模拟组件之间提供模拟电气通信。

公开(公告)号：US08160707B2

公开(公告)日：2012-04-17

申请号：US11343106

申请日：2006-01-30

申请人： Rajesh V. Iyer ,  Daniel J. Koch ,  Simon E. Goldman ,  Shawn D. Knowles ,  William J. Taylor ,  Joyce K. Yamamoto ,  Gregory J. Haubrich ,  Michael Nowak ,  David Nghiem ,  Roger L. Hubing ,  Len D. Twetan

发明人： Rajesh V. Iyer ,  Daniel J. Koch ,  Simon E. Goldman ,  Shawn D. Knowles ,  William J. Taylor ,  Joyce K. Yamamoto ,  Gregory J. Haubrich ,  Michael Nowak ,  David Nghiem ,  Roger L. Hubing ,  Len D. Twetan

IPC分类号： A61N1/00 ,  H03H7/00

CPC分类号： A61N1/3754 ,  A61N1/3718

摘要： An implantable medical device is provided including a housing, an external circuit element extending outwardly from the housing, an internal circuit enclosed by the housing, a feedthrough array disposed along the housing having at least one filtered feedthrough and at least one unfiltered feedthrough, wherein the unfiltered feedthrough is adapted for connection to the outwardly extending circuit element; and including means for minimizing electromagnetic coupling between the filtered feedthrough and the unfiltered feedthrough.

摘要翻译： 提供了可植入医疗装置，其包括壳体，从壳体向外延伸的外部电路元件，由壳体包围的内部电路，沿壳体设置的馈通阵列，具有至少一个滤波的馈通和至少一个未滤波的馈通，其中， 未过滤的馈通适于连接到向外延伸的电路元件; 并且包括用于最小化经滤波的馈通和未过滤的馈通之间的电磁耦合的装置。

公开(公告)号：US07748093B2

公开(公告)日：2010-07-06

申请号：US11872452

申请日：2007-10-15

申请人： Rajesh V. Iyer ,  Susan A. Tettemer ,  John P. Tardiff ,  Shawn D. Knowles

发明人： Rajesh V. Iyer ,  Susan A. Tettemer ,  John P. Tardiff ,  Shawn D. Knowles

IPC分类号： H01G7/00

CPC分类号： H01G4/242 ,  H01G2/106 ,  H01G4/35 ,  Y10T29/42 ,  Y10T29/435 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49078 ,  Y10T29/4913 ,  Y10T29/49165 ,  Y10T29/49171 ,  Y10T29/49176

摘要： A filtered feedthrough assembly having at least one terminal pin therethrough is provided. The feedthrough assembly comprises a ferrule having a cavity therethrough for receiving the terminal pin, and insulating structure having an upper surface. The insulating structure is disposed within the cavity and around the terminal pin for electrically isolating the pin from the ferrule. A capacitor is disposed around the pin and electrically coupled thereto. The capacitor has a lower surface that is disposed proximate the upper surface, and at least one washer is disposed between the upper surface and the lower surface. To attach the capacitor to the insulating structure, a body of epoxy is substantially confined between the upper surface and the lower surface by the ferrule, the insulating structure, the capacitor, and the at least one washer.

摘要翻译： 提供了具有穿过其中的至少一个端子销的经滤波的馈通组件。 馈通组件包括具有穿过其的用于接收端子销的空腔的套圈以及具有上表面的绝缘结构。 绝缘结构设置在空腔内并且围绕端子销以将引脚与套圈电隔离。 电容器设置在销周围并与其电耦合。 电容器具有靠近上表面设置的下表面，并且至少一个垫圈设置在上表面和下表面之间。 为了将电容器附接到绝缘结构，环氧树脂体通过套圈，绝缘结构，电容器和至少一个垫圈基本上限制在上表面和下表面之间。

公开(公告)号：US07590450B2

公开(公告)日：2009-09-15

申请号：US11343174

申请日：2006-01-30

申请人： Rajesh V. Iyer ,  Shawn D. Knowles

发明人： Rajesh V. Iyer ,  Shawn D. Knowles

IPC分类号： A61N1/00

CPC分类号： A61N1/3754

摘要： An electronic module assembly for an implantable medical device includes a non-conductive block having an opening for accepting a feedthrough conductor. The block has opposite first and second ends and opposite first and second sides. A bond pad is located on the first end of the block for electrical connection to a feedthrough conductor, and the bond pad extends to the first side of the block to provide an electrical connection region there.

