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1.发明授权Monoclonal antibodies that specifically bind somatotropin binding proteins but not to corresponding somatotropin receptors and methods of use in immunoassays 失效特异性结合生长激素结合蛋白而不是相应的生长激素受体的单克隆抗体和免疫测定中使用的方法
公开(公告)号：US5439795A
公开(公告)日：1995-08-08
申请号：US473086
申请日：1990-01-31
IPC分类号： A61K39/395 , A61K38/00 , A61K51/00 , A61P5/00 , C07K1/22 , C07K14/00 , C07K16/00 , C07K16/28 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C07K16/18
CPC分类号： C07K16/2869 , A61K38/00
摘要： The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding somatotropin receptors. The antibodies may also be used to assay the level of somatotropin binding protein of animals.
摘要翻译： 本发明涉及特异性结合动物生长激素结合蛋白但不与相应生长激素受体结合的抗体，特别是单克隆抗体。 抗体也可用于测定动物生长激素结合蛋白的水平。
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2.发明授权Balloon catheter systems for delivery of dry drug delivery vesicles to a vessel in the body 有权用于将干性药物递送囊泡递送至体内血管的气囊导管系统公开(公告)号：US08696644B2
公开(公告)日：2014-04-15
申请号：US12982760
申请日：2010-12-30
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61K9/107 , A61K31/00 , A61K31/436 , A61L29/146 , A61L29/16 , A61L2300/416 , A61L2300/626 , A61M25/10 , A61M25/1011 , A61M25/1018 , A61M25/10182 , A61M25/10185 , A61M25/10187 , A61M2025/1013 , A61M2025/105 , A61M2025/1075
摘要： Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.
摘要翻译： 用于将雷帕霉素和其它疏水化合物气球递送至血管壁的装置和方法。 球囊导管，例如用于球囊血管成形术的导管，通过添加设置在球囊或导管内的适当位置处的干胶束储库来改变。 储存器可以安装在血管成形术球囊内，在与血管成形术球囊连通的腔内，无论是松散的还是包装的粉末，或作为薄膜包衣。 当将用于使气囊充气的水溶液注入导管时，胶束制剂被重构并且胶束被起动。 当球囊内的加压流体通过气球的壁泄漏时，胶束被注入到球囊周围的组织中。
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3.发明申请Balloon Catheter Systems for Delivery of Dry Drug Delivery Vesicles to a Vessel in the Body 有权用于将干性药物递送囊泡递送至身体中的血管的气球导管系统公开(公告)号：US20110166547A1
公开(公告)日：2011-07-07
申请号：US12982760
申请日：2010-12-30
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61K9/107 , A61K31/00 , A61K31/436 , A61L29/146 , A61L29/16 , A61L2300/416 , A61L2300/626 , A61M25/10 , A61M25/1011 , A61M25/1018 , A61M25/10182 , A61M25/10185 , A61M25/10187 , A61M2025/1013 , A61M2025/105 , A61M2025/1075
摘要： Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.
摘要翻译： 用于将雷帕霉素和其它疏水化合物气球递送至血管壁的装置和方法。 球囊导管，例如用于球囊血管成形术的导管，通过添加设置在球囊或导管内的适当位置处的干胶束储库来改变。 储存器可以安装在血管成形术球囊内，在与血管成形术球囊连通的腔内，无论是松散的还是包装的粉末，或作为薄膜包衣。 当将用于使气囊充气的水溶液注入导管时，胶束制剂被重构并且胶束被起动。 当球囊内的加压流体通过气球的壁泄漏时，胶束被注入到球囊周围的组织中。
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公开(公告)号：US20090220564A1
公开(公告)日：2009-09-03
申请号：US12063792
申请日：2006-08-18
IPC分类号： A61F2/00 , A61K39/395
CPC分类号： C07K16/00 , C07K16/468 , C07K2317/626
摘要： The present disclosure provides methods and compositions for treating coronary tissue damaged as a result of a cardiac disorder such as ischemia, acute myocardial infarction, vulnerable plaques, or reperfusion injury. Specifically, the cardiac disorder is treated using a multivalent molecule that is specific for a marker located, in or near the damaged coronary tissue and a marker located on a target cell (e.g., a stem cell). The multivalent molecule may be administered by intravenous injection, intra-arterial catheter, intramyocardial injection, or implantable device (e.g, stent).
