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1.发明授权Monoclonal antibodies that specifically bind somatotropin binding proteins but not to corresponding somatotropin receptors and methods of use in immunoassays 失效特异性结合生长激素结合蛋白而不是相应的生长激素受体的单克隆抗体和免疫测定中使用的方法
公开(公告)号：US5439795A
公开(公告)日：1995-08-08
申请号：US473086
申请日：1990-01-31
IPC分类号： A61K39/395 , A61K38/00 , A61K51/00 , A61P5/00 , C07K1/22 , C07K14/00 , C07K16/00 , C07K16/28 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C07K16/18
CPC分类号： C07K16/2869 , A61K38/00
摘要： The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding somatotropin receptors. The antibodies may also be used to assay the level of somatotropin binding protein of animals.
摘要翻译： 本发明涉及特异性结合动物生长激素结合蛋白但不与相应生长激素受体结合的抗体，特别是单克隆抗体。 抗体也可用于测定动物生长激素结合蛋白的水平。
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公开(公告)号：US5210180A
公开(公告)日：1993-05-11
申请号：US427669
申请日：1989-10-27
申请人： Bosco S. Wang , Ian C. Hart , Hong-Ming Shieh
发明人： Bosco S. Wang , Ian C. Hart , Hong-Ming Shieh
IPC分类号： C12N15/02 , A61K38/00 , A61K38/27 , A61K39/395 , C07K7/06 , C07K7/08 , C07K14/575 , C07K14/61 , C07K16/00 , C07K16/26 , C12N5/10 , C12P21/08 , C12R1/91
CPC分类号： C07K16/26 , C07K14/61 , A61K38/00 , C07K2317/34
摘要： This invention is directed to peptide fragments of porcine somatotropin (pST) which are used to generate epitope-specific anti-pST antibodies. When such antibodies are administered with pST to warm-blooded animals, the growth enhancing activity of pST is potentiated.
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3.发明授权
公开(公告)号：US5202251A
公开(公告)日：1993-04-13
申请号：US560677
申请日：1990-08-03
摘要： This invention is directed to the generation of hybridomas and the monocot-specific monoclonal antibodies prepared from those hybridomas against the acetohydroxyacid synthase enzyme. The monoclonal antibodies are useful to isolate and purify the enzyme. The invention is also directed to peptides corresponding to fragments of the enzyme which then are used to generate the monoclonal antibodies.
摘要翻译： 本发明涉及从针对乙酰羟酸合酶的那些杂交瘤制备的杂交瘤和单子叶特异性单克隆抗体的产生。 单克隆抗体可用于分离和纯化酶。 本发明还涉及对应于酶的片段的肽，然后用于产生单克隆抗体。
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4.发明授权Biologically active porcine somatotropin polypeptides and methods of using the same 失效生物活性猪生长激素多肽及其使用方法
公开(公告)号：US5338836A
公开(公告)日：1994-08-16
申请号：US922523
申请日：1992-07-29
IPC分类号： A23K1/165 , A61K38/00 , A61K38/27 , A61K39/00 , A61P3/00 , C07K14/00 , C07K14/575 , C07K14/61 , C07K16/00 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , A61K37/02 , A01N37/18 , A61K37/36 , C07K7/00
摘要： An isolated polypeptide corresponding to the epitope of porcine somatotropin is provided by this invention as well as methods of enhancing the growth of an animal by administering to the animal this polypeptide in compositions.
摘要翻译： 通过本发明提供了对应于猪生长激素表位的分离的多肽，以及通过在组合物中向动物施用该多肽来增强动物生长的方法。
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公开(公告)号：US4965284A
公开(公告)日：1990-10-23
申请号：US341862
申请日：1989-04-25
IPC分类号： A61K31/38 , A61K31/381 , A61K31/382 , A61P7/00 , A61P37/04 , C07D333/76 , C07D335/12 , C07D409/00
CPC分类号： C07D333/76 , C07D335/12
摘要： This disclosure described novel derivatives of dibenzothiophene, dibenzothiophene sulfoxide, dibenzothiophene sulfone, thioxanthene, thioxanthene sulfoxide and thioxanthene sulfone which are active as modulators of the mammalian immune response system.
摘要翻译： 本公开描述了作为哺乳动物免疫应答系统的调节剂的二苯并噻吩，二苯并噻吩亚砜，二苯并噻吩砜，噻吨酮，噻吨酮亚砜和噻吨酮砜的新衍生物。
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