HYPERSULFATED DISACCHARIDES TO TREAT ELASTASE RELATED DISORDERS
    9.
    发明申请
    HYPERSULFATED DISACCHARIDES TO TREAT ELASTASE RELATED DISORDERS 审中-公开
    用于治疗ELASTASE相关疾病的超大异味

    公开(公告)号:US20130203695A1

    公开(公告)日:2013-08-08

    申请号:US13880875

    申请日:2011-10-27

    摘要: Hypersulfated disaccharides of formula I and other hypersulfated disaccharides disclosed herein are used to treat diseases or conditions associated with human neutrophil elastase imbalances. The disaccharides and/or intermediates useful to prepare such compounds are prepared from heparin. The diseases and conditions which are treated with a compound of formula I include chronic obstructive pulmonary disorder (COPD) and cystic fibrosis (CF). The formulations are delivered to the lungs in an aerosol formulation or dry powder means or via nebulization. Oral forms are also suitable.

    摘要翻译: 式I的过硫酸二糖和本文公开的其它超硫酸化二糖用于治疗与人嗜中性粒细胞弹性蛋白酶失衡相关的疾病或病症。 用于制备这些化合物的二糖和/或中间体由肝素制备。 用式I化合物治疗的疾病和病症包括慢性阻塞性肺病(COPD)和囊性纤维化(CF)。 制剂以气溶胶制剂或干粉手段或通过雾化递送至肺。 口服形式也适用。