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公开(公告)号：US20070265324A1
公开(公告)日：2007-11-15
申请号：US11623996
申请日：2007-01-17
申请人： Wolfgang Wernet , Thomas Penning , Vincent Giranda
发明人： Wolfgang Wernet , Thomas Penning , Vincent Giranda
IPC分类号： A61K31/4184 , A61P35/02 , C07D235/04
CPC分类号： C07D403/04 , A61K31/41 , A61K31/4164 , A61K41/0038 , A61K45/06 , A61N2005/1098 , A61K2300/00
摘要： The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
摘要翻译： 本发明描述了式（I）的苯并咪唑衍生物，其与放射治疗组合或与其它化学治疗剂组合地构成有效的PARP抑制剂。
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公开(公告)号：US20070249597A1
公开(公告)日：2007-10-25
申请号：US11675570
申请日：2007-02-15
IPC分类号： A61K31/47 , A61K31/497 , A61K31/53 , A61K31/535 , A61P29/00
CPC分类号： C07D471/04 , A61K31/47 , A61K31/497 , A61K31/53 , A61K31/535 , C07D491/04 , C07D495/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US20080015192A1
公开(公告)日：2008-01-17
申请号：US11753279
申请日：2007-05-24
申请人： Robert Diebold , Stevan Djuric , Vincent Giranda , Laura Hexamer , Nan-Horng Lin , Julie Miyashiro , Thomas Penning , Magdalena Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith Woods , Zhiren Xia , Henry Zhang
发明人： Robert Diebold , Stevan Djuric , Vincent Giranda , Laura Hexamer , Nan-Horng Lin , Julie Miyashiro , Thomas Penning , Magdalena Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith Woods , Zhiren Xia , Henry Zhang
IPC分类号： A61K31/50 , A61K31/34 , A61K31/40 , A61K31/505 , A61P35/00 , C07D233/61 , C07D239/24 , C07D307/04 , C07D413/02 , C07D277/08 , C07D239/20 , C07D207/30 , A61K31/5377 , A61K31/4164 , A61K31/425
CPC分类号： C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要： Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
摘要翻译： 公开了抑制Plk1的化合物，含有该化合物的组合物和使用该化合物治疗疾病的方法。
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4.发明申请公开(公告)号：US20060229351A1
公开(公告)日：2006-10-12
申请号：US11401635
申请日：2006-04-11
申请人： Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Thomas Penning , Vincent Giranda , Sheela Thomas
发明人： Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Thomas Penning , Vincent Giranda , Sheela Thomas
IPC分类号： A61K31/4184
CPC分类号： C07D235/14 , C07D401/04 , C07D401/12 , C07D403/06
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包括式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US20080015182A1
公开(公告)日：2008-01-17
申请号：US11765776
申请日：2007-06-20
申请人： Thomas Penning , Sheela Thomas , Philip Hajduk , Daryl Sauer , Kathy Sarris , Vincent Giranda
发明人： Thomas Penning , Sheela Thomas , Philip Hajduk , Daryl Sauer , Kathy Sarris , Vincent Giranda
IPC分类号： A61K31/517 , A61K31/496 , A61K31/5377 , A61K31/55 , A61P29/00 , A61P31/00 , A61P35/00 , C07D233/02 , C07D239/72 , C07D295/00
CPC分类号： C07D487/04
摘要： The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
摘要翻译： 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。
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6.发明申请1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS 有权在2位置上被苯基取代的苯并咪唑-4-羧酰胺是一种残留的PARP抑制剂公开(公告)号：US20070179136A1
公开(公告)日：2007-08-02
申请号：US11536994
申请日：2006-09-29
申请人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Vincent Giranda
发明人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Virajkumar Gandhi , Jianchun Gong , Vincent Giranda
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4184 , C07D413/14 , C07D403/02
CPC分类号： C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10
摘要： Compound having formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
摘要翻译： 具有式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含具有式（I）的化合物，包括具有式（I）的化合物的处理方法的药物组合物，以及包含具有式（I）的化合物的PARP酶的抑制方法。
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公开(公告)号：US20060229289A1
公开(公告)日：2006-10-12
申请号：US11401638
申请日：2006-04-11
IPC分类号： A61K31/55 , A61K31/454 , A61K31/4184 , C07D403/04
CPC分类号： C07D403/04 , C07D207/16 , C07D401/04 , C07D401/14 , C07D405/14
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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公开(公告)号：US20080108659A1
公开(公告)日：2008-05-08
申请号：US11867369
申请日：2007-10-04
IPC分类号： A61K31/454 , C07D401/00 , A61K31/4035 , A61P37/08 , A61P35/00 , A61P39/02 , A61K31/4025 , C07D209/44
CPC分类号： C07D209/44 , C07D209/46 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/06
摘要： Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.
摘要翻译： 公开了抑制聚（ADP-核糖）聚合酶活性的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。
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9.发明申请SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-羧酰胺是残留的PARP抑制剂公开(公告)号：US20070270476A1
公开(公告)日：2007-11-22
申请号：US11830318
申请日：2007-07-30
申请人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
发明人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
IPC分类号： A61K31/4164 , A61K31/426 , A61P29/00 , A61P31/04 , A61P35/00 , C07D235/04 , C07D277/20
CPC分类号： C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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公开(公告)号：US20070112047A1
公开(公告)日：2007-05-17
申请号：US11560166
申请日：2006-11-15
申请人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
发明人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
IPC分类号： A61K31/427 , A61K31/4184 , C07D413/04 , C07D235/04
CPC分类号： C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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