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公开(公告)号：US20080274131A1
公开(公告)日：2008-11-06
申请号：US12010107
申请日：2008-01-18
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。
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公开(公告)号：US07320793B2
公开(公告)日：2008-01-22
申请号：US10050898
申请日：2002-01-18
申请人： Wolfgang A Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/385 , A61K9/00 , A61K39/00 , A61K47/30
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。
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公开(公告)号：US20120114674A1
公开(公告)日：2012-05-10
申请号：US13096970
申请日：2011-04-28
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Lüönd , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Lüönd , Matthias Staufenbiel , Peter Frey
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。
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公开(公告)号：US07264810B2
公开(公告)日：2007-09-04
申请号：US10050902
申请日：2002-01-18
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek
IPC分类号： A61K39/385 , A61K9/00 , A61K39/00 , A61K47/30
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。
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公开(公告)号：US20110305723A1
公开(公告)日：2011-12-15
申请号：US12978365
申请日：2010-12-23
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek
IPC分类号： A61K39/385 , C12N9/96 , A61P37/04 , C07K19/00
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。
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公开(公告)号：US20070048287A1
公开(公告)日：2007-03-01
申请号：US11592127
申请日：2006-11-03
申请人： Wolfgang Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek
发明人： Wolfgang Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
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公开(公告)号：US06964769B2
公开(公告)日：2005-11-15
申请号：US09848616
申请日：2001-05-04
申请人： Peter Sebbel , Nicolas Dunant , Martin Bachmann , Alain Tissot , Franziska Lechner , Wolfgang A. Renner , Frank Hennecke , Lars Nieba
发明人： Peter Sebbel , Nicolas Dunant , Martin Bachmann , Alain Tissot , Franziska Lechner , Wolfgang A. Renner , Frank Hennecke , Lars Nieba
IPC分类号： A61K38/00 , A61K39/385 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/245 , C12N15/30 , C12N15/31 , C12N15/33 , C12N15/51 , A61K39/29 , A61K39/295 , C07K14/02 , C07K17/00
CPC分类号： A61K39/385 , A61K38/00 , A61K2039/57 , A61K2039/6068 , A61K2039/625 , C07K14/245 , C07K2319/00 , Y10S530/807
摘要： The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a core particle that is coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions.
摘要翻译： 本发明提供用于产生有序和重复抗原或抗原决定簇的组合物和方法。 本发明的组合物可用于生产用于预防感染性疾病，过敏症的治疗和癌症治疗的疫苗。 作为特定相互作用的结果，本发明的各种实施方案提供以高度有序和重复的方式涂覆任何所需抗原的核心颗粒。
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公开(公告)号：US20060222652A1
公开(公告)日：2006-10-05
申请号：US11270774
申请日：2005-11-10
申请人： Peter Sebbel , Nicolas Dunant , Martin Bachmann , Alain Tissot , Franziska Lechner , Wolfgang Renner , Frank Hennecke , Lars Nieba
发明人： Peter Sebbel , Nicolas Dunant , Martin Bachmann , Alain Tissot , Franziska Lechner , Wolfgang Renner , Frank Hennecke , Lars Nieba
IPC分类号： A61K39/40 , A61K39/295 , A61K39/29 , A61K39/108
CPC分类号： A61K39/385 , A61K38/00 , A61K2039/57 , A61K2039/6068 , A61K2039/625 , C07K14/245 , C07K2319/00 , Y10S530/807
摘要： The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a core particle that is coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions.
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9.发明申请In Vivo Activation of Antigen Presenting Cells for Enhancement of Immune Responses Induced by Virus Like Particles 审中-公开体内激活抗原呈递细胞，增强病毒样颗粒诱导的免疫反应公开(公告)号：US20110293649A1
公开(公告)日：2011-12-01
申请号：US12728008
申请日：2010-03-19
IPC分类号： A61K39/385 , A61P37/04 , A61K39/002 , A61K39/12 , A61K39/02
CPC分类号： A61K39/292 , A61K39/0011 , A61K39/12 , A61K39/385 , A61K39/39 , A61K39/39541 , A61K2039/5258 , A61K2039/55516 , A61K2039/55561 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10141 , C12N2760/10034 , Y02A50/412 , Y02A50/467 , A61K2300/00
摘要： The invention relates to the finding that stimulation of antigen presenting cell (APC) activation using substances such as anti-CD40 antibodies or DNA oligomers rich in non-methylated C and G (CpGs) can dramatically enhance the specific T cell response obtained after vaccination with recombinant virus like particles (VLPs) coupled, fused or otherwise attached to antigens. While vaccination with recombinant VLPs fused to a cytotoxic T cell (CTL) epitope of lymphocytic choriomeningitis virus induced low levels cytolytic activity only and did not induce efficient anti-viral protection, VLPs injected together with anti-CD40 antibodies or CpGs induced strong CTL activity and full anti-viral protection. Thus, stimulation of APC-activation through antigen presenting cell activators such as anti-CD40 antibodies or CpGs can exhibit a potent adjuvant effect for vaccination with VLPs coupled, fused or attached otherwise to antigens.
摘要翻译： 本发明涉及使用诸如抗CD40抗体或含有非甲基化C和G（CpG）的DNA寡聚体的物质刺激抗原呈递细胞（APC）活化的发现可以显着提高接种后获得的特异性T细胞应答 重组病毒样颗粒（VLPs）偶联，融合或以其他方式附着于抗原。 虽然与淋巴细胞性脉络丛脑膜炎病毒的细胞毒性T细胞（CTL）表位融合的重组VLP接种仅诱导低水平的细胞溶解活性，并且不诱导有效的抗病毒保护，但与抗CD40抗体或CpGs一起注射的VLP诱导强的CTL活性， 全面抗病毒保护。 因此，通过抗原呈递细胞活化剂（例如抗CD40抗体或CpG）刺激APC-活化可以显示出与用抗原偶联，融合或连接的VLP进行疫苗接种的有效佐剂效应。
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