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    Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses
    3.
    发明申请
    Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses 审中-公开
    淀粉样蛋白β肽类似物，其低聚物，包含所述类似物或寡聚物的制备和组合的方法及其用途

    公开(公告)号：US20110092445A1

    公开(公告)日：2011-04-21

    申请号：US12509325

    申请日：2009-07-24

    申请人： Stefan Barghorn ,  Heinz Hillen ,  Rohinton Edalji ,  Leo Barrett ,  Paul Richardson ,  Liping Yu ,  Edward Olejniczak ,  John E. Harlan ,  Thomas Holzman

    发明人： Stefan Barghorn ,  Heinz Hillen ,  Rohinton Edalji ,  Leo Barrett ,  Paul Richardson ,  Liping Yu ,  Edward Olejniczak ,  John E. Harlan ,  Thomas Holzman

    IPC分类号： A61K38/12 ,  C07K4/00 ,  C07K14/00 ,  G01N33/68

    CPC分类号： C07K14/4711 ,  A61K38/00 ,  C07K16/18 ,  C07K2319/00 ,  G01N2333/4709 ,  G01N2500/04 ,  G01N2800/2821

    摘要： The present invention relates to an amyloid β peptide analogues comprising an amino acid sequence or a peptidomimetic thereof, wherein the sequence (i) forms a loop, (ii) has at least 66% identity to the amino acid sequence of native Aβ peptide or a portion thereof, (iii) comprises at least 6 contiguous amino acid residues and (iv) has at least 2 non-contiguous amino acid residues which are covalently linked with each other, oligomers comprising a plurality of said amyloid β peptide analogues, processes for preparing the amyloid β peptide analogues or oligomers, compositions comprising the amyloid β peptide analogues or oligomers, and uses of the amyloid β peptide analogues or oligomers such as their use for treating or preventing an amyloidosis (e.g. by active immunization), for diagnosing an amyloidosis, and for providing agents that are capable of binding to the amyloid β peptide analogues or oligomers. The subject invention also describes agents that are capable of binding to the amyloid β peptide analogues or oligomers, e.g. antibodies, compositions comprising the agents, and uses of the agents such as their use for treating or preventing an amyloidosis (e.g. by passive immunization) and for diagnosing an amyloidosis.

    摘要翻译： 本发明涉及淀粉样蛋白 肽类似物，其包含氨基酸序列或其拟肽，其中所述序列（i）形成环，（ii）与天然A和Bgr的氨基酸序列具有至少66％的同一性; 肽或其一部分，（iii）包含至少6个连续氨基酸残基和（iv）具有彼此共价连接的至少2个不连续氨基酸残基，包含多个所述淀粉样蛋白和bgr的寡聚物; 肽类似物，制备淀粉样蛋白的方法 肽类似物或寡聚物，包含淀粉样蛋白的组合物; 肽类似物或寡聚物，以及淀粉样蛋白和bgr的用途; 肽类似物或寡聚体，例如其用于治疗或预防淀粉样变性（例如通过主动免疫）用于诊断淀粉样变性的用途，以及用于提供能够结合淀粉样蛋白的药剂; 肽类似物或寡聚物。 本发明还描述了能够结合淀粉样蛋白的药剂; 肽类似物或寡聚物，例如 抗体，包含该试剂的组合物，以及该药剂的用途，例如其用于治疗或预防淀粉样变性（例如通过被动免疫）和用于诊断淀粉样变性的用途。

    Mine shaft liner
    6.
    发明授权
    Mine shaft liner 失效
    矿井轴衬

    公开(公告)号：US4460293A

    公开(公告)日：1984-07-17

    申请号：US165384

    申请日：1980-07-03

    申请人： Paul Richardson ,  David A. Whitley

    发明人： Paul Richardson ,  David A. Whitley

    IPC分类号： B66C1/66 ,  E21B19/06 ,  E21B23/00 ,  E21D5/12 ,  E21D5/01

    CPC分类号： E21B23/00 ,  B66C1/66 ,  E21B19/06 ,  E21D5/12

    摘要： In the mining of minerals from the earth, it is necessary to drill deep bore holes typically between 3000 and 6000 feet in the earth. In order to protect those entering the hole for additional mining operations, after drilling the hole, the hole is lined with a stack of specially constructed lining segments. These segments are formed of either prestressed concrete or steel. The segments are lowered one at a time into the bore hole so as to build up a stack within the hole, thereby lining the hole. The segments are carried to the hole on a transporter and then lowered by the transporter into the hole. Guide cables are threaded through guide conduits provided within the segments so as to maintain the orientation of such segments during the operation. The weight of the segment as it is lowered is supported by fluid, normally the drilling mud, that fills the hole and the transporter until the segment comes into contact with the top of the uppermost segment on the stack of those segments already placed into the hole. Grout is then placed between the lining segments and the inner wall of the bore hole. The grouting process is periodically carried out after every few segments have been placed into the hole. After the lining operation has been completed, the miners can enter the bore hole for other mining operations.

