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    Amyloid beta1-6 antigen arrays
    4.
    发明申请
    Amyloid beta1-6 antigen arrays 审中-公开
    淀粉样β1-6抗原阵列

    公开(公告)号：US20090246215A1

    公开(公告)日：2009-10-01

    申请号：US11905986

    申请日：2007-10-05

    申请人： Martin F. Bachmann ,  Alain Tissot ,  Rainer Ortmann ,  Rainer Luond ,  Matthias Staufenbiel ,  Peter Frey

    发明人： Martin F. Bachmann ,  Alain Tissot ,  Rainer Ortmann ,  Rainer Luond ,  Matthias Staufenbiel ,  Peter Frey

    IPC分类号： A61K39/00 ,  A61P37/02

    CPC分类号： A61K39/0007 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61K2039/64

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇，特别是Abeta1-6肽-VLP组合物的组合物。 更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Abeta1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

    Amyloid beta1-6 Antigen Arrays
    5.
    发明申请
    Amyloid beta1-6 Antigen Arrays 审中-公开
    淀粉样β1-6抗原阵列

    公开(公告)号：US20150374807A1

    公开(公告)日：2015-12-31

    申请号：US14788896

    申请日：2015-07-01

    申请人： Martin F. Bachmann ,  Alain Tissot ,  Rainer Ortmann ,  Rainer Martin Lueoend ,  Matthias Staufenbiel ,  Peter Frey

    发明人： Martin F. Bachmann ,  Alain Tissot ,  Rainer Ortmann ,  Rainer Martin Lueoend ,  Matthias Staufenbiel ,  Peter Frey

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0007 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61K2039/64

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune, responses within the indicated context.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含有序和重复的抗原或抗原决定簇，特别是Aβ肽-VLP组合物的组合物。 更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Aβ1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别可用于在指定的上下文中有效诱导自身特异性免疫，应答。

    Amyloid β1-6 antigen arrays
    6.
    发明授权
    Amyloid β1-6 antigen arrays 有权
    淀粉样β1-6抗原阵列

    公开(公告)号：US07279165B2

    公开(公告)日：2007-10-09

    申请号：US10622087

    申请日：2003-07-18

    申请人： Martin F. Bachmann ,  Alain Tissot ,  Rainer Ortmann ,  Rainer Lūönd ,  Matthias Staufenbiel ,  Peter Frey

    发明人： Martin F. Bachmann ,  Alain Tissot ,  Rainer Ortmann ,  Rainer Lūönd ,  Matthias Staufenbiel ,  Peter Frey

    IPC分类号： A61K39/385 ,  C07K17/06

    CPC分类号： A61K39/0007 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61K2039/64

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇，特别是Abeta1-6肽-VLP组合物的组合物。 更具体地，本发明提供了包含病毒样颗粒和与其结合的至少一个Abeta1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

    Starting Element With Hydrodynamic Torque Converter
    7.
    发明申请
    Starting Element With Hydrodynamic Torque Converter 有权
    启动元件与流体力学转矩

    公开(公告)号：US20140027230A1

    公开(公告)日：2014-01-30

    申请号：US13950374

    申请日：2013-07-25

    申请人： Georg Mencher ,  Peter Frey ,  Jörg Sudau

    发明人： Georg Mencher ,  Peter Frey ,  Jörg Sudau

    IPC分类号： F16H41/04

    CPC分类号： F16H45/02 ,  F16H2041/246 ,  F16H2045/0226 ,  F16H2045/0263 ,  F16H2045/0284

    摘要： A starting element for transmitting torque from a drive-side rotational input (14) of the starting element to a driven hub (8) includes a hydrodynamic torque converter (4) which has a turbine coupled to the driven hub (8) so as to be fixed with respect to rotation relative to it and which comprises a turbine shell (56) with turbine blades (22) arranged therein. A maximum extension of the turbine shell (56) opposite an axial direction (12) terminates at a first axial position (53), and an impeller (20) located opposite the turbine in the axial direction (12). A stator (24) is arranged between the turbine and the impeller (22) and is coupled via a stator flange (58) to a freewheel (52) adjoining the driven hub (8) in an axial direction (12). A center of the freewheel (52) is located at a second axial position (54). A difference between the first axial position (53) and the second axial position (54) is greater than a predetermined minimum value.