摘要翻译： 用于可植入医疗装置的电子模块组件包括具有用于接受馈通导体的开口的非导电块。 该块具有相对的第一和第二端以及相对的第一和第二侧。 接合焊盘位于块的第一端上，用于电连接到馈通导体，并且接合焊盘延伸到块的第一侧以在其中提供电连接区域。

公开(公告)号：US08229570B2

公开(公告)日：2012-07-24

申请号：US11343059

申请日：2006-01-30

申请人： Lea A. Nygren ,  Shawn D. Knowles

发明人： Lea A. Nygren ,  Shawn D. Knowles

IPC分类号： A61N1/00 ,  A61B5/04

CPC分类号： A61N1/056 ,  A61B5/042 ,  A61N1/3716

摘要： An implantable medical electrode comprising an electrode substrate having an exterior surface, and a zirconium nitride coating disposed over the exterior surface.

摘要翻译： 一种可植入医疗电极，包括具有外表面的电极基底和设置在外表面上的氮化锆涂层。

公开(公告)号：US07706124B2

公开(公告)日：2010-04-27

申请号：US12360882

申请日：2009-01-28

申请人： Jennifer J. Zhao ,  Micah A. Litow ,  Rajesh Iyer ,  Dawit Y. Belete ,  Simon E. Goldman ,  Shawn D. Knowles

发明人： Jennifer J. Zhao ,  Micah A. Litow ,  Rajesh Iyer ,  Dawit Y. Belete ,  Simon E. Goldman ,  Shawn D. Knowles

IPC分类号： H01G4/236 ,  H01G4/228 ,  A61N1/00

CPC分类号： H01G4/35 ,  A61N1/3754 ,  H01G2/10 ,  Y10T29/435 ,  Y10T29/49002

摘要： A filtering capacitor feedthrough assembly for an implantable active medical device is disclosed. The filtering capacitor feedthrough assembly includes a capacitor having an aperture, the capacitor is electrically grounded to an electrically conductive feedthrough ferrule or housing of the implantable active medical device. A terminal pin extends into the aperture and an electrically conductive continuous coil is disposed within the aperture and between the terminal pin and the capacitor. The electrically conductive continuous coil mechanically secures and electrically couples the terminal pin to the capacitor.

摘要翻译： 公开了一种用于可植入有源医疗装置的滤波电容器馈通组件。 滤波电容器馈通组件包括具有孔的电容器，电容器电接地到可植入有源医疗装置的导电馈通插芯或壳体。 端子销延伸到孔中，并且导电连续线圈设置在孔内并且在端子引脚和电容器之间。 导电连续线圈将端子引脚机械地固定和电耦合到电容器。

公开(公告)号：US06866886B2

公开(公告)日：2005-03-15

申请号：US10406766

申请日：2003-04-02

申请人： Shawn D. Knowles ,  David J. Senor ,  Steven V. Forbes ,  Roger N. Johnson ,  Glenn W. Hollenberg

发明人： Shawn D. Knowles ,  David J. Senor ,  Steven V. Forbes ,  Roger N. Johnson ,  Glenn W. Hollenberg

IPC分类号： C23C10/04 ,  C23C10/06 ,  C23C14/04 ,  C23C14/24 ,  C23C14/26 ,  C23C14/58 ,  B05D7/22

CPC分类号： C23C14/26 ,  C23C10/06 ,  C23C14/046 ,  C23C14/24 ,  C23C14/5893 ,  Y10S118/10 ,  Y10S118/13

摘要： A method for forming a diffusion coating on the interior of surface of a hollow object wherein a filament, extending through a hollow object and adjacent to the interior surface of the object, is provided, with a coating material, in a vacuum. An electrical current is then applied to the filament to resistively heat the filament to a temperature sufficient to transfer the coating material from the filament to the interior surface of the object. The filament is electrically isolated from the object while the filament is being resistively heated. Preferably, the filament is provided as a tungsten filament or molybdenum filament. Preferably, the coating materials are selected from the group consisting of Ag, Al, As, Au, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Dy, Er, Eu, Fe, Ga, Ge, Hg, In, K, Li, Mg, Mn, Na, Ni P, Pb, Pd, Pr, S, Sb, Sc, Se, Si, Sn, Sr, Te, Tl, Y, Yb, Zn, and combinations thereof. The invention additionally allows for the formation of nitrides, hydrides, or carbides of all the possible coating materials, where such compounds exist, by providing a partial pressure of nitrogen, hydrogen, hydrocarbons, or combination thereof, within the vacuum.

摘要翻译： 一种在中空物体的表面内部形成扩散涂层的方法，其中通过中空物体延伸并与物体的内表面相邻的细丝在真空中被提供有涂层材料。 然后将电流施加到灯丝​​上以将灯丝电阻加热到足以将涂层材料从灯丝转移到物体的内表面的温度。 当灯丝被电阻加热时，灯丝与物体电隔离。 优选地，丝被提供为钨丝或钼丝。 优选地，涂层材料选自Ag，Al，As，Au，Ba，Be，Bi，Ca，Cd，Co，Cr，Cu，Dy，Er，Eu，Fe，Ga，Ge，Hg， In，K，Li，Mg，Mn，Na，Ni P，Pb，Pd，Pr，S，Sb，Sc，Se，Si，Sn，Sr，Te，Tl，Y，Yb，Zn及其组合。 本发明还允许通过在真空中提供氮，氢，烃或其组合的分压，形成所有可能的涂覆材料的氮化物，氢化物或碳化物，其中存在这些化合物。

