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公开(公告)号：US11446392B2
公开(公告)日：2022-09-20
申请号：US17057415
申请日：2019-05-23
发明人： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
摘要： The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20210205473A1
公开(公告)日：2021-07-08
申请号：US17057415
申请日：2019-05-23
发明人： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
摘要： The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20180182911A1
公开(公告)日：2018-06-28
申请号：US15865662
申请日：2018-01-09
发明人： Zhenqiang Ma , Kanglin Xiong , Hongyi Mi , Tzu-Hsuan Chang , Shaoqin Gong , Jung-Hun Seo
IPC分类号： H01L31/0693
CPC分类号： H01L31/0693 , Y02E10/544 , Y02P70/521
摘要： Tandem solar cells comprising two or more solar cells connected in a solar cell stack via pn diode tunnel junctions and methods for fabricating the tandem solar cells using epitaxial lift off and transfer printing are provided. The tandem solar cells have improved tunnel junction structures comprising a current tunneling layer integrated between the p and n layers of the pn diode tunnel junction that connects the solar cells.
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公开(公告)号：US09437628B1
公开(公告)日：2016-09-06
申请号：US14709850
申请日：2015-05-12
发明人： Zhenqiang Ma , Yei Hwan Jung , Shaoqin Gong , Tzu-Hsuan Chang
IPC分类号： H01L29/00 , H01L21/8234 , H01L21/8244 , H01L27/13 , H01L21/84
CPC分类号： H01L27/13 , H01L21/84 , H01L51/0013 , H01L51/0097
摘要： Substantially biodegradable microwave integrated circuits and method for making the microwave integrated circuits are provided. The integrated circuits, which have applications in high performance flexible microwave and digital electronics, utilize biobased, biodegradable cellulose nanofibril films as a substrate and comprise only very small amounts of potentially toxic inorganic materials.
摘要翻译： 提供了基本可生物降解的微波集成电路和制造微波集成电路的方法。 在高性能柔性微波和数字电子应用中的集成电路利用生物基的可生物降解的纤维素纳米纤维膜作为基底，并且仅包含非常少量的潜在有毒的无机材料。
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公开(公告)号：US20180290891A1
公开(公告)日：2018-10-11
申请号：US15901352
申请日：2018-02-21
发明人： Shaoqin Gong , Qifeng Zheng
IPC分类号： C01B32/198 , C01B32/23 , H01G11/36 , H01G11/38 , H01G11/42 , H01G11/56 , H01M4/131 , H01M4/133
摘要： Electrically conductive aerogel films, electrodes composed of the electrically conductive aerogel films, and supercapacitors incorporating the electrodes are provided. The aerogel films include reduced graphene oxide particles in combination with metal oxynitride fibers. By including cellulosic nanofibrils in the aerogels, the films can be made mechanically flexible and free-standing.
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公开(公告)号：US20230032473A1
公开(公告)日：2023-02-02
申请号：US17741298
申请日：2022-05-10
发明人： Shaoqin Gong , Mingzhou Ye , Yi Zhao
IPC分类号： A61K31/7084 , A61K9/127 , A61K47/02 , A61K47/22 , A61K31/496 , A61K31/192 , A61K31/65 , A61K31/7052 , A61K31/7036 , A61K31/513 , A61K31/522 , A61K31/4174 , A61K31/4196 , A61K31/506 , A61P31/04
摘要： The present technology provides nanoparticles comprising an inorganic core and NAD+ or NADH, coated with a lipid bilayer, wherein the inorganic core is selected from calcium phosphate or a metal organic framework (MOF); the MOF comprises a transition metal ion coordinated to a coordinating ligand, wherein the transition metal ion is selected from the group consisting of zinc, iron, zirconium, copper, and cobalt ions, and the coordinating ligand is selected from an imidazolate ligand or a carboxylate ligand; and the nanoparticle has an average hydrodynamic diameter of from at least 50 nm to less than 1000 nm. Pharmaceutical compositions incorporating such nanoparticles and methods of treating sepsis and/or inflammation with such particles are also provided.
