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    Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
    7.
    发明授权
    Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties 失效
    具有抗高血压，心脏保护作用，抗缺血性和抗脂解性的化合物

    公开(公告)号：US06376472B1

    公开(公告)日：2002-04-23

    申请号：US09174191

    申请日：1998-10-16

    申请人： Michael R. Myers ,  Martin P. Maguire ,  Alfred P. Spada ,  William R. Ewing ,  Henry W. Pauls ,  Yong Mi Choi-Sledeski

    发明人： Michael R. Myers ,  Martin P. Maguire ,  Alfred P. Spada ,  William R. Ewing ,  Henry W. Pauls ,  Yong Mi Choi-Sledeski

    IPC分类号： C07D47334

    CPC分类号： C07H19/16 ,  C07D401/04 ,  C07D471/04 ,  C07D473/34

    摘要： A compound of the formula wherein K is N; Q is CH2 or O; R6 is hydrogen, alkyl, allyl, 2-methylallyl, 2-butenyl, or cycloalkyl where the nitrogen of the ring of X is substituted by Y; E is O or S; Y is hydrogen, alkyl, aralkyl, substituted aralkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, or substituted heterocyclylalkyl; and n and p are independently 0, 1, 2, or 3, provided that n+p is at least 1; T is hydrogen, alkyl, alkylcarbonyl, alkylthiocarbonyl, halo, carboxyl, A and B are independently hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or OR′; or a pharmaceutically acceptable salt thereof, a pharmaceutic-ally acceptable prodrug thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof.

    摘要翻译： 化合物K为N; Q是CH 2或O; R6是氢，烷基，烯丙基，2-甲基烯丙基，2-丁烯基或环烷基，X的环的氮被Y取代; E为O或S; Y是氢，烷基，芳烷基，取代的芳烷基，芳基，取代的芳基，杂环基，取代的杂环基，杂环基烷基或取代的杂环基烷基; n和p独立地为0,1,2或3，条件是n + p为至少1; T为氢，烷基，烷基羰基，烷硫基羰基，卤素，羧基，A和B独立地为氢，烷基，羟基烷基， 烷氧基烷基或OR';或其药学上可接受的盐，其药学上可接受的前药，其N-氧化物，其水合物或其溶剂化物。