公开(公告)号：US08290557B2

公开(公告)日：2012-10-16

申请号：US11955025

申请日：2007-12-12

申请人： Timothy J. Davis ,  Jonathan P. Roberts ,  James D. Reinke ,  Jonathan L. Kuhn ,  Shawn D. Knowles

发明人： Timothy J. Davis ,  Jonathan P. Roberts ,  James D. Reinke ,  Jonathan L. Kuhn ,  Shawn D. Knowles

IPC分类号： A61B5/1455 ,  A61B5/02

CPC分类号： A61B5/14542 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6846 ,  A61B2562/0233 ,  A61B2562/043

摘要： An implantable medical device includes a hermetically sealed housing and a first light emitting diode (LED) enclosed within the housing configured to detect light corresponding to a selected light wavelength. A conductive element extends from the LED for carrying a current signal corresponding to the light detected by the LED, the intensity of the detected light being correlated to a change in a physiological condition in a body fluid volume or a tissue volume proximate the LED.

摘要翻译： 可植入医疗装置包括密封的壳体和封装在壳体内的第一发光二极管（LED），其被配置为检测对应于所选择的光波长的光。 导电元件从LED延伸，用于承载对应于由LED检测到的光的电流信号，检测到的光的强度与体液体积或接近LED的组织体积的生理状态的变化相关。

公开(公告)号：US20080198530A1

公开(公告)日：2008-08-21

申请号：US11675880

申请日：2007-02-16

申请人： Jennifer J. Zhao ,  Micah A. Litow ,  Rajesh Iyer ,  Dawit Y. Belete ,  Simon E. Goldman ,  Shawn D. Knowles

发明人： Jennifer J. Zhao ,  Micah A. Litow ,  Rajesh Iyer ,  Dawit Y. Belete ,  Simon E. Goldman ,  Shawn D. Knowles

IPC分类号： H01G4/236 ,  A61N1/375

CPC分类号： H01G4/35 ,  A61N1/3754 ,  H01G2/10 ,  Y10T29/435 ,  Y10T29/49002

摘要： A filtering capacitor feedthrough assembly for an implantable active medical device is disclosed. The filtering capacitor feedthrough assembly includes a capacitor having an aperture, the capacitor is electrically grounded to an electrically conductive feedthrough ferrule or housing of the implantable active medical device. A terminal pin extends into the aperture and an electrically conductive continuous coil is disposed within the aperture and between the terminal pin and the capacitor. The electrically conductive continuous coil mechanically secures and electrically couples the terminal pin to the capacitor.

摘要翻译： 公开了一种用于可植入有源医疗装置的滤波电容器馈通组件。 滤波电容器馈通组件包括具有孔的电容器，电容器电接地到可植入有源医疗装置的导电馈通插芯或壳体。 端子销延伸到孔中，并且导电连续线圈设置在孔内并且在端子引脚和电容器之间。 导电连续线圈将端子引脚机械地固定和电耦合到电容器。

公开(公告)号：US07281305B1

公开(公告)日：2007-10-16

申请号：US11278291

申请日：2006-03-31

申请人： Rajesh V. Iyer ,  Susan A. Tettemer ,  John P Tardiff ,  Shawn D. Knowles

发明人： Rajesh V. Iyer ,  Susan A. Tettemer ,  John P Tardiff ,  Shawn D. Knowles

IPC分类号： H01G7/00

CPC分类号： H01G4/242 ,  H01G2/106 ,  H01G4/35 ,  Y10T29/42 ,  Y10T29/435 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49078 ,  Y10T29/4913 ,  Y10T29/49165 ,  Y10T29/49171 ,  Y10T29/49176

摘要： A method for attaching a capacitor to the feedthrough assembly of a medical device having a terminal pin comprises threading a first washer over the terminal pin, and placing a body of epoxy in contact with the first washer. The capacitor is positioned over the terminal pin such that the first washer and the body of epoxy are between the lower surface of the capacitor and a support surface. The body of epoxy is cured to couple the capacitor to the insulating structure. During curing, the body of epoxy is substantially confined between the upper surface and the lower surface by the ferrule, the insulating structure, the capacitor, and the first washer.

摘要翻译： 用于将电容器附接到具有端子销的医疗装置的馈通组件的方法包括：在端子销上穿过第一垫圈，并且将环氧体与第一垫圈接触。 电容器位于端子销上方，使得第一垫圈和环氧树脂体位于电容器的下表面和支撑表面之间。 环氧树脂体被固化以将电容器耦合到绝缘结构。 在固化期间，环氧树脂体通过套圈，绝缘结构，电容器和第一垫圈基本上限制在上表面和下表面之间。