Amyloid beta1-6 antigen arrays
    1.
    发明申请
    Amyloid beta1-6 antigen arrays 审中-公开
    淀粉样β1-6抗原阵列

    公开(公告)号:US20090246215A1

    公开(公告)日:2009-10-01

    申请号:US11905986

    申请日:2007-10-05

    IPC分类号: A61K39/00 A61P37/02

    摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇,特别是Abeta1-6肽-VLP组合物的组合物。 更具体地,本发明提供了包含病毒样颗粒和与其结合的至少一个Abeta1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物,并有效诱导免疫应答,特别是抗体应答。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

    Amyloid β1-6 antigen arrays
    4.
    发明授权
    Amyloid β1-6 antigen arrays 有权
    淀粉样β1-6抗原阵列

    公开(公告)号:US07279165B2

    公开(公告)日:2007-10-09

    申请号:US10622087

    申请日:2003-07-18

    IPC分类号: A61K39/385 C07K17/06

    摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇,特别是Abeta1-6肽-VLP组合物的组合物。 更具体地,本发明提供了包含病毒样颗粒和与其结合的至少一个Abeta1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物,并有效诱导免疫应答,特别是抗体应答。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

    Amyloid beta1-6 Antigen Arrays
    5.
    发明申请
    Amyloid beta1-6 Antigen Arrays 审中-公开
    淀粉样β1-6抗原阵列

    公开(公告)号:US20150374807A1

    公开(公告)日:2015-12-31

    申请号:US14788896

    申请日:2015-07-01

    IPC分类号: A61K39/00

    摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune, responses within the indicated context.

    摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供了包含有序和重复的抗原或抗原决定簇,特别是Aβ肽-VLP组合物的组合物。 更具体地,本发明提供了包含病毒样颗粒和与其结合的至少一个Aβ1-6肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗阿尔茨海默氏病的疫苗和作为预防或治愈阿尔茨海默氏病的药物,并有效诱导免疫应答,特别是抗体应答。 此外,本发明的组合物特别可用于在指定的上下文中有效诱导自身特异性免疫,应答。

    Il-15 Antigen Arrays And Uses Thereof
    7.
    发明申请
    Il-15 Antigen Arrays And Uses Thereof 审中-公开
    Il-15抗原阵列及其用途

    公开(公告)号:US20090123414A1

    公开(公告)日:2009-05-14

    申请号:US11792749

    申请日:2005-12-12

    IPC分类号: A61K48/00 A61K39/20

    摘要: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-15 protein, an IL-15 mutein or an IL-15 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-15 protein, IL-15 mutein or at least one IL-15 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory and chronic autoimmune diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译: 本发明涉及分子生物学,病毒学,免疫学和医学领域。 本发明提供了包含有序重复抗原阵列的组合物,其中所述抗原是IL-15蛋白,IL-15突变蛋白或IL-15片段。 更具体地,本发明提供包含病毒样颗粒和至少一种IL-15蛋白,IL-15突变蛋白或与其连接的至少一个IL-15片段的组合物。 本发明还提供了一种制备该组合物的方法。 本发明的组合物可用于生产用于治疗炎性和慢性自身免疫性疾病的疫苗。 本发明的组合物有效诱导免疫应答,特别是抗体应答。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

    T-Cadherin antigen arrays and uses thereof
    9.
    发明申请
    T-Cadherin antigen arrays and uses thereof 审中-公开
    T-Cadherin抗原阵列及其用途

    公开(公告)号:US20090123471A1

    公开(公告)日:2009-05-14

    申请号:US11666497

    申请日:2005-10-31

    摘要: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a T-cadherin domain protein, a combination of any T-cadherin domain proteins, a T-cadherin domain fragment or a combination of any T-cadherin domain fragments, linked to the VLP respectively. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of T-cadherin related disease, and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译: 本发明涉及医药,公共卫生,免疫学,分子生物学和病毒学领域。 本发明尤其提供了包含病毒样颗粒(VLP)和至少一种抗原的组合物,其中所述抗原是T-cadherin结构域蛋白,任何T-cadherin结构域蛋白,T-钙粘蛋白 结构域片段或与VLP分别连接的任何T-cadherin结构域片段的组合。 本发明还提供了一种制备上述组合物的方法。 本发明的组合物可用于疫苗的制备,特别是用于预防和/或治疗T-钙粘蛋白相关疾病,特别是通过诱导有效的免疫应答,特别是抗体应答。 此外,本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。