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1.发明申请ANTI-HBC QUANTITATIVE DETECTION METHOD AND USES THEREOF IN MONITORING AND CONTROLLING DISEASE PROGRESSION OF CHRONIC HEPATITIS B PATIENT AND IN PREDICTING THERAPEUTIC EFFECT 有权抗HBC定量检测方法及其在监测和控制慢性乙型肝炎患者疾病进展和预防治疗效果方面的应用公开(公告)号：US20150118674A1
公开(公告)日：2015-04-30
申请号：US14373611
申请日：2013-01-17
发明人： Quan Yuan , Liuwei Song , Wenbin Zhou , Zuxing Weng , Feihai Xu , Shengxiang Ge , Jun Zhang , Ningshao Xia
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N33/5762 , G01N2333/02 , G01N2469/20 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to a method for quantitative detection of anti-HBc and its use in monitoring disease progression of chronic hepatitis B patients and predicting therapeutic effects. By quantitative detection of antibodies against hepatitis B core protein (Anti-HBc), it is able to monitor disease progression of chronic hepatitis B patients, effectively predict therapeutic effects in chronic hepatitis B patients who accept a therapy against hepatitis B virus (especially, a therapy based on interferon and a therapy based on nucleoside/nucleotide analogue anti-HBV drug), and thus guide the patients to reasonably choose drugs.
摘要翻译： 本发明涉及一种用于定量检测抗HBc的方法及其在监测慢性乙型肝炎患者疾病进展和预测治疗效果中的应用。 通过定量检测抗乙型肝炎核心蛋白（Anti-HBc）的抗体，能够监测慢性乙型肝炎患者的疾病进展，有效预测接受乙型肝炎病毒治疗的慢性乙型肝炎患者的治疗效果（特别是 基于干扰素的治疗和基于核苷/核苷酸类似物抗HBV药物的治疗），从而指导患者合理选择药物。
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公开(公告)号：US09952217B2
公开(公告)日：2018-04-24
申请号：US14373611
申请日：2013-01-17
发明人： Quan Yuan , Liuwei Song , Wenbin Zhou , Zuxing Weng , Feihai Xu , Shengxiang Ge , Jun Zhang , Ningshao Xia
IPC分类号： G01N33/576 , G01N33/569
CPC分类号： G01N33/56983 , G01N33/5762 , G01N2333/02 , G01N2469/20 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to a method for quantitative detection of anti-HBc and its use in monitoring disease progression of chronic hepatitis B patients and predicting therapeutic effects. By quantitative detection of antibodies against hepatitis B core protein (Anti-HBc), it is able to monitor disease progression of chronic hepatitis B patients, effectively predict therapeutic effects in chronic hepatitis B patients who accept a therapy against hepatitis B virus (especially, a therapy based on interferon and a therapy based on nucleoside/nucleotide analog anti-HBV drug), and thus guide the patients to reasonably choose drugs.
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3.发明申请Method for In-Vitro Preparation of Double-Layered Virus-Like Particles of Rotavirus 有权轮状病毒双层病毒样颗粒体外制备方法公开(公告)号：US20150252334A1
公开(公告)日：2015-09-10
申请号：US14429586
申请日：2013-06-24
发明人： Shengxiang Ge , Tingdong Li , Qingshun Guo , Feihai Xu , Jun Zhang , Ningshao Xia
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K38/162 , A61K39/00 , C12N7/04 , C12N2720/12322 , C12N2720/12323 , C12N2720/12333 , C12N2720/12334 , C12N2720/12352
摘要： The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.
摘要翻译： 本发明涉及一种体外制备轮状病毒双层病毒样颗粒的方法。 该方法包括以下步骤：从裂解上清液中纯化轮状病毒VP6蛋白，以及体外组装由VP2蛋白和VP6蛋白组成的双层病毒样颗粒，其中蛋白质和病毒样颗粒可用于预防或 减少轮状病毒感染引起的临床症状。
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公开(公告)号：US09862933B2
公开(公告)日：2018-01-09
申请号：US14429586
申请日：2013-06-24
发明人： Shengxiang Ge , Tingdong Li , Qingshun Guo , Feihai Xu , Jun Zhang , Ningshao Xia
CPC分类号： C12N7/00 , A61K38/162 , A61K39/00 , C12N7/04 , C12N2720/12322 , C12N2720/12323 , C12N2720/12333 , C12N2720/12334 , C12N2720/12352
摘要： The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.
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公开(公告)号：US11543413B2
公开(公告)日：2023-01-03
申请号：US16768848
申请日：2018-11-30
发明人： Shunhua Wen , Liuwei Song , Zuxing Weng , Haijun Lin , Feihai Xu , Xudong Sun , Shengxiang Ge
IPC分类号： G01N33/576 , G01N33/543
摘要： A kit for quantitatively detecting HBsAg and a method for quantitatively detecting an HBsAg content in a sample containing HBsAg. The kit comprises a first antibody specifically binding to HBsAg and a reagent composition. The reagent composition comprises tris(2-carboxyethyl)phosphine hydrochloride (TCEP) and urea.
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