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公开(公告)号：US20080274131A1
公开(公告)日：2008-11-06
申请号：US12010107
申请日：2008-01-18
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。
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公开(公告)号：US07320793B2
公开(公告)日：2008-01-22
申请号：US10050898
申请日：2002-01-18
申请人： Wolfgang A Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/385 , A61K9/00 , A61K39/00 , A61K47/30
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。
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公开(公告)号：US20120114674A1
公开(公告)日：2012-05-10
申请号：US13096970
申请日：2011-04-28
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Lüönd , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Lüönd , Matthias Staufenbiel , Peter Frey
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。
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公开(公告)号：US20090246215A1
公开(公告)日：2009-10-01
申请号：US11905986
申请日：2007-10-05
申请人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
CPC分类号： A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇，特别是Abeta1-6肽-VLP组合物的组合物。 更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Abeta1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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公开(公告)号：US07279165B2
公开(公告)日：2007-10-09
申请号：US10622087
申请日：2003-07-18
申请人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Lūönd , Matthias Staufenbiel , Peter Frey
发明人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Lūönd , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/385 , C07K17/06
CPC分类号： A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇，特别是Abeta1-6肽-VLP组合物的组合物。 更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Abeta1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。
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公开(公告)号：US20150374807A1
公开(公告)日：2015-12-31
申请号：US14788896
申请日：2015-07-01
申请人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Martin Lueoend , Matthias Staufenbiel , Peter Frey
发明人： Martin F. Bachmann , Alain Tissot , Rainer Ortmann , Rainer Martin Lueoend , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/00
CPC分类号： A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune, responses within the indicated context.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含有序和重复的抗原或抗原决定簇，特别是Aβ肽-VLP组合物的组合物。 更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Aβ1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别可用于在指定的上下文中有效诱导自身特异性免疫，应答。
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7.发明申请Indolyl-pyrroledione derivatives for the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation 审中-公开用于治疗与β-淀粉样蛋白生成和/或聚集相关的神经和血管障碍的吲哚基 - 吡咯并二酮衍生物公开(公告)号：US20070142401A1
公开(公告)日：2007-06-21
申请号：US10576176
申请日：2004-10-26
申请人： Yves Auberson , Graeme Bilbe , Rainer Kuhn , Peter Von Matt , Heinrich Rueger , Matthias Staufenbiel , Jurgen Wagner , Kaspar Zimmermann
发明人： Yves Auberson , Graeme Bilbe , Rainer Kuhn , Peter Von Matt , Heinrich Rueger , Matthias Staufenbiel , Jurgen Wagner , Kaspar Zimmermann
IPC分类号： A61K31/519 , A61K31/506 , A61K31/4709 , A61K31/404
CPC分类号： A61K31/00 , A61K31/496 , A61K31/517
摘要： The invention relates to the use of an inhibitor of formula (I), or a pharmaceutically acceptable salt thereof having an activity on protein kinases PKC alpha, PKC beta, PKC gamma, PKC epsilon, PKC theta, CDK-1, KDR, PKA, Flt-1, Flt-2, Flt-3 or Flt-4, or on a combination of the above enzymes, for the treatment and/or prevention of neurological and vascular disorders related to beta-amyloid generation and/or aggregation such as neurodegenerative diseases like Down's Syndrome, memory and cognitive impairment, dementia, amyloid neuropathies, brain inflammation, nerve and brain trauma, vascular amyloidosis, or cerebral hemorrhage with amyloidosis.