    摘要翻译： 用于将扭矩从起动元件的驱动侧旋转输入（14）传递到从动轮毂（8）的启动元件包括具有联接到从动轮毂（8）的涡轮的流体动力学变矩器（4），以便 相对于其旋转而被固定，并且其包括具有布置在其中的涡轮叶片（22）的涡轮壳体（56）。 涡轮壳体（56）的与轴向方向（12）相反的最大延伸部终止于第一轴向位置（53）和在轴向（12）处与涡轮机相对定位的叶轮（20）。 定子（24）布置在涡轮机和叶轮（22）之间，并且经由定子凸缘（58）被耦合到沿着轴向方向（12）邻接从动轮毂（8）的自由轮（52）。 自由轮（52）的中心位于第二轴向位置（54）。 第一轴向位置（53）和第二轴向位置（54）之间的差异大于预定的最小值。

    Torque Transmission Device With Electrical Insulation
    8.
    发明申请
    Torque Transmission Device With Electrical Insulation 审中-公开
    带绝缘的扭矩传动装置

    公开(公告)号：US20130125538A1

    公开(公告)日：2013-05-23

    申请号：US13670695

    申请日：2012-11-07

    申请人： Peter Frey ,  Michael Heuler ,  Georg Mencher

    发明人： Peter Frey ,  Michael Heuler ,  Georg Mencher

    IPC分类号： F16C33/02 ,  F16C33/30

    CPC分类号： F16C33/02 ,  F02N11/08 ,  F16C17/04 ,  F16C17/24 ,  F16C19/30 ,  F16C19/52 ,  F16C33/30 ,  F16C2202/30 ,  F16H41/24 ,  F16H57/021

    摘要： A torque transmission device, particularly for a motor vehicle, for the transmission of a torque from a driving unit, particularly from an internal combustion engine, to a driven unit, particularly a transmission, has at least one bearing location which has at least one bearing support acting in axial and/or radial direction, wherein an insulation element preventing a flow of electric current is provided in the region of the at least one bearing location.

    摘要翻译： 特别是用于机动车辆的扭矩传递装置用于将来自驱动单元，特别是内燃机的转矩传递到从动单元，特别是变速器的转矩传递装置具有至少一个轴承位置，其具有至少一个轴承 支撑件在轴向和/或径向方向上作用，其中在所述至少一个轴承位置的区域中提供防止电流流动的绝缘元件。

    ILLUMINATION UNIT FOR VEHICLE HEADLIGHTS AND VEHICLE HEADLIGHTS
    9.
    发明申请
    ILLUMINATION UNIT FOR VEHICLE HEADLIGHTS AND VEHICLE HEADLIGHTS 有权
    车灯和车尾灯照明单元

    公开(公告)号：US20120020104A1

    公开(公告)日：2012-01-26

    申请号：US13259188

    申请日：2010-03-29

    申请人： Alois Biebl ,  Peter Frey ,  Ralf Vollmer

    发明人： Alois Biebl ,  Peter Frey ,  Ralf Vollmer

    IPC分类号： F21V15/01

    CPC分类号： F21V25/00 ,  F21K9/00 ,  F21S41/192 ,  F21S45/48 ,  F21Y2115/10

    摘要： An illumination unit for vehicle headlights may include a light-emitting diode device, a housing and an assembly board on which components of an operating circuit for operating the light-emitting diode device are arranged, wherein the housing and the assembly board define an interior space, wherein the assembly board has at least one electrically conductive inner layer that is connected to a ground reference potential of the operating circuit and on its surface the assembly board has at least one electrical contact surface which is contacted with at least one electrically conductive inner layer, and the housing has an electromagnetic shielding structure configured to provide electromagnetic shielding of the interior space, wherein the electromagnetic shielding structure is connected to the at least one electrical contact surface.

    摘要翻译： 用于车辆前灯的照明单元可以包括发光二极管装置，壳体和组装板，其上布置有用于操作发光二极管装置的操作电路的部件，其中壳体和组装板限定内部空间 ，其中所述组装板具有至少一个导电内层，其连接到所述操作电路的接地参考电位，并且在其表面上，所述组装板具有至少一个电接触表面，所述至少一个电接触表面与至少一个导电内层 并且所述壳体具有电磁屏蔽结构，其构造成提供所述内部空间的电磁屏蔽，其中所述电磁屏蔽结构连接到所述至少一个电接触表面。

    LED HEADLIGHT
    10.
    发明申请
    LED HEADLIGHT 审中-公开
    LED头灯

    公开(公告)号：US20100277941A1

    公开(公告)日：2010-11-04

    申请号：US12743575

    申请日：2008-11-17

    申请人： Peter Frey ,  Christian Meier

    发明人： Peter Frey ,  Christian Meier

    IPC分类号： B60Q1/04

    CPC分类号： F21V29/71 ,  F21S41/141 ,  F21S45/33 ,  F21S45/43 ,  F21S45/46 ,  F21S45/47 ,  F21S45/48 ,  F21V29/56 ,  F21V29/89 ,  F21Y2115/10

    摘要： An LED headlight may include at least one heat-conducting element that extends from at least one heat source located in a headlight housing to at least one cooling element in such a way as to make thermal contact and which is arranged at least partially outside on the headlight housing, the heat-conducting element being movable.

    摘要翻译： LED头灯可以包括至少一个导热元件，其从位于头灯壳体中的至少一个热源延伸到至少一个冷却元件，以便进行热接触并且至少部分地布置在 头灯壳体，导热元件可移动。