    摘要翻译： 在从地球开采矿物时，有必要在地球上钻一般在3000和6000英尺之间的深孔。 为了保护进入钻孔的人进行额外的采矿作业，钻孔后，孔内衬有一堆特殊构造的衬里段。 这些段由预应力混凝土或钢制成。 这些段一次一个地下降到钻孔中，以便在孔内形成堆叠，从而衬套孔。 这些片段被运送到运送器上的孔中，然后由运送器下降到孔中。 引导电缆穿过设置在段内的引导管道，以便在操作期间保持这些段的取向。 当下降的段的重量由流体（通常是钻井泥浆）支撑，其填充孔和运输工具，直到段与已经放置在孔中的那些段的堆叠上的最上段的顶部接触 。 然后将灌浆置于衬里段和钻孔的内壁之间。 灌浆过程在每几个细节已经放入孔中之后定期进行。 矿井完成后，矿工可进入钻孔进行其他采矿作业。

    Bore hole mining
    7.
    发明授权
    Bore hole mining 失效
    钻孔采矿

    公开(公告)号：US4330155A

    公开(公告)日：1982-05-18

    申请号：US134296

    申请日：1980-03-26

    申请人： Paul Richardson ,  David A. Whitley

    发明人： Paul Richardson ,  David A. Whitley

    IPC分类号： E21B4/16 ,  E21B7/00 ,  E21B21/00 ,  E21B21/14 ,  E21D1/06

    CPC分类号： E21B21/14 ,  E21B21/00 ,  E21B4/16 ,  E21B7/001

    摘要： Minerals, in particular coal, that have been deposited in layers or along seams in the earth can be mined utilizing a large diameter bore hole drilling equipment. With the drilling equipment stationed on the surface of the earth, a drilling member is drilled down into the earth along the seam of the mineral deposit. If the mineral deposit extends at an angle to the earth, i.e. less than 90.degree., the drilling operation is conducted so as to drill at a similar angle to the earth. As the mineral deposits are broken up during the drilling operation, the broken fragments are removed from the drilled hole. After drilling has occurred for a certain distance in a forward direction, a creeping effect is induced in portions of the side walls of the drilled hole. The drilling member is then retracted from the drilled hole in such a manner so as to drill out any mineral fragments in the hole of the drilling member. These mineral fragments are then removed from the hole as the drilling member is retracted. The removal of the mineral fragments can best be accomplished utilizing an hydraulic flow mechanism for circulating fluid through the drilling member and removing the mineral fragments as they are drilled.

    摘要翻译： 利用大直径钻孔设备可以开采已经沉积在地层中或沿着接缝的矿物，特别是煤。 随着钻井设备驻留在地球表面，沿着矿床的接缝将钻孔构件向下钻入地球。 如果矿床与地球成一定角度，即小于90°，​​则进行钻孔操作以便以与地球相似的角度钻孔。 由于矿物沉积物在钻井操作期间被破碎，破碎的碎片从钻孔中移除。 在向前方向发生一定距离的钻孔之后，在钻孔的侧壁的部分中产生蠕变效应。 然后钻孔构件以这样的方式从钻孔中缩回，以钻出钻孔构件的孔中的任何矿物碎片。 然后当钻孔构件缩回时，这些矿物碎片从孔中移除。 矿物碎片的去除可以利用液压流动机构来完成，该液压流动机构用于使流体通过钻孔构件循环并在钻探时去除矿物碎片。

    SYSTEMS AND METHODS FOR MANAGING MEDICATION-DISPENSING CANISTERS
    8.
    发明申请
    SYSTEMS AND METHODS FOR MANAGING MEDICATION-DISPENSING CANISTERS 有权
    用于管理药物分配器的系统和方法

    公开(公告)号：US20130123977A1

    公开(公告)日：2013-05-16

    申请号：US13298172

    申请日：2011-11-16

    申请人： Ron Sanders ,  Harpreet Singh ,  Frank Mckeown ,  Paul Richardson ,  John M. Manning ,  Darcy O. Clarke

    发明人： Ron Sanders ,  Harpreet Singh ,  Frank Mckeown ,  Paul Richardson ,  John M. Manning ,  Darcy O. Clarke

    IPC分类号： G06F17/00

    CPC分类号： G06F19/3456 ,  A61J7/02 ,  G06F19/00

    摘要： Systems and methods for managing canisters used to automatically dispense medication are provided. Canisters are configurable via a design process and a build process to accurately dispense a variety of medications. Design profiles are created and stored by a canister management system, and are federated to workstations used to build and fill the canisters, and to workstations used to dispense the medication. Information related to the build process, the fill process, and the dispense process is also federated by the system. The system also enables the transmission of other types of messages between client applications on the workstations and the canister management system. The system is useful to federate data regardless of a structure of a supply chain used to design, build, distribute, and use the canisters.

