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公开(公告)号：US5773267A
公开(公告)日：1998-06-30
申请号：US614770
申请日：1996-03-07
CPC分类号： C07K14/005 , C07K14/35 , C12N15/74 , C12N7/00 , C12Q1/6897 , C12N2795/10311 , C12N2795/10322 , C12N2795/10343
摘要： The present invention provides a conditional shuttle phasmid constructed by inserting a cosmid into a non-essential region of the D29 mycobacteriophage which is capable of introducing DNA of interest into the chromosome of mycobacteria, especially M. tuberculosis complex organisms and other slow growing mycobacteria. The present invention provides a recombinant mycobacterium which expresses a DNA of interest incorporated into its chromosome by a conditional shuttle plasmid containing the DNA of interest. The present invention further provides a mycobacterial auxotrophic mutant and method of generating auxotrophic mutants. Finally, the present invention provides a method of inactivating a mycobacterial virulence gene.
摘要翻译： 本发明提供了一种通过将粘粒插入D29分枝杆菌噬菌体的非必需区域而构建的条件穿梭质粒，其能够将感兴趣的DNA引入分枝杆菌染色体，特别是结核分枝杆菌复合生物体和其它缓慢生长的分枝杆菌。 本发明提供了一种重组分枝杆菌，其通过含有感兴趣的DNA的条件穿梭质粒表达目的DNA掺入其染色体中。 本发明还提供了分枝杆菌营养缺陷突变体和产生营养缺陷突变体的方法。 最后，本发明提供灭活分枝杆菌毒力基因的方法。
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公开(公告)号：US5750384A
公开(公告)日：1998-05-12
申请号：US247901
申请日：1994-05-23
CPC分类号： C07K14/005 , C07K14/35 , C12N15/74 , C12N7/00 , C12Q1/6897 , C12N2795/10311 , C12N2795/10322 , C12N2795/10343
摘要： This invention is directed to L5 shuttle phasmids capable of delivering foreign DNA into mycobacteria and to methods of producing L5 shuttle phasmids. In addition, this invention is directed to a method of generating mycobacterial mutations and to a method of producing mycobacterial vaccines.
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公开(公告)号：US5994137A
公开(公告)日：1999-11-30
申请号：US075904
申请日：1998-05-11
CPC分类号： C07K14/005 , C07K14/35 , C12N15/74 , C12N7/00 , C12Q1/6897 , C12N2795/10311 , C12N2795/10322 , C12N2795/10343
摘要： This invention is directed to L5 shuttle phasmids capable of delivering foreign DNA into mycobacteria and to methods of producing L5 shuttle phasmids. In addition, this invention is directed to a method of generating mycobacterial mutations and to a method of producing mycobacterial vaccines.
摘要翻译： 本发明涉及能够将外来DNA转运到分枝杆菌中的L5穿梭质粒以及产生L5穿梭质粒的方法。 此外，本发明涉及产生分枝杆菌突变的方法和生产分枝杆菌疫苗的方法。
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公开(公告)号：US5648392A
公开(公告)日：1997-07-15
申请号：US386917
申请日：1995-02-07
CPC分类号： C30B7/00 , C07C57/18 , C12N9/001 , C30B29/58 , Y10S514/924
摘要： The present invention provides a compound having the structure: ##STR1## wherein R is a branched or unbranched C1-C30 alkyl or alkenyl; or a branched or unbranched C1-C30 alkyl or alkenyl substituted with S, O, N, P, SO.sub.2, F, C1, Br, or I, wherein S, O, N, P, or SO.sub.2 replaces at least one --CH.sub.2 --, and F, Cl, Br, or I replaces at least one H. The present invention also provides a pharmaceutical composition comprising the compound above, as well as a method for treating a mycobacterial disease or infection in a subject in need of such treatment by administering to the subject an effective amount of the compound above.
摘要翻译： 本发明提供具有以下结构的化合物：其中R是支链或非支链C 1 -C 30烷基或链烯基; 或被S，O，N，P，SO 2，F，Cl，Br或I取代的支链或非支链C 1 -C 30烷基或链烯基，其中S，O，N，P或SO 2取代至少一个-CH 2 - ，F，Cl，Br或I取代至少一个H.本发明还提供了包含上述化合物的药物组合物，以及用于治疗需要这种治疗的受试者中的分枝杆菌病或感染的方法 向受试者施用有效量的上述化合物。
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5.发明授权公开(公告)号：US07636861B2
公开(公告)日：2009-12-22
申请号：US11045829
申请日：2005-01-27
CPC分类号： G06F1/3209
摘要： A blade enclosure includes a plurality of blades, an enclosure manager processing device and a bus coupling the enclosure manager processing device to each of the blades. Each blade has at least one power mode bit configured to be controlled by the enclosure manager processing device via the bus, and each blade is configured to cause itself to enter a working state or a sleeping state responsive to its at least one power mode bit.