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公开(公告)号：US20220117904A1
公开(公告)日：2022-04-21
申请号：US17506614
申请日：2021-10-20
发明人： Shaoqin Gong , Mingzhou Ye , David R. Andes
IPC分类号： A61K9/51 , A61K9/50 , C08G63/688 , A61P31/04 , A61K31/496
摘要： Provided herein are biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacterial efficacy. Thus, the present technology provides a nanoparticle comprising: a surface comprising one or more polysaccharides having specific binding affinity for bacteria; a core comprising a biodegradable polymer; and an antibacterial drug loaded within the core; wherein the biodegradable polymer comprises nitrogen-containing ionizable functional groups; the one or more polysaccharides having specific binding affinity for bacteria; and disulfide groups; the one or more polysaccharides are attached to the biodegradable polymer through phenyl boronic ester linkages; and the nanoparticle surface displays the polysaccharides such that the polysaccharide are available to bind to a bacterial cell surface.
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公开(公告)号：US11058644B2
公开(公告)日：2021-07-13
申请号：US15819424
申请日：2017-11-21
发明人： Shaoqin Gong , Guojun Chen
IPC分类号： C12N15/11 , A61K9/51 , A61K31/713 , A61P35/00
摘要： Provided are a unimolecular nanoparticle, a composition thereof, and methods of use thereof, and includes 1) a dendritic polymer having a molecular weight of about 500-120,000 Da and terminating in hydroxyl, amino or carboxylic acid groups; 2) cationic polymers attached to at least a majority of the terminating groups of the dendritic polymer via a pH-sensitive linker, wherein each cationic polymer comprises a polymeric backbone attached to cationic functional groups and to weakly basic groups by disulfide bonds, wherein the molar ratio of cationic functional groups to weakly basic groups ranges from 1:1-5:1, and has a molecular weight from about 1,000-5,000 Da; and 3) poly(ethylene glycol) attached to a plurality of cationic polymers and having a terminal group selected from a targeting ligand, OH, O-alkyl, NH2, biotin, or a dye, wherein the terminal group of at least one poly(ethylene glycol) is having a molecular weight of about 1,000-15,000 Da.
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公开(公告)号：US11013695B2
公开(公告)日：2021-05-25
申请号：US16113963
申请日：2018-08-27
发明人： Shaoqin Gong , Amr Abdeen , Krishanu Saha , Guojun Chen , Yuyuan Wang , Ruosen Xie
IPC分类号： A61K9/51 , A61K48/00 , A61K47/32 , C12N15/11 , A61K38/46 , C12N15/113 , A61K31/7105 , A61K9/50 , C12N9/22 , C12N15/90
摘要： Provided herein are nanocapsules comprising a single ribonucleoprotein (RNP) complex as a core and an biodegradable crosslinked polymer shell that encapsulates the core, wherein the RNP complex comprises a Cas9 polypeptide and a guide RNA, and the biodegradable crosslinked polymer shell comprises polymerized monomers of imidazolyl acryloyl monomers, bisacryloyl disulfide monomers (a biodegradable cross-linker), optionally PEG acryloyl monomers, and either cationic acryloyl monomers, anionic acryloyl monomers, or both cationic and anionic acryloyl monomers (optionally in combination with non-ionic acryloyl monomers) as defined herein. Also provided are methods of making the nanocapsules, kits containing the nanocapsules and methods of delivering the encapsulated RNP to cells.
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公开(公告)号：US20200010799A1
公开(公告)日：2020-01-09
申请号：US16506471
申请日：2019-07-09
发明人： Zhenqiang Ma , Juhwan Lee , Yei Hwan Jung , Michael Phillips , David Gamm , Shaoqin Gong , Inkyu Lee
IPC分类号： C12N5/0793
摘要： Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one cube-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one cube-shaped reservoir.
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