摘要翻译： 本公开提供用于治疗由于心脏病，如局部缺血，急性心肌梗塞，易发生斑块或再灌注损伤而损伤的冠状动脉组织的方法和组合物。 具体地，使用对位于损伤的冠状动脉组织中或其附近的标记和位于靶细胞（例如干细胞）上的标记的标记特异的多价分子来治疗心脏病。 多价分子可以通过静脉注射，动脉内导管，心肌内注射或可植入装置（例如，支架）来施用。
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公开(公告)号：US06342499B1
公开(公告)日：2002-01-29
申请号：US09352507
申请日：1999-07-12
IPC分类号： A01N4354
摘要： The present invention provides a method to control parasitic and saprophagous mites on beneficial insects such as honeybees via the application of a parasiticidally or saprophagouscidally effective amount of a mitochondrial electron transport inhibitor or a pyrimidine compound of formula I.
摘要翻译： 本发明提供了一种通过施用杀虫剂或杀真菌有效量的线粒体电子传递抑制剂或式I的嘧啶化合物来控制有益昆虫例如蜜蜂的寄生虫和螨虫螨的方法。
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公开(公告)号：US06204283B1
公开(公告)日：2001-03-20
申请号：US09351222
申请日：1999-07-12
IPC分类号： A61K31415
CPC分类号： A01N43/08 , A61K31/415
摘要： The present invention provides a method to control parasitic mites on beneficial insects, such as honeybees, via the application of a parasiticidally effective amount of tebufenpyrad.
摘要翻译： 本发明提供了一种通过施用杀虫剂有效量的扑热息pyr螨来控制有益昆虫如蜜蜂的寄生螨的方法。
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公开(公告)号：US5583010A
公开(公告)日：1996-12-10
申请号：US73799
申请日：1993-06-10
申请人： William R. Baumbach , John R. Zysk , Michael O. Thorner , Bruce D. Gaylinn , Kevin R. Lynch , Jeffrey K. Harrison
发明人： William R. Baumbach , John R. Zysk , Michael O. Thorner , Bruce D. Gaylinn , Kevin R. Lynch , Jeffrey K. Harrison
CPC分类号： C07K14/723 , C07K14/60 , G01N33/74 , A61K38/00 , G01N2333/60 , G01N2333/726
摘要： Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the receptor. In addition, high affinity biotinylated GHRH analogs have been constructed. Solubilization of GHRH-R/GHRH complexes and extraction of specifically bound GHRH using a mild detergent solution, followed by affinity chromotography, leads to a substantially purified GHRH-R isolate. Electrophoretic treatment of the GHRH-R isolate produces GHRH-R of sufficient purity to conduct sequencing of the receptor. Cloning of a gene encoding for polypeptides (protein or fragments thereof) having GHRH-R activity is accomplished using a bacterial host, and the cloned gene is expressed in a mammalian cell line.
摘要翻译： 生长激素释放激素（GHRH）受体结合已经通过使用碘化GHRH探针的独特结合测定来表征。 已经构建了能够对受体进行光贴标和表征的光亲和性GHRH探针。 此外，已经构建了高亲和力的生物素化GHRH类似物。 GHRH-R / GHRH复合物的溶解和使用温和洗涤剂溶液提取特异性结合的GHRH，然后进行亲和层析，得到基本纯化的GHRH-R分离物。 GHRH-R分离物的电泳处理产生足够纯度的GHRH-R以进行受体的测序。 使用细菌宿主完成编码具有GHRH-R活性的多肽（蛋白质或其片段）的基因的克隆，并且克隆的基因在哺乳动物细胞系中表达。
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