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公开(公告)号：US07473703B2
公开(公告)日：2009-01-06
申请号：US11501594
申请日：2006-08-08
申请人： Xian Yun Jiao , Frank Kayser , David J. Kopecky , Sharon McKendry , Derek E. Piper , Andrew K. Shiau
发明人： Xian Yun Jiao , Frank Kayser , David J. Kopecky , Sharon McKendry , Derek E. Piper , Andrew K. Shiau
IPC分类号： A61K31/40 , C07D207/325
CPC分类号： C07D207/333 , C07D207/335
摘要： Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases.
摘要翻译： 提供了可用于治疗脂质疾病，代谢紊乱和细胞增殖性疾病的杂环芳基磺酰氨基苄基化合物。
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公开(公告)号：US07112606B2
公开(公告)日：2006-09-26
申请号：US10354923
申请日：2003-01-29
申请人： Xian Yun Jiao , Frank Kayser , David J. Kopecky , Sharon McKendry , Derek E. Piper , Andrew K. Shiau
发明人： Xian Yun Jiao , Frank Kayser , David J. Kopecky , Sharon McKendry , Derek E. Piper , Andrew K. Shiau
IPC分类号： A61K31/40 , C07D207/30
CPC分类号： C07D207/333 , C07D207/335
摘要： Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases.
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公开(公告)号：US07326812B2
公开(公告)日：2008-02-05
申请号：US11333958
申请日：2006-01-17
IPC分类号： C07C311/15
CPC分类号： C07D207/33 , C07C311/21 , C07C317/32 , C07C2601/08 , C07C2601/16 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/42 , C07D231/12 , C07D233/61 , C07D233/64 , C07D235/12 , C07D235/14 , C07D239/26 , C07D257/04 , C07D277/24 , C07D277/28 , C07D333/34 , C07F7/081
摘要： Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases.
摘要翻译： 提供了芳基磺酰胺苄醇，胺和磺酰胺，其可用于治疗脂质疾病，代谢疾病和细胞增殖性疾病。
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公开(公告)号：US07071358B2
公开(公告)日：2006-07-04
申请号：US10354922
申请日：2003-01-29
IPC分类号： C07C311/37 , A61K31/18
CPC分类号： C07D207/33 , C07C311/21 , C07C317/32 , C07C2601/08 , C07C2601/16 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/42 , C07D231/12 , C07D233/61 , C07D233/64 , C07D235/12 , C07D235/14 , C07D239/26 , C07D257/04 , C07D277/24 , C07D277/28 , C07D333/34 , C07F7/081
摘要： Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases.
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![Substituted pyrazolo[3,4-d]pyrimidines as ACK-1 and LCK inhibitors](/abs-image/US/2010/07/27/US07763624B2/abs.jpg.150x150.jpg)
5.发明授权公开(公告)号：US07763624B2
公开(公告)日：2010-07-27
申请号：US11506381
申请日：2006-08-18
申请人： John L. Buchanan , William H. Buckner , Mario G. Cardozo , Erin F. DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Yun Jiao , Frank Kayser , David J. Kopecky , Craig E. Masse , Susan A. Tomlinson , Ryan White , Xiaotian Zhu
发明人： John L. Buchanan , William H. Buckner , Mario G. Cardozo , Erin F. DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Yun Jiao , Frank Kayser , David J. Kopecky , Craig E. Masse , Susan A. Tomlinson , Ryan White , Xiaotian Zhu
IPC分类号： C07D487/04 , A61K31/519 , A61K31/496 , A61P35/00 , C07D231/56 , A61K31/416
CPC分类号： C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要： The present invention relates to compounds of Formula I or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译： 本发明涉及式I化合物或立体异构体，互变异构体，溶剂合物，药学上可接受的盐或前药，含有化合物的药物制剂，使用该化合物的治疗方法，例如蛋白质酪氨酸激酶相关 诸如免疫学和肿瘤学障碍的疾病以及制备包含该化合物的药物的方法。
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公开(公告)号：US07635695B2
公开(公告)日：2009-12-22
申请号：US11709895
申请日：2007-02-21
申请人： Simon A. Burkitt , Mario G. Cardozo , Timothy D. Cushing , Michael R. DeGraffenreid , Christopher N. Farthing , Xiaolin Hao , Juan C. Jaen , Xian Yun Jiao , David J. Kopecky , Marc Labelle , Sarah E. Lively , Dustin L. McMinn , Sven P. Rasmussen , Youngsook Shin , Marie-Louise Smith , Andrew Smith
发明人： Simon A. Burkitt , Mario G. Cardozo , Timothy D. Cushing , Michael R. DeGraffenreid , Christopher N. Farthing , Xiaolin Hao , Juan C. Jaen , Xian Yun Jiao , David J. Kopecky , Marc Labelle , Sarah E. Lively , Dustin L. McMinn , Sven P. Rasmussen , Youngsook Shin , Marie-Louise Smith , Andrew Smith
IPC分类号： A61K31/5377 , A61K31/4365 , C07D413/14 , C07D495/04
CPC分类号： C07D231/56 , C07D239/74 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.
摘要翻译： 本文提供了可用于治疗炎症，免疫调节，代谢，感染和细胞增殖性疾病或病症的化合物，组合物和方法。 特别地，本发明提供调节参与炎症，代谢，感染和细胞增殖的蛋白质的表达和/或功能的化合物。 主题化合物含有稠合的杂双环。
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公开(公告)号：US07572934B2
公开(公告)日：2009-08-11
申请号：US12082645
申请日：2008-04-10
申请人： Sean P. Brown , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd J. Kohn , Vatee Pattaropong , Marc Vimolratana , Michael J. Schmitt
发明人： Sean P. Brown , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd J. Kohn , Vatee Pattaropong , Marc Vimolratana , Michael J. Schmitt
IPC分类号： C07C63/33 , C07C335/00 , A01N43/40 , A01N37/10
CPC分类号： C07C59/68 , C07C59/72 , C07D261/08
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US08030354B2
公开(公告)日：2011-10-04
申请号：US12287036
申请日：2008-10-03
申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
IPC分类号： A61K31/192 , C07C53/134
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20080090840A1
公开(公告)日：2008-04-17
申请号：US11900006
申请日：2007-09-06
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Michael Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Michael Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/41 , A61K31/42 , A61K31/44 , A61K31/4965 , A61P43/00 , C07D241/36 , C07D261/06 , C07D271/06 , C07D277/30 , C07D413/00
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20090137561A1
公开(公告)日：2009-05-28
申请号：US12287036
申请日：2008-10-03
申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Xiang Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Xiang Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
IPC分类号： C07C59/48 , A61K31/192 , A61K31/235 , C07C69/76 , C07D309/00 , A61K31/351 , C07D211/20 , A61K31/445 , A61K31/44 , A61K31/55 , C07D223/04 , A61P7/00
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
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