摘要翻译： 本发明涉及对蛋白激酶PKCα，PKCβ，PKCγ，PKCε，PKCθ，CDK-1，KDR，PKA等具有活性的式（I）抑制剂或其药学上可接受的盐的用途， Flt-1，Flt-2，Flt-3或Flt-4，或上述酶的组合，用于治疗和/或预防与β-淀粉样蛋白产生和/或聚集相关的神经和血管障碍，例如神经变性 疾病如唐氏综合征，记忆和认知障碍，痴呆，淀粉样蛋白神经病，脑炎症，神经和脑外伤，血管淀粉样变性或淀粉样变性脑出血。
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公开(公告)号：US08460676B2
公开(公告)日：2013-06-11
申请号：US12971534
申请日：2010-12-17
IPC分类号： A61K39/295 , A61K38/00 , A61K39/385 , A61K39/12 , A61K35/76 , G01N33/6896 , G01N33/554 , G01N33/569 , C12Q1/68 , C12Q1/70
CPC分类号： A61K39/385 , A61K9/0019 , A61K38/162 , A61K38/22 , A61K39/0007 , A61K45/06 , A61K47/6901 , A61K2039/5258 , A61K2039/6075
摘要： The present invention relates to uses of a construct consisting of virus-like particle (VLP) structure chemically coupled to a fragment of the Aβ-1-42 peptide and its pharmaceutically acceptable salts (hereinafter CONSTRUCT), in particular to dosage regimens, modes of and dosage forms for the administration of a CONSTRUCT for the treatment of patients suffering from dementia, in particular dementia of the Alzheimer's type.
摘要翻译： 本发明涉及由与Aβ1-42肽的片段化学耦合的病毒样颗粒（VLP）结构及其药学上可接受的盐（以下称为CONSTRUCT）构成的构建体的用途，特别是剂量方案 以及用于治疗患有痴呆症，特别是阿尔茨海默氏型痴呆症的患者的结构的剂型。
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9.发明授权Methods of treating dementia by administering virus-like particles coupled to Aβ 有权通过施用与A＆bgr偶联的病毒样颗粒治疗痴呆的方法;公开(公告)号：US07867499B2
公开(公告)日：2011-01-11
申请号：US11718665
申请日：2005-11-03
IPC分类号： A61K39/385 , A61K39/12 , A61K35/76
CPC分类号： A61K39/385 , A61K9/0019 , A61K38/162 , A61K38/22 , A61K39/0007 , A61K45/06 , A61K47/6901 , A61K2039/5258 , A61K2039/6075
摘要： The present invention relates to novel uses of a construct consisting of virus-like particle (VLP) structure chemically coupled to a fragment of the Aβ-1-42 peptide and its pharmaceutically acceptable salts (hereinafter CONSTRUCT), in particular to dosage regimens, modes of and dosage forms for the administration of a CONSTRUCT for the treatment of patients suffering from dementia, in particular dementia of the Alzheimer's type.
摘要翻译： 本发明涉及由与A＆bgr.1-42肽及其药学上可接受的盐（以下称为CONSTRUCT）的片段化学偶联的病毒样颗粒（VLP）结构构成的构建体的新用途，特别是剂量方案， 用于治疗患有痴呆症，特别是阿尔茨海默氏型痴呆症的患者的结构的模式和剂型。
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公开(公告)号：US20090060899A1
公开(公告)日：2009-03-05
申请号：US11718665
申请日：2005-11-03
IPC分类号： A61K39/395 , A61K38/16 , C07K16/18 , C12Q1/02 , A61P25/28 , G01N33/53 , C07H21/00 , C12N15/64
CPC分类号： A61K39/385 , A61K9/0019 , A61K38/162 , A61K38/22 , A61K39/0007 , A61K45/06 , A61K47/6901 , A61K2039/5258 , A61K2039/6075
摘要： The present invention relates to novel uses of a construct consisting of virus-like particle (VLP) structure chemically coupled to a fragment of the Aβ-1-42 peptide and its pharmaceutically acceptable salts (hereinafter CONSTRUCT), in particular to dosage regimens, modes of and dosage forms for the administration of a CONSTRUCT for the treatment of patients suffering from dementia, in particular dementia of the A
摘要翻译： 本发明涉及由与Aβ1-42肽片段化学偶联的病毒样颗粒（VLP）结构及其药学上可接受的盐（以下称为CONSTRUCT）构成的构建体的新用途，特别是剂量方案，模式 用于治疗患有痴呆症的患者的结构的剂型和剂型，特别是A的痴呆
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