    摘要翻译： 提供了用于管理用于自动分配药物的罐的系统和方法。 罐可以通过设计过程和构建过程进行配置，以准确分配各种药物。 设计简档由罐管理系统创建和存储，并联合到用于构建和填充罐的工作站以及用于分配药物的工作站。 与构建过程，填充过程和分配过程相关的信息也由系统联合。 该系统还能够在工作站和罐管理系统之间的客户端应用程序之间传输其他类型的消息。 该系统对于联合数据是有用的，而不管用于设计，构建，分发和使用罐的供应链的结构如何。

    ORALLY DISINTEGRATING DOSAGE FORMS
    9.
    发明申请
    ORALLY DISINTEGRATING DOSAGE FORMS 审中-公开
    ORALLY DISINCAGE剂量表

    公开(公告)号：US20070292508A1

    公开(公告)日：2007-12-20

    申请号：US11754507

    申请日：2007-05-29

    申请人： Janos Szamosi ,  Liangping Yu ,  Paul Richardson

    发明人： Janos Szamosi ,  Liangping Yu ,  Paul Richardson

    IPC分类号： A61K35/74 ,  A61K31/522 ,  A61K36/18 ,  A61K31/19 ,  A61K31/16 ,  A61K9/26

    CPC分类号： A61K31/16 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/5015 ,  A61K9/5042 ,  A61K31/19 ,  A61K31/522 ,  A61K45/06

    摘要： The present invention is directed to orally disintegrating dosage forms comprising lipid coated substrates and silicified excipients. The use of silicified excipients in the orally disintegrating dosage form along with lipid coating of active agents, allows for improvements in the ability to prepare these dosage forms. Further, the dosage form can prevent unpleasant taste or aftertaste and provide better chemical and mechanical stability of the coated active substrate. This present invention also provides the possibility of harder more durable tablets, along with targeted immediate or modified release profiles for the active agent.

    摘要翻译： 本发明涉及包含脂质包被的底物和硅化赋形剂的口腔崩解剂型。 在口腔崩解剂型中使用硅化赋形剂以及活性剂的脂质涂层，可以提高制备这些剂型的能力。 此外，剂型可以防止令人不愉快的味道或余味，并且提供涂覆的活性底物更好的化学和机械稳定性。 本发明还提供了更坚固的更耐用的片剂以及活性剂的目标立即或修饰释放特征的可能性。

    Blind shaft drilling
    10.
    发明授权
    Blind shaft drilling 失效
    盲轴钻孔

    公开(公告)号：US4516633A

    公开(公告)日：1985-05-14

    申请号：US303511

    申请日：1981-09-18

    申请人： Paul Richardson ,  Daniel C. Albers ,  David A. Whitley

    发明人： Paul Richardson ,  Daniel C. Albers ,  David A. Whitley

    IPC分类号： E21B17/10 ,  E21B21/12 ,  E21B21/14 ,  E21B17/18

    CPC分类号： E21B17/10 ,  E21B21/12 ,  E21B21/14

    摘要： In the mining of various minerals from the earth, large mining shafts extending from the surface down to the deposited mineral layers or seams in the earth can be provided through the use of large diameter bore hole drilling equipment. With the drilling equipment stationed on the surface of the earth, a drilling member is drilled down into the earth for forming a shaft in excess of 10 feet to a depth of at least 2000 feet. As the earth is broken up during the drilling operation, the broken fragments are removed from the drilled hole by a reverse circulation drilling operation. During the drilling operation, the drilling bit is maintained in proper alignment with the shaft being drilled by the use of non-rotating stabilizers having an outer diameter substantially equal to the diameter of the hole being drilled. By maintaining fluid at a sufficient level in the drilled hole during the drilling operation, an adequate hydrostatic head can be created for exerting an opposing pressure on any zone of instability on the walls of the drilled hole for preventing inflow of water and debris.

    摘要翻译： 在从地球开采各种矿物时，可以通过使用大直径钻孔设备来提供从表面向下延伸到沉积的矿物层或接地处的大型矿井。 随着钻探设备驻留在地球表面，钻井部件向下钻进地球，以形成超过10英尺至2000英尺深度的轴。 当钻井操作期间地球被破碎时，通过反循环钻孔操作将破碎的碎片从钻孔中移除。 在钻井操作期间，通过使用具有基本上等于所钻孔的直径的外径的非旋转稳定器，钻头被保持与正在钻孔的轴正确对准。 通过在钻孔操作期间将流体维持在钻孔中的足够的水平面上，可以产生足够的静压头，以在钻孔的壁上的任何不稳定区域上施加相对的压力，以防止水和碎屑流入。