摘要翻译： 刀片机箱包括多个刀片，机箱管理器处理设备和将机箱管理器处理设备耦合到每个刀片的总线。 每个刀片具有经由总线被配置为由机箱管理器处理设备控制的至少一个功率模式位，并且每个刀片被配置为响应于其至少一个功率模式位而使其自身进入工作状态或休眠状态。
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6.发明申请Firmware modification in a computer system environment supporting operational state changes 有权支持操作状态更改的计算机系统环境中的固件修改公开(公告)号：US20090150662A1
公开(公告)日：2009-06-11
申请号：US11999624
申请日：2007-12-06
IPC分类号： G06F9/44
CPC分类号： G06F8/65
摘要： A method of modifying a computer system firmware includes initiating a firmware modification. At least one prohibited pre-determined operational state is inhibited to prevent the computer system from entering the at least one pre-determined operational state until a subsequent boot. The firmware is modified.
摘要翻译： 修改计算机系统固件的方法包括启动固件修改。 禁止至少一个禁止的预定操作状态以防止计算机系统进入至少一个预定的操作状态，直到后续引导。 固件被修改。
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公开(公告)号：US08984539B2
公开(公告)日：2015-03-17
申请号：US13387301
申请日：2010-02-24
CPC分类号： G06F9/4415
摘要： A device including an interface component configured to couple the device to a computing machine, a storage component configured to store a device driver for the device, and a driver application executed from the storage component and configured to identify the device as a storage device if a device driver has not been loaded onto the computing machine and bad the device driver onto the computing machine in response to the device coupling to the computing machine.
摘要翻译： 一种设备，包括被配置为将所述设备耦合到计算机的接口组件，被配置为存储所述设备的设备驱动程序的存储组件以及从所述存储组件执行的驱动程序应用，并且被配置为将所述设备识别为存储设备，如果 响应于耦合到计算机的设备，设备驱动程序未被加载到计算机上并且将设备驱动程序坏于计算机。
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8.发明授权Firmware modification in a computer system environment supporting operational state changes 有权支持操作状态更改的计算机系统环境中的固件修改公开(公告)号：US08082439B2
公开(公告)日：2011-12-20
申请号：US11999624
申请日：2007-12-06
IPC分类号： G06F9/00 , G06F9/24 , G06F15/177 , G06F9/44
CPC分类号： G06F8/65
摘要： A method of modifying a computer system firmware includes initiating a firmware modification. At least one prohibited pre-determined operational state is inhibited to prevent the computer system from entering the at least one pre-determined operational state until a subsequent boot. The firmware is modified.
摘要翻译： 修改计算机系统固件的方法包括启动固件修改。 禁止至少一个禁止的预定操作状态以防止计算机系统进入至少一个预定的操作状态，直到后续引导。 固件被修改。
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公开(公告)号：US4423379A
公开(公告)日：1983-12-27
申请号：US249359
申请日：1981-03-31
CPC分类号： G01R31/3651 , G01R31/3627 , G01R31/3675
摘要： A system and method for testing a battery having an internal impedance by generating digital battery parameter values corresponding to the battery parameters at different points in time by means of current, voltage and temperature measurement circuits and an analog-to-digital converter. An electrical load is periodically placed on the battery and the battery is also charged between loadings in order to provide battery parameter values during different battery conditions. A microprocessor coordinates the testing of the battery and the measuring of the battery parameter values, as well as the calculation of test criteria based on those values in order to quickly and accurately analyze the condition of the battery.
摘要翻译： 一种用于通过利用电流，电压和温度测量电路以及模拟 - 数字转换器在不同时间点生成对应于电池参数的数字电池参数值来测试具有内部阻抗的电池的系统和方法。 周期性地将电负载放置在电池上，并且电池在负载之间也被充电，以便在不同电池条件期间提供电池参数值。 微处理器协调电池的测试和电池参数值的测量，以及基于这些值的测试标准的计算，以便快速准确地分析电池的状况。
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公开(公告)号：US20120124596A1
公开(公告)日：2012-05-17
申请号：US13387301
申请日：2010-02-24
CPC分类号： G06F9/4415
摘要： A device including an interface component configured to couple the device to a computing machine, a storage component configured to store a device driver for the device, and a driver application executed from the storage component and configured to identify the device as a storage device if a device driver has not been loaded onto the computing machine and bad the device driver onto the computing machine in response to the device coupling to the computing machine.
摘要翻译： 一种设备，包括被配置为将所述设备耦合到计算机的接口组件，被配置为存储所述设备的设备驱动程序的存储组件以及从所述存储组件执行的驱动程序应用，并且被配置为将所述设备识别为存储设备，如果 响应于耦合到计算机的设备，设备驱动程序未被加载到计算机上并且将设备驱动程序坏于计算机。
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